Clinical significance of urinary laminin P1 in diabetic patients

Nakajima, Chiaki; Shimojo, Nobuo; Naka, Keiichi; Okuda, Kiyoshi; Yamamoto, Masaki; Fujii, Satoru

doi:10.1016/0891-6632(91)90073-x

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…As expected, urinary laminin excretion correlates with the urinary excretion of type IV collagen, the main GBM constituent [71]. Because laminin is also found in the tubular basement membrane, it could be expected to find a relationship between urinary excretion of laminin and markers of tubular injury (i.e., NAG, alfa 1 microglobulin, beta 2 microglobulin, and kappa light chains), but conflicting results have been published regarding this correlation [71, 92, 93]. …”

Section: Lamininmentioning

confidence: 82%

“…It is considered that serum laminin cannot be filtered in the normal glomerulus, and the urinary laminin is derived from the kidneys [5]. It has been shown by immunohistochemistry that laminin is located in the mesangial expansion and thickened capillary basement membranes characteristic of diabetic nephropathy [92]. As expected, urinary laminin excretion correlates with the urinary excretion of type IV collagen, the main GBM constituent [71].…”

Section: Lamininmentioning

confidence: 97%

“…However, there are conflicting results regarding the correlation of urinary laminin excretion with UAE [71, 92, 93]. …”

Section: Lamininmentioning

confidence: 99%

“…Urinary laminin excretion increases with age, specifically in patients over 60 years of age [71, 92]. It is significantly correlated with the duration of diabetes [71], blood pressure [71], and glycemic control [71, 93].…”

Section: Lamininmentioning

confidence: 99%

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Urinary Markers of Glomerular Injury in Diabetic Nephropathy

Cohen‐Bucay

Viswanathan

2012

International Journal of Nephrology

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Diabetic nephropathy, the leading cause of renal failure worldwide, affects approximately one-third of all people with diabetes. Microalbuminuria is considered the first sign and the best predictor of progression to renal failure and cardiovascular events. However, albuminuria has several limitations. Therefore, earlier, more sensitive and specific biomarkers with greater predictability are needed. The aim of this paper is to discuss the current literature on biomarkers of glomerular injury that have been implicated in diabetic kidney disease.

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Section: Lamininmentioning

confidence: 82%

Section: Lamininmentioning

confidence: 97%

“…However, there are conflicting results regarding the correlation of urinary laminin excretion with UAE [71, 92, 93]. …”

Section: Lamininmentioning

confidence: 99%

Section: Lamininmentioning

confidence: 99%

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Urinary Markers of Glomerular Injury in Diabetic Nephropathy

Cohen‐Bucay

Viswanathan

2012

International Journal of Nephrology

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“…P1 has mitogenic effects on cells and a number of recent reports have found the P1 fragment to be associated with various pathological conditions that involve basement membrane destruction. For example, serum or urinary P1 fragment has been used as a potential diagnostic and prognostic marker for transitional cell carcinoma of the bladder (Mungan et al, 1996), renal thrombotic microangiopathy (Segarra et al, 2000), and diabetes (Nakajima et al, 1991). The specific function of the P2 fragment has not been extensively characterized.…”

Section: Limited Pepsin Digestionmentioning

confidence: 99%

Proteolytic modification of laminins: Functional consequences

Ghosh

Stack

2000

Microsc. Res. Tech.

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The laminin family contains a number of complex, multi‐domain proteins that participate in a large variety of biologic processes. Limited proteolysis has been utilized extensively as a tool with which to determine laminin structure/function relationships. In addition, proteolytic modification of laminins may occur as a component of heterotrimer assembly and secretion, or may follow incorporation of mature laminin into the extracellular matrix. Conversely, laminin binding to cellular receptors may also influence proteinase expression. This review will highlight specific examples to demonstrate the functional interplay between laminins and proteinases in the regulation of laminin structure and function as well as in the subsequent control of proteinase expression. Microsc. Res. Tech. 51:238–246, 2000. © 2000 Wiley‐Liss, Inc.

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Urinary biomarkers involved in type 2 diabetes: a review

Matheson¹,

Willcox

Flanagan

et al. 2010

Diabetes Metabolism Res

131

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Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be highly beneficial. Urine as a diagnostic medium allows for non-invasive detection of biomarkers, including some associated with type 2 diabetes and its complications. This review provides a synopsis of those urinary biomarkers that potentially may provide a basis for the development of improved diagnostic tests. Three main pathways for the sourcing of potential makers are identified: kidney damage, oxidative stress and low-grade inflammation including atherosclerosis/vascular damage. This review briefly presents each pathway and some of the most relevant urinary biomarkers that may be used to monitor the development or progression of diabetes and its complications. In particular, biomarkers of renal dysfunction such as transferrin, type IV collagen and N-acetyl-beta-D-glucosaminidase might prove to be more sensitive than urinary albumin, the current gold standard, in the detection of incipient nephropathy and risk assessment of cardiovascular disease. Inflammatory markers including orosomucoid, tumour necrosis factor-alpha, transforming growth factor-beta, vascular endothelial growth factor and monocyte chemoattractant protein-1, as well as oxidative stress markers such as 8-hydroxy-2'deoxyguanosine may also be useful biomarkers for diagnosis or monitoring of diabetic complications, particularly kidney disease. However, the sensitivity of these markers compared with albumin requires further investigation.

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Clinical significance of urinary laminin P1 in diabetic patients

Cited by 7 publications

References 5 publications

Urinary Markers of Glomerular Injury in Diabetic Nephropathy

Urinary Markers of Glomerular Injury in Diabetic Nephropathy

Proteolytic modification of laminins: Functional consequences

Urinary biomarkers involved in type 2 diabetes: a review

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