Clinical signs and characteristics of pigmentary glaucoma in Chinese

Qing, Guoping; Wang, Ke

doi:10.1007/s10384-008-0525-y

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…Mid peripheral iris transillumination defect was not present in any of the cases. Because Asians have thicker irises with denser pigmentation than Caucasians [ 7 ], the mid peripheral iris transillumination defect may not be detected unless there is a high degree of pigment dispersion [ 4 ]. In addition, because there are individual differences in the iris thickness and pigmentation even among Asians [ 8 ], the mid peripheral iris transillumination defect will probably be present only if pigment dispersion occurs in eyes with thin and lower density of pigmentation in the iris.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, because there are individual differences in the iris thickness and pigmentation even among Asians [ 8 ], the mid peripheral iris transillumination defect will probably be present only if pigment dispersion occurs in eyes with thin and lower density of pigmentation in the iris. A retrospective study of 21 Chinese patients with PDS or PG reported that all of the patients had pigmentation on the trabecular meshwork and posterior corneal pigmentation (Krukenberg spindle) [ 4 ]. We assumed that these two signs were used for the diagnosis of PDS and PG because mid peripheral iris transillumination defect was found in only one patient.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the individual with angle closure glaucoma is old, hyperopic, and female [ 2 , 3 ]. PG and PDS have been thought to be rare in the Asian population [ 4 ], but it is interesting that the prevalence of myopia is high and is increasing in the younger generation. In addition, the prevalence of NTG is high in Asians and even higher than that in Caucasians [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of pigmentary glaucoma in Japanese individuals

et al. 2022

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Purpose Myopia is a known risk factor of pigmentary glaucoma (PG), and the increased prevalence of myopia in Asian countries indicates that more cases of PG will likely develop soon. However, there are no diagnostic criteria for PG for Asians. Therefore, the purpose of this study is to determine the characteristics of PG in Japanese individuals and establish three diagnostic signs for PG. Methods This was a single-center, retrospective, case series study of glaucoma patients who visited the Kagoshima University Hospital between January 2015 and January 2020. The inclusion criteria were age <50 years at time of diagnosis and presence of pigmentation in the anterior chamber (AC) angle including a Sampaolesi line. Eyes with pigmentation of the AC angle caused by other types of glaucoma such as uveitis, trauma, exfoliation, or childhood glaucoma were excluded. We investigated the classic diagnostic triad of signs of PG; posterior corneal pigmentation, mid peripheral iris transillumination defect, and pigmentation of the trabecular meshwork. We also examined the Sampaolesi line, iris concavity, and midperipheral iris depigmentation in eyes with PG. Results Ten eyes of 5 Japanese men and 10 eyes of 5 Japanese women were studied. Their age ranged from 13 to 46 years at the time of diagnosis. One eye had posterior corneal pigmentation and 6 eyes had pigmentation of the trabecular meshwork. None had mid peripheral iris transillumination defect. The Sampaolesi line, iris concavity, and midperipheral iris depigmentation were found in all patients except one patient who lacked the mid peripheral depigmentation. Two eyes had the pigment reversal sign, none had lens pigmentation, and 2 eyes had peripheral retinal degeneration. Conclusion The presence of the Sampaolesi line, iris concavity, and midperipheral iris depigmentation may be appropriate signs for the diagnosis of PG in Asians.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of pigmentary glaucoma in Japanese individuals

et al. 2022

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“…Twenty one eyes of 11 Chinese (9 males, 2 females) participants in this study identified as PDS and received LPI or trabeculectomy including iridectomy from January to December of 2005 were included in this study. The diagnostic criteria for PDS included at least 2 of the following 3 signs: homogeneous moderate to heavy TM pigmentation (≥Scheie II), lenticular/zonular pigment granule dusting, and corneal endothelial pigmentation in a Krukenberg spindle pattern [3,16,17] . PDS eyes with 2 or more of the following signs were diagnosed with PG: initial IOP > 21mmHg, glaucomatous optic nerve damage (increased cupping or glaucomatous disk appearance), or visual field defect.…”

Section: Methodsmentioning

confidence: 99%

“…The diagnostic criteria for PDS included at least 2 of the following 3 signs: homogeneous moderate to heavy TM pigmentation (≥Scheie II), lenticular/zonular pigment granule dusting, and corneal endothelial pigmentation in a Krukenberg spindle pattern. [3,16,17] PDS eyes with 2 or more of the following signs were diagnosed with PG: initial IOP > 21mmHg, glaucomatous optic nerve damage (increased cupping or glaucomatous disk appearance), or visual field defect. Exclusion criteria included a history of uveitis, trauma, previous ocular surgery or anterior segment laser treatment, or any evidence of exfoliation material.…”

Section: Methodsmentioning

confidence: 99%

Changes of trabecular meshwork pigmentation in patients with pigment dispersion syndrome

Zhou¹,

Tang²,

Pu³

et al. 2021

Medicine

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To report the changes of trabecular meshwork (TM) pigmentation and clinical outcomes of patients with pigment dispersion syndrome (PDS) after resolution of reverse pupillary block.Twenty one eyes of 11 PDS patients were followed up periodically for 15 years after resolution of reverse pupillary block with either Nd: YAG laser peripheral iridotomy (LPI) or trabeculectomy. Visual acuity (VA), best-corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP), Humphrey visual field analysis (VFA), gonioscopy and stereoscopic funduscopy were performed on admission and every 6 months postoperatively. TM pigmentation was quantitatively evaluated and graded every 5 years after the treatment, in which the circumference of anterior chamber angle was divided into 4 quadrants: superior, inferior, nasal and temporal. Postoperative IOP, VA, BCVA, VFA, TM pigmentation and adjunctive anti-glaucoma medications were main outcome measurements and compared with baseline.Eleven patients (9 males, 2 females) were identified as PDS according to the diagnostic criteria, with average age of 38.25 ± 6.93 years (range, 31-55 years) at initial diagnosis. The mean IOP level was 33.1 ± 9.8 mmHg (range, 22-56 mmHg) at diagnosis. Ten PDS eyes received LPI, and the other eleven eyes underwent uneventful trabeculectomy. The median TM pigmentation score of the 21 PDS eyes was 16 (interquartile range [IQR], 15-16) on admission, which changed to 14 (IQR,(13)(14)(15) 13 (IQR,(12)(13)(14) 12(IQR, at 5-, 10-, 15-year follow-up visits respectively. The decrease rate of TM pigmentation was 37% in inferior quadrant, while in nasal, temporal, and superior quadrant the reduction rate was 28%, 23%, and 18%, respectively, at the last follow-up visit. Majority of these enrolled eyes (19/21) had stable VA and BCVA with average endpoint IOP of 15.1 ± 3.4 mmHg.TM pigmentation in PDS patients attenuates with time after reverse pupillary block was resolved, in which the inferior quadrant seems faster than the other quadrants. Abbreviations: AC = anterior chamber, BCVA = best-corrected visual acuity, IOP = intraocular pressure, IPE = iris pigment epithelium, IQR = interquartile range, LPI = laser peripheral iridotomy, PDS = pigment dispersion syndrome, PG = pigmentary glaucoma, TM = trabecular meshwork, VA = visual acuity, VFA = Humphrey visual field analysis.

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