Clinical signs in term infants with different degrees of acidemia in cord blood

Pereira, Denise N.; Procianoy, Renato Soibelmann; Zatti, Helen; Schlabendorff, Mariani

doi:10.2223/jped.296

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…The authors had found low correlation between clinical and laboratories parameters, with pH values to define asphyxia [11]. The same authors, in 1999, in research involving term neonates, also concluded that the Apgar bulletin less than 7 in the fifth minute, associated with the cord blood were not good indicators of evolution of organic failure [12].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Markers of Neonatal Outcomes in Full Term Neonates Suffering from Perinatal Asphyxia

Vargas¹

2015

J Neonatal Biol

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The aim of this study were, using only the score clinic of Sarnat and Sarnat, the blood markers of asphyxia that are routinely used in all hospitals of our country (Brazil) and the ultrasonography imaging method performed with 24 and 72 hours and 28 days of life, verify if these are sufficient to detect the neurological evolution of the patient. Methods The study was conducted with a prospective cohort of term newborns that suffering perinatal asphyxia by Buonocore criteria (2002). These criteria identify the level of the pH in cord blood that was collected of all newborns and also the blood markers: glutamic oxaloacetic transaminase, glutamic pyruvate transaminase, lactate dehydrogenase and creatine kinase (CKMB).These testes were collected at birth, with 24, 48 and 72 hours of life. The score clinical of Sarnat and Sarnat was performed with 24 hours, 48 hours and 72 hours of life and the ultrasound skull with 24, 48, 72 hours of life and in the end of neonatal period with 28 days of life. The period of study was one year. Results In the study´s period 2989 babies were born. The Buonocore criteria were found in 28 newborn showing a frequency of 1% of perinatal asphyxia. The marker of asphyxia were between the normal value of reference and only de iso-enzyme CKMB was a good marker, com value more than 5,10 ng/mL. The brain ultrasonography was altered with 72 hours of life, but one newborn presented alterations only with 28 days of life. The clinical examination using the clinical score of Sarnat and Sarnat demonstrated that 21,42% presented hypoxic-ischemic encephalopathy. In the ROC curve we observed sensitivity of 85,7%, specificity of 85,7% and accuracy of 85,7% correlated the value of CKMB and the brain ultrasonography of 72 hours of life. Conclusions Perinatal asphyxia may be diagnosed in any hospital if the neonatologist or the neurologist apply the easy score clinical of Sarnat and Sarnat, the iso-enzime CKMB and the serial ultrasonography. In this study the worse alteration was with 72 hours of life, however we must be careful because in one neonate the alteration was present only with 28 days of life.

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Section: Discussionmentioning

confidence: 99%

Prognostic Markers of Neonatal Outcomes in Full Term Neonates Suffering from Perinatal Asphyxia

Vargas¹

2015

J Neonatal Biol

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Relationships between cardiovascular signs and neurological signs in asphyxiated neonates in Ilorin, North Central Nigeria

Issa¹,

Abdulkadir²,

Adesiyun³

et al. 2021

Afr H. Sci.

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Background: Perinatal asphyxia is a condition associated with multiple organ dysfunctions inclusive of cardiovascular dys- function. Neurologic predictors of survival have been studied, but little has been reported regarding cardiovascular signs and their role in determining outcome in asphyxia. Objective: The study aimed to determine the relationship between cardiovascular signs and outcomes in asphyxiated new- borns with hypoxic ischaemic encephalopathy. Methods: This was a cross sectional study involving asphyxiated new-born babies recruited within the first 24 hours of life. Hypoxic ischaemic encephalopathy staging was done using Sarnat and Sarnat staging. All patients had a detailed cardi- ovascular examination on admission, after initial resuscitation (30 – 60 minutes) into admission, and were followed till final outcome: discharge or death. Results: Eighty-five asphyxiated new-borns with HIE were studied over seven months. Abnormal cardiovascular-related signs identified in the patients included respiratory distress (64.7%), small volume pulse (57.6%), hypotension (52.9%), hy- poxemia (48.2%) and shock (32.9%). Five babies died. None of the clinical signs had a significant relationship with mortality. Conclusion: Abnormal cardiovascular signs increased with the progression of HIE staging but had no relationship with mortality. Keywords: Cardiovascular signs; Neurological outcomes; Mortality; Perinatal asphyxia.

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Clinical signs in term infants with different degrees of acidemia in cord blood

Cited by 2 publications

References 8 publications

Prognostic Markers of Neonatal Outcomes in Full Term Neonates Suffering from Perinatal Asphyxia

Prognostic Markers of Neonatal Outcomes in Full Term Neonates Suffering from Perinatal Asphyxia

Relationships between cardiovascular signs and neurological signs in asphyxiated neonates in Ilorin, North Central Nigeria

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