Clinical signs, symptoms and serum level of interleukin–6 and tumor necrosis factor in women with or without endometriosis

Hadisaputra, Wachyu

doi:10.1016/s2305-0500(13)60135-9

Cited by 4 publications

(16 citation statements)

References 14 publications

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“…Included dysmenorrhea (during and at the end of menstruation) [ 2 , 7 - 9 , 15 - 17 , 19 - 26 , 28 , 29 , 32 - 37 , 42 , 53 , 54 ], pelvic pain before and during menstruation [ 2 , 7 , 14 , 16 - 18 , 21 , 23 , 25 , 33 , 34 ], and pain during sexual intercourse or after sex (dyspareunia) [ 2 , 7 - 9 , 11 , 15 - 17 , 19 - 25 ]. Dyspareunia was occurred only with deep thrusting [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Lower abdominal pain or suprapubic pain, lower back pain [ 11 , 14 , 17 , 20 , 21 , 29 ] and loin pain [ 17 , 20 ] were also mentioned. Pelvic pain was present as chronic pelvic pain (lasting ≥6 months) and patients reported that they were suffering from intermenstrual pain (non-period pelvic pain) or ovulation pain [ 2 , 7 , 15 , 16 , 19 - 24 , 33 , 34 , 37 , 42 ]. Rectal pain was also mentioned [ 11 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…Included gynecological infections and low resistance to infection, candidiasis [ 11 , 29 , 33 ] infertility [ 2 , 7 - 9 , 16 , 17 , 19 , 21 , 23 - 25 , 29 , 34 , 36 , 37 , 42 , 45 ], pelvic inflammatory disease, ovarian cysts [ 7 , 32 , 33 ] and postcoital bleeding [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

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Clinical diagnosis of pelvic endometriosis: a scoping review

et al. 2015

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BackgroundAccurate and timely diagnosis of endometriosis is associated with confusion. Clinical manifestations, imaging techniques, biomarkers and surgical techniques are used as diagnostic approaches. This paper reviews current evidence on clinical manifestation in order to help practitioners and perhaps improve women’s health.MethodsA review of the literature on clinical diagnosis of pelvic endometriosis that appeared in the English language biomedical journals was performed using PubMed, Science Direct and Google Scholar. The search strategy included the combination of key words ‘endometriosis’ and ‘diagnosis’ or ‘clinical diagnosis’ in the titles or abstracts of articles. The search included all papers published during the year 2000 to 2014. Then, the findings were classified in order to summarize the evidence.ResultsUsing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, in all 51 papers were found relevant and included in this review. In general we found three categories of diagnostic approaches for clinical manifestation including: i) diagnosis via symptoms obtained from history taking, ii) diagnosis via signs obtained from physical examination and iii) diagnosis via risk factors obtained from history taking.ConclusionDiagnosis of endometriosis is a matter of concern. Since the disease is associated with diverse clinical symptoms and signs, deeper and more comprehensive consideration according to patient’s history and clinical findings is recommended for early and more accurate detection in order to prioritize women for further investigation and contribute to its early management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Clinical diagnosis of pelvic endometriosis: a scoping review

et al. 2015

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“…Regarding TNF-α, 78.26% cases of mild (stage II) endometriosis had TNF-α>45.5 pg/ml (cut-off) and 21.74% cases of moderate (stage III) had TNF-α >21.74% which did not show any significant association between stage of endometriosis and cut-off value of cytokines (Table 6). Wachyu [27] was also found that there was no significant difference in mean serum biomarkers level of IL-6, TNF-a, and between endometriosis stage I-II and stage III-IV (1.58 ± 0.78 vs 1.55 ± 0.98 pg/mL, 1.5 ± 0.47 vs 1.49 ± 0.29 pg/ml respectively). Othman et al [29] concluded that level of serum IL-6 was higher in cases of endometriosis but there was no statistical significant difference between subjects with cases of endometriosis and controls.…”

Section: Discussionmentioning

confidence: 86%

“…A study done by Essam et al [26] recruited 68 patients with endometriosis of whom 32 were early stage disease (stage I and II) and 36 advanced stage endometriosis (stage III and IV). Wachyu [27] included 40 patients with endometriosis. Out of which 26 were classified as stage I and II and the remaining were classified as stage III-IV.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Biomarkers as Predictive Indicators of Endometriosis: A Prospective Case Control Study

Journal¹,

Deo²,

Jaiswar³

et al. 2017

IJLSSR

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ABSTRACT-Background:Endometriosis is associated with chronic, benign, oestrogen-dependent inflammatory disease that affects approximately 10% of reproductive age women and 35-50% of women with pelvic pain and infertility. It can be a weakening disease with dysmenorrhoea, dyspareunia, and chronic pelvic pain symptoms. Objective: To evaluate the role of serum marker (IL-6, IL-8, TNF-α) as non-invasive tool to diagnose endometriosis in reproductive age group. Methods: A case control study was conducted in Department of Obstetrics and Gynecology, KGMU, Lucknow for a period of one year. Total numbers of women enrolled in study were 100. Out of 100 women, 75 women of reproductive age group with clinical suspicion and USG findings were taken as cases. Out of 75 cases, 12 cases lost the follow up and 26 cases kept on conservative management and they responded well. Finally 37 cases of endometriosis with strong clinical suspicions (Dysmenorrhea, Heavy or irregular bleeding, Pelvic pain, Lower abdominal or back pain, Dyspareunia, Dyschezia) and USG finding of endometriosis were recruited as cases and they underwent laparoscopy/ laparotomy. Control group comprises of 25 women undergoing for laparoscopic tubal ligation. After taking informed consent, all the women were subjected to the detailed menstrual, gynaecological, medical history and general, systemic and gynaecological examination. Patient was investigated for haemoglobin, ultrasound abdomen and pelvis and serum markers (IL-6, IL-8, TNF-α). Blood sample (5ml of blood) was collected in vecutainer tube for serum analysis. The blood was centrifuged to separate the serum and stored at -70ºC till examined. Finally 37 cases of endometriosis underwent laparotomy/laparoscopy (gold standard to diagnose endometriosis) for proper diagnosis and treatment. Results: Serum IL-8 cut-off at 0.78% pg/ml afforded a sensitivity of 70.3% and specificity of 80% in the diagnosis of endometriosis and has good discriminant ability. TNF-α has average discriminant ability, 62.2% sensitivity and 56% specificity for endometriosis diagnosis. So that serum IL-8 and TNF-α can differentiate cases with or without endometriosis. By detecting these serum markers, we can diagnose endometriosis without undergoing laparoscopy or laparotomy. Conclusion:The serum markers (IL-8, TNF-α) can be used as a non-invasive tool for diagnosis of endometriosis.

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Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

Furucu

Sencar

Çetin

et al. 2020

Cukurova Medical Journal

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Öz Purpose: The aim of this study is to investigate Tumor necrosis factor alpha (TNF-α) and Interleukin 6 (IL-6) expressions in normal and endometriotic human tissue using immunohistochemical methods. Materials and Methods: This study examined tissue sections obtained from the tissue biopsies of ectopic endometrium taken from 24 women between the ages of 20 to 40 years. Additionally, the tissue sections taken from the normal endometrium obtained from 10 patients without any endometrial dysfunction due to dilation or curettage were also evaluated, as the control group. Tissue sections prepared by light microscopic and immunohistochemical methods were examined under a light microscope. Results: In the control group TNF-α and IL-6 expressions were identified at varying levels, from weak to moderate, in surface and glandular epithelium; however, there was no evidence of a significant staining in the stromal cells. It is found that TNF-α and IL-6 immunoreactivity in the endometriotic tissues were significantly increased in the epithelial cells, stromal cells and macrophages compared to the control endometrium. Expressions of TNF-α and IL-6 were both strong in the ectopic endometrial tissues. Conclusion: We conclude that TNF-α and IL-6 are important cytokines involved in the pathogenesis of the endometriosis. Amaç: Bu çalışmada, insanda normal endometriyum ve endometriyotik dokularda Tümör nekroz faktör-α (TNFα) ve Interlökin-6 (IL-6) ekspresyonlarının immünohistokimyasal yöntemler ile araştırılması amaçlandı. Gereç ve Yöntem: Çalışmada incelenen doku kesitleri, 20-40 yaşları arasındaki 24 kadından alınan ektopik endometriyum doku biyopsilerinden elde edildi. Ayrıca herhangi bir endometriyal fonksiyon bozukluğu bulunmayan, ancak diletasyon veya küretaj nedeniyle, 10 hastadan elde edilen endometriyum dokularından alınan kesitler de kontrol grubu olarak değerlendirildi. Işık mikroskobik ve immünohistokimyasal yöntemler ile hazırlanan doku kesitleri, ışık mikroskopta incelendi. Bulgular: TNF-α ve IL-6 ekspresyonunun kontrol grubunda yüzey ve bez epitelinde zayıftan orta dereceye kadar değişen düzeylerde olduğu gözlendi. Buna karşın stromal hücrelerde belirgin bir boyanmaya rastlanmadı. TNF-α ve IL-6'nın endometriyotik dokulardaki immünreaktivitesinin kontrol endometriyum ile karşılaştırıldığında, epitel hücreleri ile stromal hücreler ve makrofajlarda belirgin olarak artış gösterdiği bulundu. TNF-α ve IL-6 ekspresyonlarının her ikisi de ektopik endometriyal dokuda, güçlü olarak eksprese olmuştur. Sonuç: TNF-α ve IL-6'nın endometriyozis oluşumu ve patogenezinde rol alan önemli sitokinler oldukları kanaatine varıldı.

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Clinical signs, symptoms and serum level of interleukin–6 and tumor necrosis factor in women with or without endometriosis

Cited by 4 publications

References 14 publications

Clinical diagnosis of pelvic endometriosis: a scoping review

Clinical diagnosis of pelvic endometriosis: a scoping review

Peripheral Biomarkers as Predictive Indicators of Endometriosis: A Prospective Case Control Study

Expression of interleukin 6 and tumor necrosis factor alpha in endometriotic tissues: an immunohistochemical study

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