Clinical simulators of melanoma

Matz, Hagit; Orion, Edith; Ruocco, Vincenzo; Wolf, Ronni

doi:10.1016/s0738-081x(02)00232-8

Cited by 10 publications

(6 citation statements)

References 129 publications

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“…It is noteworthy that an indistinct “melanoma/sarcoma” syndrome has been described that may represent a genetic constellation of multiple cancers 18, 19. Diagnostic uncertainties in distinguishing between certain forms of melanoma and STS also are possible 20…”

Section: Discussionmentioning

confidence: 99%

The risk of developing second cancers among survivors of childhood soft tissue sarcoma

Cohen

Curtis

Inskip

et al. 2005

Cancer

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BACKGROUND Previous studies have shown that children who are treated for soft tissue sarcoma (STS) are at increased risk for developing second cancers. However, the risk for specific cancer sites and variations in risk by treatment and STS histology remain unclear. METHODS The study evaluated 1499 children (age < 18 years) who survived for ≥ 1 year after they were diagnosed with STS and who were reported to the Surveillance, Epidemiology, and End Results (SEER) population‐based cancer registries from 1973 to 2000. RESULTS Twenty‐seven children developed 28 subsequent primary malignancies, compared with 4.5 expected malignances based on general population rates (observed‐to‐expected [O/E] ratio = 6.3 (95% confidence interval [95% CI], 4.2–9.1). The risk of developing a subsequent malignancy was increased among children with rhabdomyosarcoma (observed = 11 malignancies; O/E ratio = 7.7), fibromatous neoplasms (observed = 9 malignancies; O/E ratio = 5.8), and other specified STS (observed = 7 malignancies; O/E ratio = 6.5). Initial therapy with radiation and chemotherapeutic agents was associated with a significantly higher risk of second malignancies compared with surgery alone (O/E ratio = 15.2 vs. 1.4; P < 0.0001). Elevated risks were observed for acute myeloid leukemia, cutaneous melanoma, female breast cancer, and sarcomas of the bone and soft tissue, with generally higher risks among patients who initially received combined modality therapy. Excess cancers of the oral cavity were prominent among long‐term survivors. For several children, the pattern of multiple malignancies was consistent with a genetic syndrome, particularly neurofibromatosis type 1 and Li–Fraumeni syndrome. CONCLUSIONS The risk of second malignancies was increased for all histologic types of childhood STS and was particularly high among patients who received combined modality therapy. Cancer 2005. Published 2005 by the American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

The risk of developing second cancers among survivors of childhood soft tissue sarcoma

Cohen

Curtis

Inskip

et al. 2005

Cancer

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“…[1][2][3][4][5][6][7][8] Later, Arthur C. Allen (1953) included juvenile melanoma in the category of benign melanocytic lesions due to its benign biological behavior, although it presented a cytoarchitecture that was similar to that of melanoma. [6][7][8][9][10] These two authors classified Spitz nevus as a distinct type of nevus. 6 In 1954, Helwig argued that the term "juvenile melanoma" was inappropriate because it could also occur in adults, not to mention the fact that the term melanoma has a malignant connotation.…”

Section: Historymentioning

confidence: 99%

“…1,6,20 Hypopigmented lesions can be mistaken by amelanotic melanoma and its polypoid variant shows similarities with polypoid melanoma. 6,10 Caucasians seem to be the most affected race, with a higher but discreet incidence in women, perhaps due to the fact that they seek more medical care for cosmetic reasons. 3,5,6,8 The incidence of melanocytic nevi is estimated to vary between 1-10% in childhood.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Spitz nevus and Reed nevus

Yoradjian¹,

Enokihara

Paschoal

2012

An. Bras. Dermatol.

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Spitz and Reed nevi, also called spindle and/or epithelioid cell nevi, are a special group of melanocytic lesions due to their peculiar clinical, dermoscopic and histopathological features. The study of these nevi is of great interest because both their nomenclature and classification are still a matter of discussion. Most importantly, the difficulty to differentiate them from melanoma can lead to inadequate therapies. In this context, dermoscopy, a link between clinical and anatomopathological examinations, appears as a helpful diagnostic tool whose accuracy can reach 93%. "Borderline" lesions are still a great challenge and object of research, including molecular studies. The present study explores the relevant characteristics of these nevi, with emphasis on dermoscopic findings, aiming at understanding their natural history, as well as discussing treatment and patient follow-up. Keywords: Dermoscopy; Melanoma; Nevus, epithelioid and spindle cell Resumo: Os nevos de Spitz e de Reed, ou também chamados nevos de células fusiformes e/ou epitelióides, formam um grupo especial de lesões melanocíticas, por suas características peculiares, tanto clínicas como dermatoscópicas e histopatológicas. Torna-se grande o interesse no estudo desses nevos, pois tanto a nomenclatura como a classificação ainda são motivos de debate e, sobretudo, a dificuldade de diferenciação com o melanoma pode gerar condutas terapêuticas inadequadas. Neste contexto, surge a dermatoscopia, elo entre o exame clínico e o anatomopatológico, como método diagnóstico auxiliar importante cuja acurácia pode chegar a 93%. A grande dificuldade ainda são as lesões "borderline", motivo de pesquisas, incluindo estudos moleculares. O presente estudo aborda os aspectos relevantes das características destes nevos, com ênfase nos achados dermatoscópicos, buscando o entendimento da sua história natural, além da discussão quanto ao tratamento e seguimento dos pacientes. Palavras-chave: Dermoscopia; Melanoma; Nevo de células epitelióides e fusiformes

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“…BN is a congenital and acquired melanocytic proliferation that includes different histological types: common, cellular, atypical cellular, desmoplastic cellular, combined, compound, and malignant [1, 2, 3]. First described by Tièche in 1906 [2, 3], this melanocytic lesion usually appears in childhood and rarely before birth [1, 3].…”

Section: Discussionmentioning

confidence: 99%

Atypical Cellular Blue Nevus of the Foot: A Case Report

Lorenzi¹,

Quenan²,

Ibrahim³

et al. 2019

Dermatopathology

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Blue nevus is a congenital and acquired melanocytic proliferation that includes different histological types. The atypical cellular type has been rarely described and it classically has a benign course. However, because of its intermediate features between common blue nevus and malignant blue nevus, long-term clinical follow-up is required. Here we report the case of a 28-year-old woman who presented with an atypical cellular blue nevus on the right foot.

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Clinical simulators of melanoma

Cited by 10 publications

References 129 publications

The risk of developing second cancers among survivors of childhood soft tissue sarcoma

The risk of developing second cancers among survivors of childhood soft tissue sarcoma

Spitz nevus and Reed nevus

Atypical Cellular Blue Nevus of the Foot: A Case Report

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