Clinical, Social, and Genetic Factors Associated with Obesity at 12 Months of Age

Hazrati, Sahel; Wong, Wendy S. W.; Huddleston, Kathi; Yui, Yvonne; Gilchrist, Nancy; Solomon, Benjamin D.; Niederhuber, John E.; Hourigan, Suchitra K.

doi:10.1016/j.jpeds.2017.12.042

Cited by 7 publications

(6 citation statements)

References 55 publications

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“…Pregnancy details collected from the electronic medical records included the use of prenatal antibiotics (defined as antibiotics given to mother from conception to 2 days prior to delivery) and peripartum antibiotics (defined as antibiotics given to the mother from 2 days prior to delivery to during the delivery). Weight gain during pregnancy was calculated with pre-pregnancy weight and admission weight at delivery, noted in electronic health records [26]. The Health and Medicine Division of the National Academies weight gain recommendations were used to determine whether mothers met the recommended weight gain for their pre-pregnancy body mass index (BMI).…”

Section: Subjects and Sample Collectionmentioning

confidence: 99%

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

et al. 2020

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The meconium microbiome may provide insight into intrauterine and peripartum exposures and the very earliest intestinal pioneering microbes. Prenatal antibiotics have been associated with later obesity in children, which is thought to be driven by microbiome dependent mechanisms. However, there is little data regarding associations of prenatal or peripartum antibiotic exposure, with or without cesarean section (CS), with the features of the meconium microbiome. In this study, 16S ribosomal RNA gene sequencing was performed on bacterial DNA of meconium samples from 105 infants in a birth cohort study. After multivariable adjustment, delivery mode (p = 0.044), prenatal antibiotic use (p = 0.005) and peripartum antibiotic use (p < 0.001) were associated with beta diversity of the infant meconium microbiome. CS (vs. vaginal delivery) and peripartum antibiotics were also associated with greater alpha diversity of the meconium microbiome (Shannon and Simpson, p < 0.05). Meconium from infants born by CS (vs. vaginal delivery) had lower relative abundance of the genus Escherichia (p < 0.001). Prenatal antibiotic use and peripartum antibiotic use (both in the overall analytic sample and when restricting to vaginally delivered infants) were associated with differential abundance of several bacterial taxa in the meconium. Bacterial taxa in the meconium microbiome were also differentially associated with infant excess weight at 12 months of age, however, sample size was limited for this comparison. In conclusion, prenatal and peripartum antibiotic use along with CS delivery were associated with differences in the diversity and composition of the meconium microbiome. Whether or not these differences in the meconium microbiome portend risk for long-term health outcomes warrants further exploration.

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Section: Subjects and Sample Collectionmentioning

confidence: 99%

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

et al. 2020

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“…And it was determined that the first six months of breastfeeding had protective effects on obesity in these children. As a result of the study, breastfeeding and weight gain in pregnancy are affecting childhood obesity as well as genetic factors and they are modifiable factors directly effecting childhood obesity [39].…”

Section: Maternal Nutritional Status During Pregnancy and Breastfeedingmentioning

confidence: 99%

Nutritional factors in etiology of childhood obesity

Çırak¹,

Yilmaz²,

Ayhan³

2018

Gen Med Open

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One of the most important factors in childhood obesity is nutrition. There are a lot of factors that also effect nutrition status and behaviours of children. Factors such as the historical process of food consumption, changes in available foods, inability to manage energy intake, nutritional behaviors of the family, food types that kept at home, maternal nutritional status during pregnancy and breastfeeding are all closely related to obesity in children. In this review, it was aimed to examine the effect of nutritional factors on etiology of childhood obesity. In order to prevent and treat obesity both nutritional status and factors effecting it should be taken into consideration. Childhood obesity is not easy to treat and to improve treatment and success rate, new nutritional approaches should be developed. Dietitians have a major role in nutritional status, nutritional behaviors of children and diagnosis, treatment and monitoring of childhood obesity.

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“…It is encouraging that no Cushingoid features developed, linear growth was maintained, and no laboratory abnormalities were found. However, early onset of excessive weight gain clearly is associated with obesity later in childhood and adult life, and obesity is already a well‐known side effect of GC in DMD. Thus, use of intermittent GC in this age group must involve a “full team” approach including careful nutrition advice and tracking of weight.…”

Section: Discussionmentioning

confidence: 99%

Twice‐weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy

et al. 2019

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Introduction: Glucocorticosteroids (GC) are effective in slowing weakness in boys with Duchenne muscular dystrophy (DMD). Methods: This is a multisite, 1‐year, open‐label trial of twice‐weekly prednisolone (5 mg/kg/dose) in infants/young boys (0.4–2.4 years) with DMD. We compared changes in Bayley III Scales of Infant Development (Bayley‐III) with untreated boys followed for 1 year (historical control cohort [HCC]). Twenty‐three of 25 participants completed the study. Results: Treated boys gained an average of 0.5 points on the Bayley‐III gross motor scaled score (GMSS) compared with the HCC who, on average, declined 1.3 points (P = 0.03). All boys maintained linear growth, and none developed Cushingoid features. Excessive weight gain occurred in 13 of 23 (56%) boys. Discussion: This study provides evidence that twice‐weekly GC is well tolerated in infants and young boys with DMD and improves GMSS. Excessive weight gain is a potential risk. Longer follow‐up is required to determine whether early GC initiation is feasible in most infants/boys with DMD. Muscle Nerve 59:650–657, 2019

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Clinical, Social, and Genetic Factors Associated with Obesity at 12 Months of Age

Cited by 7 publications

References 55 publications

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome

Nutritional factors in etiology of childhood obesity

Twice‐weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy

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