Clinical, sociodemographic and environmental factors impact post-COVID-19 syndrome

Ferreira, Juliana Carvalho; Moreira, Tiana Carla Lopes; Araújo, Adriana Ladeira de; Imamura, Marta; Damiano, Rodolfo Furlan; Garcia, Maria Lúcia Bueno; Sawamura, Marcio VY; Pinna, Fabio; Guedes, Bruno Fukelmann; Gonçalves, Fábio Augusto Rodrigues; Mancini, Márcio C.; Burdmann, Emmanuel A.; Filho, Demóstenes Ferreira da Silva; Polizel, Jefferson Lordello; Bento, Ricardo Ferreira; Rocha, Vanderson; Nitrini, Ricardo; Souza, Heraldo Possolo de; Levin, Anna Sara Shafferman; Kallás, Esper G.; Forlenza, Orestes Vicente; Busatto, Geraldo F.; Batistella, Linamara Rizzo; Carvalho, Carlos Roberto Ribeiro de; Mauad, Thaís

doi:10.7189/jogh.12.05029

Cited by 26 publications

(21 citation statements)

References 42 publications

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“…Viral load is another important parameter to know ( Table 2 ) [ 16 ] for whether people can develop post-COVID-19 symptoms. Our results show that, at a low Ct value [ 15 , 16 , 17 , 18 , 19 , 20 ], patients have between 15 to 20 post-COVID-19 symptoms; likewise, this is reflected when analyzing patients who had an intermediate Ct [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ] who presented between 6 to 11 symptoms, and, finally, there were patients with a low Ct [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] who had few or no symptoms ( Figure 3 A). Therefore, a Pearson correlation was performed between the Ct value and the number of post-COVID-19 symptoms (r = 0.…”

Section: Resultsmentioning

confidence: 96%

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Post-COVID-19 Syndrome in Outpatients and Its Association with Viral Load

Girón-Pérez

Fonseca

Toledo-Ibarra

et al. 2022

IJERPH

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Introduction: The COVID-19 pandemic is the result of the SARS-CoV-2 virus, which has caused more than 100 million infections and more than 2.5 million deaths worldwide, representing a serious public health problem. The gold method for detecting this virus is qRT-PCR, which is a semiquantitative technique where the viral load can be established through its cycle threshold (Ct). It has also been reported that COVID-19 generates long-term symptoms (post-COVID-19). Methods: After three months, a survey was performed on 70 COVID-19 confirmed patients; subsequently, we divided them into four groups (persistent symptoms, chemo-sensitive, cognitive issues, and changes in habit) in order to determine the correlation between viral load and post-COVID-19 symptoms. Results: Data show that fatigue, nervousness, anosmia, and diet changes are common long-term symptoms; in addition, a negative correlation was found between viral load and the number of post-COVID-19 symptoms. Conclusion: COVID-19 generates long-term symptoms which can cause problems with psychological and social repercussions.

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Section: Resultsmentioning

confidence: 96%

“…Since in this region air quality is considered satisfactory, this factor presents a minor or null risk. However, most of the participants mentioned that there was a lot of noise in their places of residence, so this could be a variable to consider as a risk for post-COVID-19 syndrome [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Post-COVID-19 Syndrome in Outpatients and Its Association with Viral Load

Girón-Pérez

Fonseca

Toledo-Ibarra

et al. 2022

IJERPH

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“…A significant proportion of symptomatic patients have reported health issues that persist for weeks, or sometimes months, after the initial COVID-19 infection. This condition, commonly known as “long COVID” or “post-COVID-19 syndrome”, has not been consistently defined, but it appears to be more common in female individuals and in patients with a high body mass index [ 38 ]. However, there is little correlation between the risk of persistent symptoms and objective measures of disease severity.…”

Section: Discussionmentioning

confidence: 99%

The COVID-19 Vaccines International Pregnancy Exposure Registry (C-VIPER): Protocol and Methodological Considerations

Wyszynski¹,

Bhattacharya²,

Martínez-Pérez

et al. 2023

Drug Saf

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Introduction The advent of the coronavirus disease 2019 (COVID-19) pandemic has led to the development of vaccines against severe acute respiratory syndrome coronavirus 2. Prospective evidence regarding safety for pregnant people and their developing fetuses is lacking. The aim of the COVID-19 Vaccines International Pregnancy Exposure Registry (C-VIPER) is to estimate the relative risk of obstetric, neonatal, and infant outcomes by comparing participants vaccinated against COVID-19 during pregnancy to a reference group of people enrolled in the Pregistry International Pregnancy Exposure Registry (PIPER) who remained unvaccinated during pregnancy. Methods The C-VIPER and the PIPER are international, non-interventional, real-world cohort studies. Participants receiving a COVID-19 vaccine during pregnancy will be matched in the analyses by country and gestational age at enrollment to unvaccinated individuals. Self-enrolled and self-consented participants complete online questionnaires at enrollment, during pregnancy, and for 12 months after the delivery of a live infant. Where possible, outcomes are verified by medical records. The study aims to recruit at least 500 pregnancies for each approved or authorized vaccine and will last for 5 years for each product. Conclusions By collecting data for each vaccine brand, the C-VIPER will be able to determine individual safety profiles. The study design allows for analysis of the effects of exposure to COVID-19 vaccines during specific etiologically relevant periods of gestation. Although the sample size may be too small to detect associations with rare outcomes, the study will be used to generate hypotheses for future research. Ultimately, the C-VIPER should provide data that will allow pregnant people and their healthcare providers to make informed decisions about COVID-19 vaccination. Clinical Trial Registration ClinicalTrials.gov NCT04705116. Registered on 12 January, 2021. EU PAS EUPAS39096. Registered on 20 January, 2021.

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“…Surprisingly, qualitative and quantitative muscle changes may persist 3–11 months after hospital discharge and not recover spontaneously, despite the absence of the influencing factors of acute hospitalization. On the other hand, other factors, including physical inactivity exacerbated by quarantine, social distancing measures, poor nutritional status, environmental exposure to air pollution, and poor socioeconomic status may play a role in maintaining the qualitative characteristics in the skeletal muscles of long COVID patients ( 31 ). Also, it is meaningful to consider that the progressive skeletal muscle wasting observed in the first days of ICU stay ( 10 ) has not been managed with specific interventions in our patient population.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic findings in long COVID: A cross-sectional study of 312 patients

Imamura

Uchyiama²,

Naves³

et al. 2023

Front. Med.

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BackgroundFatigue and muscle weakness are common complaints in COVID-19 survivors. However, little is still known about the skeletal muscle qualitative and quantitative characteristics after hospitalization due to moderate and severe COVID-19.ObjectivesTo assess rectus femoris and vastus intermedius muscle thickness (MT) and rectus femoris echo intensity (EI) and to establish its association with demographic, clinical, functional, and inflammatory parameters in long COVID patients after hospital discharge.MethodsCross-sectional study with 312 COVID-19 patients (53.53% male; age: 54.59 ± 13.50 years), with a laboratory-confirmed diagnosis of COVID-19. Patients were assessed 3–11 months after hospital discharge. We evaluated MT of the right rectus femoris and vastus intermedius and EI of the right rectus femoris using a portable ultrasound system, 6–13 MHz, broadband linear transducer. We corrected EI using the subcutaneous fat thickness. Ultrasonographic parameters were tested in association with demographic (sex and age); functional (Handgrip strength measurement, Timed Up and Go, 1 min Sit-to-Stand test, EuroQoL-5 Dimensions-5 Levels, World Health Organization Disability Assessment Schedule (WHODAS 2.0), Post-COVID-19 Functional Status, Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT), Medical Research Council (MRC) sum score, Borg Dyspnea Scale, MRC Dyspnea score, Visual Analogue Scale (VAS), Epworth Sleepiness Scale, Insomnia Severity Index, Functional Independence Measurement (FIM), and Functional Oral Intake Scale); clinical (length of hospital stay, intubation, and presence of comorbidities such as systemic hypertension, diabetes, obesity, chronic obstructive pulmonary disease, asthma), and inflammatory data assessed by the C-reactive protein and D-dimer serum concentrations.ResultsRectus femoris MT was associated with age, handgrip strength, Epworth Sleepiness Scale, and subcutaneous fat thickness (r2 = 27.51%; p < 0.0001). Vastus intermedius MT was associated with age, pain intensity, handgrip strength, Epworth Sleepiness scale, FIM, and time since hospital discharge (r2 = 21.12%; p < 0.0001). Rectus femoris EI was significantly associated with the male sex, TUG, Epworth Sleepiness Scale, and C-Reactive Protein levels (r2 = 44.39%; p < 0.0001). Mean MT of rectus femoris and vastus intermedius are significantly different (p < 0.001).ConclusionAfter hospital discharge, long COVID patients present qualitative and quantitative skeletal muscle characteristics associated with a combination of demographic, clinical, and functional parameters.

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Clinical, sociodemographic and environmental factors impact post-COVID-19 syndrome

Cited by 26 publications

References 42 publications

Post-COVID-19 Syndrome in Outpatients and Its Association with Viral Load

Post-COVID-19 Syndrome in Outpatients and Its Association with Viral Load

The COVID-19 Vaccines International Pregnancy Exposure Registry (C-VIPER): Protocol and Methodological Considerations

Ultrasonographic findings in long COVID: A cross-sectional study of 312 patients

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