Clinical spectrum of acute sporadic hepatitis E and possible benefit of glycyrrhizin therapy

Tandon, Anurag; Bn, Tandon; Ra, Bhujwala

doi:10.1016/s1386-6346(01)00155-3

Cited by 22 publications

(12 citation statements)

References 21 publications

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“…The leaves, roots and rhizomes of licorice have been used traditionally for different purposes including wound healing ( Dafni et al, 1984 ), cough ( Fujita et al, 1995 ) cystitis ( Yarnell, 1997 ), tuberculosis ( Arseculeratne et al, 1985 ), gastric ulcer ( Varshney et al, 1983 ) and diabetes ( Rajurkar and Pardeshi, 1997 ). Licorice shows different pharmacological activities such as hepatoprotective ( Nakamura et al, 1985 ; Lin and Tome, 1988 ; Nose et al, 1994 ; Lin et al, 1999 ; Al-Qarawi et al, 2001 ; Jeong et al, 2002 ; Lee et al, 2009 ; Huo et al, 2011 ), anti-inflammatory ( Finney and Somers, 1958 ; Ohuchi and Tsurufuji, 1982 ; Yu et al, 2015 ; Yang et al, 2016 ), antiviral, antimicrobial ( Shebl et al, 2012 ; Sabouri Ghannad et al, 2014 ; Wang et al, 2015 ) and immunomodulatory effect ( Kimura et al, 1992 ; Tandon et al, 2002 ; Raphael and Kuttan, 2003 ). Glycyrrhizin is widely used for treatment of different types of hepatitis ( Yamamoto et al, 1958 ; Suzuki et al, 1977 ).…”

Section: Glycyrrhiza Glabra Lmentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

et al. 2017

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In many developing countries, jaundice is the common symptom of hepatic diseases which are a major cause of mortality. The use of natural product-based therapies is very popular for such hepatic disorders. A great number of medicinal plants have been utilized for this purpose and some facilitated the discovery of active compounds which helped the development of new synthetic drugs against jaundice. However, more epidemiological studies and clinical trials are required for the practical implementation of the plant pharmacotherapy of jaundice. The focus of this second part of our review is on several of the most prominent plants used against jaundice identified in the analysis performed in the first part of the review viz. Andrographis paniculata (Burm.f.) Nees, Silybum marianum (L.) Gaertn., Terminalia chebula Retz., Glycyrrhiza glabra L. and some species of genus Phyllanthus. Furthermore, we discuss their physiological effects, biologically active ingredients, and the potential mechanisms of action. Some of the most important active ingredients were silybin (also recommended by German commission), phyllanthin and andrographolide, whose action leads to bilirubin reduction and normalization of the levels of relevant serum enzymes indicative for the pathophysiological status of the liver.

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Section: Glycyrrhiza Glabra Lmentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

et al. 2017

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“…Glycyrrhizin is the major active component of the liver therapeutic licorice root, and is a water-soluble molecule and generally used in the clinic for its potent properties in lowering ALT and AST levels in various liver diseases (Van Rossum et al, 1999;Paolini et al, 1999;Tandon et al, 2002.). In our present study, itserved as a control drug and exhibited potency in increasing the activity of antioxidant enzymes of rats in our CCl 4 model experiments.…”

Section: Groupmentioning

confidence: 59%

Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats

Wang

Sun

Zhang

et al. 2008

Journal of Ethnopharmacology

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“…Glycyrrhizin, the aqueous extract of Glycyrrhiza glabra, has received the most attention in the treatment of liver disorders. There are studies demonstrating an improvement in transaminases in patients with viral hepatitis (22)(23)(24) as well as a decrease in the development of cirrhosis and hepatocellular carcinoma in patients with hepatitis C (25) receiving glycyrrhizin. The hepatic antiinflammatory effects of glycyrrhizin may be related to an (26), an inhibition of the lytic pathway of complement (27), and a decrease in production of interleukin-10 by liver dendritic cells (28).…”

Section: Discussionmentioning

confidence: 99%

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis (NASH): A Randomized Pilot Study

et al. 2006

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NASH is a common condition with a rising incidence. There is progression to cirrhosis in some cases and the potential for mortality or requirement of liver transplantation. Currently, there is no approved therapy for NASH. The natural compound YHK has both anti-inflammatory and antifibrotic properties, and can lead to improvement in transaminases in viral hepatitis. Improvement in transaminases may correlate with improved histology in NASH and hence may impact on the natural history. We sought to determine the effects of YHK on NASH. We performed a randomized, double-blind, placebo-controlled pilot study to determine the effects of YHK on transaminases and on quality of life (QoL) in patients with biopsy-confirmed NASH and a persistently abnormal ALT or AST. Eight patients were randomized to YHK or placebo for 8 weeks. The ALT and AST were measured at baseline and weeks 4, 8, and 12. SF-36 surveys were serially completed. All five patients in the YHK group but none in the placebo group had a marked decrease in ALT at both week 4 and week 8 compared to baseline. After discontinuing YHK the ALT returned toward baseline at week 12. The mean decrease in ALT compared to baseline was significantly greater in the YHK group than in the placebo group at both week 4 (-42.8+/-23.2 vs. -6.3+/-6.7 U/L; P=0.036) and week 8 (-45.4+/-23.4 vs. 6.0+/-24.6 U/L; P=0.036). There was also a nonsignificant decrease in AST in the YHK group compared to placebo. QoL was not affected and no severe adverse events were reported. In this controlled pilot study we found the novel nutraceutical agent YHK to be effective at reducing ALT values in patients with NASH. YHK is well tolerated. Further studies are justified to assess the impact of YHK in the natural history of NASH.

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Clinical spectrum of acute sporadic hepatitis E and possible benefit of glycyrrhizin therapy

Cited by 22 publications

References 21 publications

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis (NASH): A Randomized Pilot Study

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