Clinical Spectrum of Adrenal Myelolipoma: Analysis of 8 Tumors in 7 Patients

Sanders, Rodney; Bissada, Nabil K.; Curry, Nancy S.; Gordon, Brian

doi:10.1016/s0022-5347(01)67307-5

Cited by 58 publications

(43 citation statements)

References 4 publications

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“…[42][43][44][45][46] Myelolipomas are often asymptomatic and discovered incidentally in the course of radiologic evaluation of the abdomen. Rarely, they present with symptoms, usually due to large size and/or abdominal pain.…”

Section: Extramedullary Myeloid Proliferations Dp O'malleymentioning

confidence: 99%

“…Rarely, they present with symptoms, usually due to large size and/or abdominal pain. [42][43][44][45][46] A case report found a clonal cytogenetic abnormality in a myelolipoma, suggesting that they may be clonal proliferations. 47 In addition, a recent study by Bishop et al 48 showed 80% of myelolipomas analyzed by X-chromosome inactivation showed nonrandom X-chromosome inactivation in both the marrow elements and fat.…”

Section: Extramedullary Myeloid Proliferations Dp O'malleymentioning

confidence: 99%

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Benign extramedullary myeloid proliferations

2007

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Extramedullary proliferations of bone marrow elements are infrequently encountered in routine pathology practice. On occasion, they can present diagnostic difficulties when seen in unusual or unanticipated sites. This review serves to cover aspects of underlying embryogenesis of myeloid elements, as well as sites and circumstance of benign proliferations of myeloid elements along with their occasional confusion with neoplastic myeloid proliferations. Benign proliferations associated with hematologic disorders and hematopoietic growth factors are discussed. Immunohistochemical evaluation of myeloid proliferations is considered as well. Modern Pathology (2007) 20, 405-415.

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Section: Extramedullary Myeloid Proliferations Dp O'malleymentioning

confidence: 99%

Section: Extramedullary Myeloid Proliferations Dp O'malleymentioning

confidence: 99%

Benign extramedullary myeloid proliferations

2007

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“…TERATOMA (CASES [15][16][17] Three patients (two women, one man) with teratomas were noted. They presented with non-specific back pain and adrenal masses were detected on imaging.…”

Section: Resultsmentioning

confidence: 99%

Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution

Lam¹,

Lo²

2001

Journal of Clinical Pathology

153

134

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1 However, the importance of asymptomatic adrenal masses discovered incidentally during the investigation of unrelated problems was stressed by Geelhoed and Druy in 1982. 2 With the increased availability of high resolution ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI), incidental adrenal lesions are increasingly reported. This leads to dilemmas in the evaluation and management of these lesions. Adrenal tumours of uncommon pathology were more frequently reported.Myelolipoma is included as one of the diVerential diagnoses for incidental adrenal lesions. 4 Other lipomatous lesions were rarely described in the English literature. [5][6][7][8][9][10] In our study, we reviewed the clinicopathological features of adrenal lipomatous tumours encountered in our hospital. Most were discovered as incidental adrenal lesions. In addition, rare pathology not previously documented in the adrenal gland will be described. MethodsThe histological reports of primary adrenal tumours between 1 January 1970 and 31 December 1999 were retrieved. Tumours with adipose tissue as the sole or one of the major components were selected for review. In each case, the clinical presentation, location of the tumour, and the outcome for the patient were studied. Details of the pathological examination, including the gross appearance and size of the tumours, were noted. Immunohistochemical studies (using antibodies against muscle specific actin, desmin, HMB45, etc) were undertaken when necessary to confirm the diagnoses. Flow cytometry for ploidy analysis was used to analyse tumours with atypical histological features by adopting the previously described methodology. 11 ResultsTwenty patients (12 men, eight women) with adrenal lipomatous tumours were noted (table 1). Ten tumours each were obtained from surgical biopsy and postmortem files. The tumours comprised myelolipoma, lipoma, teratoma, angiomyolipoma, and liposarcoma. Some of these cases have been reported previously.10 12 13 Over the 30 year study period, 418 primary adrenal tumours were recorded in the pathology file. Of these, 238 were from the surgical biopsy files and 180 from the postmortem files (from a total of 13 732 necropsies). Thus, adrenal lipomatous tumours comprised 4.8% (20 of 418) of primary adrenal tumours. These tumours accounted for 4.2% (10 of 238) of the surgically resected and 5.6% (10 of 180) of necropsy detected primary adrenal tumours detected. The prevalence of adrenal lipomatous tumours was 0.07% at necropsy. MYELOLIPOMAS (CASES 1 TO 11) Eleven adrenal myelolipomas were found and they accounted for 2.6% of the primary adrenal tumours. Eight tumours were detected during necropsy, giving a postmortem prevalence of 0.06%, whereas three resected myelolipomas accounted for 1.3% of the surgically resected primary adrenal tumours. These three patients presented with adrenal "incidentalomas" on cross sectional imagings. They were free of disease 12 years, 4.5 years, and 0.5 years after excision of the adrenal tumours.There were eight men a...

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“…yaptığı cerrahi olarak çıkarılmış 70 vakayı kapsayan bir çalışmada, olguların 36 tanesinde klinik olarak karın ağrısı veya ele gelen kitle tespit edilmiştir. Eşlik eden hastalıklar incelendiğinde bu hastaların 17'sinin obez, 18'inin hipertansif ve 18'inin de çeşitli kronik sistemik hastalıkları olduğu görülmüştür [5]. Etyolojisini aydınlatmak için çeşitli teoriler ortaya atılmıştır.…”

Section: Discussionunclassified

Unusual Giant Adrenal Myelolipoma with Chronic Mild Postprandial Pain

Söylemez¹

2015

Ann Clin Anal Med

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ÖzetAdrenal miyelolipomlar, lipom ve liposarkom gibi diğer adrenal tümörlerden histopatolojik olarak farklılık gösteren nadir, küçük, benign, nonfonksiyonel tümörlerdir. Çoğunlukla rastlantısal olarak otopsi, radyolojik tetkikler veya laparotomi sırasın-da tanı alırlar. Bazen, retroperitoneal kanama, sistemik semptomlar veya enfeksiyon gibi nedenlerle akut semptomlarla ortaya çıkabilirler. Ayırıcı tanıda Manyetik Rezonans Görüntüleme, doku orjinini ve çevre organ ilişkilerini göstermesi nedeniyle faydalıdır. Biz bu yazıda, klinik olarak yemek sonrası kronik karın ağrısı ile ortaya çıkan dev boyutlu bir adrenal miyelolipomlu altmış altı yaşında erkek hastayı kısa bir literature bilgisi eşliğinde sunmayı amaçladık. Anahtar KelimelerAdrenal; Miyelolipom; Tümör Abstract Adrenal myelolipomas are rare, small, benign, non-functioning tumors, which must be histopathologically differentiated from other tumors such as lipomas or liposarcomas. They are usually identified incidentally during autopsy, imaging or laparotomy. Occasionally, they may present acutely due to complications such as abdominal pain from retroperitoneal bleeding or systemic symptoms of infection. In differantial diagnosis, Magnetic Resonance Imaging may be useful to show characterize of tissue and relationship with other organs. We report a 66-yearold man with a giant adrenal myelolipoma clinically presenting with chronic mild postprandial pain with a brief review of the literature.

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Clinical Spectrum of Adrenal Myelolipoma: Analysis of 8 Tumors in 7 Patients

Cited by 58 publications

References 4 publications

Benign extramedullary myeloid proliferations

Benign extramedullary myeloid proliferations

Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution

Unusual Giant Adrenal Myelolipoma with Chronic Mild Postprandial Pain

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