Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children

Tagarro, Alfredo; Cobos‐Carrascosa, Elena; Villaverde, Serena; Sanz-Santaeufemia, Francisco-Javier; Grasa, Carlos; Soriano‐Arandes, Antoni; Hernanz, Alicia; Navarro, Marı́a Luisa; Pino, Rosa; Epalza, Cristina; Batista, Rosa; Rizo, Jana; Iglesias-Bouzas, María Isabel; Rodríguez-Molino, Paula; Villanueva-Medina, Sara; Carrasco-Colom, Jaime; Alonso-Cadenas, J A; Mellado, María-José; Herrero, Blanca; Melendo, Susana; Torre, Mercedes de la; Calleja, Lourdes; Calvo, Cristina; Urretavizcaya-Martinez, María; Astigarraga, Itziar; Menasalvas, Ana; Penin, María; Neth, Olaf; Berzosa, Arantxa; Ceano-Vivas, María de; Vidal, Paula; Belinchón, Isabel; Gonzalez, Raul Calvo; García, María Luz; Mesa, J. A. D.; Ballesteros, Álvaro; Bernardino, Maria de Lourdes Amaral; Moraleda, Cinta

doi:10.1007/s00431-021-04306-6

Cited by 30 publications

(25 citation statements)

References 20 publications

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“…We compared the features of the 109 ambulatory children attended during the Omicron wave in these 2 centers to 546 ambulatory children attended in previous waves in 35 centers, from March 2020 to October 2021, included in the national COVID-19 EPICO-AEP registry (Table 1 ). 2 During the Omicron wave, more children presented upper respiratory tract infection, but fewer children had pneumonia. Fever, headache, and diarrhea were more common during the Omicron wave.…”

Section: To the Editorsmentioning

confidence: 99%

Features of COVID-19 in Children During the Omicron Wave Compared With Previous Waves in Madrid, Spain

Tagarro

Coya

Pérez-Villena

et al. 2022

Pediatric Infectious Disease Journal

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Section: To the Editorsmentioning

confidence: 99%

Features of COVID-19 in Children During the Omicron Wave Compared With Previous Waves in Madrid, Spain

Tagarro

Coya

Pérez-Villena

et al. 2022

Pediatric Infectious Disease Journal

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“…These are mainly pneumonia, but can also include multisystem inflammatory syndrome in children (MIS‐C). Many of these children need to be admitted to a paediatric intensive care unit (PICU) 3 …”

Section: Introductionmentioning

confidence: 99%

“…Many of these children need to be admitted to a paediatric intensive care unit (PICU). 3 Prolonged symptoms following the acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may last longer than 4 or even 12 weeks and have been widely described in both adult 4 and paediatric populations. [5][6][7] The UK National Institute for Health and Care Excellence (NICE) published guidelines in December 2020 on long COVID.…”

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confidence: 99%

Comparative study shows that 1 in 7 Spanish children with COVID‐19 symptoms were still experiencing issues after 12 weeks

et al. 2022

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Aim We investigated prolonged symptoms in children after COVID‐19, including the clinical characteristics and risk factors. Methods This multicentre retrospective study focused on 451 children under 18 years old who were diagnosed with symptomatic COVID‐19 between 14 March and 31 December 2020. Persistent symptoms were analysed with a telephone questionnaire by the attending physicians from 1 August to 30 September 2021. A control group of 98 with no history of COVID‐19, who were treated for other reasons, was also included. Results Most (82.0%) of the cases had mild infections that required outpatient care and 5.1% were admitted to the paediatric intensive care unit (PICU). We found that 18.4% had symptoms that lasted 4–12 weeks. There were also 14.6% who were symptomatic for longer than 12 weeks and the odds risks were higher for children aged 5 years or more (OR 3.0), hospitalised (OR 3.9), admitted to the PICU (OR 4.3) and with relatives who were symptomatic for 12 weeks or more (OR 2.8). The controls had similar percentages of prolonged symptoms, despite having no history of COVID‐19, especially those who were older than 5 years. Conclusion This study confirmed that a worrying percentage of children had prolonged symptoms after COVID‐19.

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“…Despite this, some children can develop multi-system inflammatory syndrome in children (MIS-C), a rare but severe and life-threatening complication, similar to Kawasaki disease and probably result from a hyper-inflammatory state that usually occurs weeks after the infection [ 18 – 21 ]. Most MIS-C patients require hospitalization and pediatric intensive care unit (PICU) admission [ 20 – 24 ], and a significant proportion of them present with neurologic manifestations [ 19 , 21 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and neurologic manifestations: a synthesis from the child neurologist’s corner

Valderas¹,

Méndez²,

Echeverría³

et al. 2022

World J Pediatr

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Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children

Cited by 30 publications

References 20 publications

Features of COVID-19 in Children During the Omicron Wave Compared With Previous Waves in Madrid, Spain

Features of COVID-19 in Children During the Omicron Wave Compared With Previous Waves in Madrid, Spain

Comparative study shows that 1 in 7 Spanish children with COVID‐19 symptoms were still experiencing issues after 12 weeks

COVID-19 and neurologic manifestations: a synthesis from the child neurologist’s corner

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