Clinical Spectrum of Reversible Posterior Leukoencephalopathy Syndrome

Lee, Vivien; Wijdicks, Eelco F. M.; Manno, Edward M.; Rabinstein, Alejandro A.

doi:10.1001/archneurol.2007.46

Cited by 545 publications

(710 citation statements)

References 21 publications

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“…1A- (Fig. 1F, G) g e s o b t a i n e d a t d a y -1 0 ( A) a n d d a y -2 0 ( B ) r e s p e c t i v e l y . of the lesions are regarded as 'atypical' in this syndrome (10,11) (14). Cerebrovascular autoregulatory dysfunction is considered as the dominant underlying mechanism of these lesions.…”

Section: Thrombotic Thrombocytopenic Purpura (Ttp) Is An Autoimmune Dmentioning

confidence: 99%

Atypical Reversible Posterior Leukoencephalopathy Syndrome in Thrombotic Thrombocytopenic Purpura

2008

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Section: Thrombotic Thrombocytopenic Purpura (Ttp) Is An Autoimmune Dmentioning

confidence: 99%

Atypical Reversible Posterior Leukoencephalopathy Syndrome in Thrombotic Thrombocytopenic Purpura

2008

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“…Posterior reversible encephalopathy syndrome (PRES) is a clinico‐radiological syndrome (Lee, Wijdicks, Manno, & Rabinstein, 2008). Clinical symptoms are headache, visual disturbance, mental alteration, and seizure.…”

Section: Introductionmentioning

confidence: 99%

The effect of presymptomatic hypertension in posterior reversible encephalopathy syndrome

et al. 2018

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ObjectiveThe effect of blood pressure (BP) on the lesion distribution of posterior reversible encephalopathy syndrome (PRES) is controversial. The aim of this study was to identify the relationship between brain lesion distribution patterns and BP.MethodsSixty‐five patients with PRES were selected from the database. Data regarding brain MRI findings, clinical symptoms, medical conditions, and BP at the presymptomatic period (24 hr before the symptom onset) and at the symptom onset were collected. The brain lesion distribution degree was numerically calculated (lesion scoring point [LSP]) and compared with BP and medical conditions.ResultsMean onset‐MAP was higher than mean pre‐MAP. Pre‐MAP correlated with onset‐MAP. The LSP was significantly correlated with pre‐MAP (p = 0.009, correlation coefficient [cc] = 0.323), whereas no significant correlation was found between LSP and onset‐MAP (p = 0.159, cc = 0.177). Similarly, when patients were grouped by mean MAP values, LSP was significantly higher in the patients with high MAP at the presymptomatic period (p = 0.004), whereas no difference was found in the LSP value between patients with low MAP and high MAP at the symptom onset (p = 0.272).ConclusionThe patient with PRES who has relatively higher BP in the presymptomatic period would be more likely to have wider lesion distribution than the patient with lower BP. BP elevation during presymptomatic period may be a heralding sign of impending PRES and a factor affecting the severity of PRES although BP was not investigated at earlier time points.

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“…Recurrent episodes of PRES may also occur, but are rare. Unilateral involvement and hemorrhage in the lesions is seen in 5% of patients, and permanent changes in the form of small lesions occurred in 26% in one large series 7. Clinical features include seizures (87%), encephalopathy (92%), visual symptoms (39%), and headache (53%) 7…”

Section: Discussionmentioning

confidence: 99%

Involvement of the cervical cord and medulla in posterior reversible encephalopathy syndrome

Choh

Jehangir

Rasheed

et al. 2011

Annals of Saudi Medicine

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The posterior reversible encephalopathy syndrome (PRES) is characterized by patchy cortical and subcortical lesions in the distribution of the posterior circulation. The lesions are classically reversible. This syndrome has multiple etiologies, most of which cause acute hypertension. We present a case of PRES with involvement of the medulla and cervical cord (apart from the typical parieto-occipital lesions)-an extremely rare imaging manifestation of PRES. It is important to recognize the imaging findings of PRES in spinal cord, and avoid misdiagnosis as myelitis by proper clinical correlation. Typically patients with myelitis have a profound neurodeficit, while patients with spinal manifestations of PRES are asymptomatic. Involvement of the cord in PRES has probably been an underrecognized entity as spinal imaging is not routinely performed in posterior reversible encephalopathy syndrome.

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Clinical Spectrum of Reversible Posterior Leukoencephalopathy Syndrome

Cited by 545 publications

References 21 publications

Atypical Reversible Posterior Leukoencephalopathy Syndrome in Thrombotic Thrombocytopenic Purpura

Atypical Reversible Posterior Leukoencephalopathy Syndrome in Thrombotic Thrombocytopenic Purpura

The effect of presymptomatic hypertension in posterior reversible encephalopathy syndrome

Involvement of the cervical cord and medulla in posterior reversible encephalopathy syndrome

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