Clinical staging of feline immunodeficiency virus infection.

Ishida, Takuo; Tomoda, Isamu

doi:10.1292/jvms1939.52.645

Cited by 83 publications

(65 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ARC and AIDS phases have defective blastogenesis to T eeil mitogens [4,[8][9][10][11]. blastogenesis to Con A and PWM was not impaired in cats in acute phase FIV infection, in this study.…”

Section: Discussionsupporting

confidence: 46%

“…It has been possible to stage FIV infection into distinct stages comparable to those in HIV-I Infeetion [4]. Experimental infeetion of cats is followed by an acute phase which lasts several weeks to months.…”

Section: Introductionmentioning

confidence: 99%

“…Avon BS18 7DU, UK. function through the clinical phases of FIV infeetion [4], sueh as reduced numbers of eirculating Ct>4^ T cells, inverted CD4+/ CD8 * ratios, and depressed lymphoeyte function, as measured by mitogen blastogenesis [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An early defect in primary and secondary T cell responses in asymptomatic cats during acute feline immunodeficiency virus (FIV) infection

Bishop

Williams

Gruffydd-Jones

et al. 1992

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYAs in HIV infection of humans, cats infected with FIV are particularly susceptible to secondary infection by opportunistic pathogens, suggesting an impaired ability to elicit an effective immune response against foreign antigens. In order to investigate the development of immunity in FIVinfected cats, we have used an autologous culture system to directly measure priming of naive CD4+ T eells to soluble protein antigen, in vitro. Using this assay, we showed previously that cats infeeted with FIV for several months had significantly reduced primary proliferative responses. We have now examined cats before infection, and at varying times after infection with FIV, to determine how soon after infeetion this defect in T eell priming was evident, compared with other quantitative and qualitative measurements of lymphocyte function. Our results showed a progressive decline in immune function in asymptomatic cats during the acute stage of infection with FIV. Primary T cell responses were most sensitive and a significant reduction in proliferation of naive T cells to foreign antigen occurred 5 weeks after infeetion, despite normal blastogenesis to T cell mitogens and normal CD4' /CDS * ratios at these times. Whilst lymphoeyte proliferation to T cell mitogens was unaffected throughout, a significant reduction in proliferation to a B cell mitogen occurred from week 8 onwards. CD4*/CD8' ratios fell signifieantly from week 13 onwards, and proliferation ofthe memory Tcell population to a recall antigen was significantly impaired later, from week 19 onwards. The defect in the priming of naive T cells to foreign antigen early after infection may be important in determining susceptibility to secondary infections.

show abstract

“…ARC and AIDS phases have defective blastogenesis to T eeil mitogens [4,[8][9][10][11]. blastogenesis to Con A and PWM was not impaired in cats in acute phase FIV infection, in this study.…”

Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An early defect in primary and secondary T cell responses in asymptomatic cats during acute feline immunodeficiency virus (FIV) infection

Bishop

Williams

Gruffydd-Jones

et al. 1992

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…The virus is a lentivirus capable of producing an acquired immunodeficiency syndrome (AIDS) in domestic cats with biologic characteristics similar to human immunodeficiency virus (HIV) [15,16,20,21,37,45]. The FIV-cat system is considered to be an attractive animal model for HIV infection [33], because of the pathogenic similarities between the two viruses including the disease course and the presence of T-cell immunodeficiency.…”

Section: Virusmentioning

confidence: 99%

“…The clinical course of FIV infection is classified into five stages according to clinical symptoms; the acute phase (AP), the asymptomatic carrier (AC), persistent generalized lymphadenopathy (PGL), AIDS-related complex (ARC) and AIDS [16,33]. Though the clinical staging may be helpful in establishing an approximation of the disease stages and prognosis, more accurate means of evaluating the infected cats are often required, to which extent immunologic evaluation involving the peripheral blood T-cell subpopulations has been carried out in some experimental settings [1,2,4,8,27,42,44].…”

Section: Virusmentioning

confidence: 99%

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Alterations of T-cell subsets in the lymph nodes from FIV-infected cats in various clinical disease stages were examined histologically. In the early stage of infection (AP stage), follicular hyperplasia accompanied by expansion of the paracortical area was observed. Follicular involution and depletion with reduced paracortical area was observed in the ARC and AIDS stage nodes. The maximum section area of the entire popliteal lymph node was expanded significantly in the AP nodes. The paracortical area expanded in the AP nodes and decreased in the ARC and AIDS stage nodes. The cell density in the paracortical area in the AP nodes did not show a significant increase, while there was a significant reduction in the ARC and AIDS stage nodes. The lymph node CD4/CD8 ratio in the AP and ARC stages significantly decreased as compared with that of uninfected control cats, but conversion of the ratio was not seen. The estimated total numbers of CD4 + and CD8 + cells in the maximum section were increased in the AP stage but significantly decreased in the ARC and AIDS stages. Our study indicated that the lymphocyte depletion in the terminal ARC and AIDS stages of FIV infection was associated with both CD4 + cells and CD8 + cells. Findings obtained in this study might provide useful information for studying the pathophysiology of FIV infection. -KEY WORDS: CD4, CD8, feline immunodeficiency virus, lymph node.

show abstract

Animal Models of Retroviral Encephalopathies: Feline Model

et al. 2001

View full text Add to dashboard Cite

Human immunodeficiency virus infection in children and adults results in a progressive neurodegenerative disease consistent with a predominant subcortical mediated dementia. Techniques for developing a feline model of the early stages of lentiviral-associated neurodegeneration are presented. The behavioral, neurophysiologic, immunologic, virologic, and neuropathologic aspects of this model are also described.

show abstract

Clinical staging of feline immunodeficiency virus infection.

Cited by 83 publications

References 0 publications

An early defect in primary and secondary T cell responses in asymptomatic cats during acute feline immunodeficiency virus (FIV) infection

An early defect in primary and secondary T cell responses in asymptomatic cats during acute feline immunodeficiency virus (FIV) infection

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Animal Models of Retroviral Encephalopathies: Feline Model

Contact Info

Product

Resources

About