Clinical Status and B-Type Natriuretic Peptide Levels in Patients with Heart Failure at Hospital Discharge

Oral, I; Mistrík, Jerguš; Náplava, Robert

doi:10.1007/s00059-007-2903-5

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Initial signals from retrospective analyses [20,21] are encouraging, but clear guidance for clinical practice is still missing. Available evidence is suggestive for the potential of natriuretic peptides in this regard, but robust evidence is still lacking.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Biomarkers for Chronic Heart Failure

Lainščak

Anker

Haehling

et al. 2009

Herz

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Cardiac biomarkers are very important in diagnosis, risk stratification, and management of patients with heart failure. Although not meeting all criteria for an ideal biomarker, natriuretic peptides primarily have a diagnostic and prognostic role. Other routinely available and newly emerging biomarkers have a complementary role in patient management; thus multimarker strategy might be warranted in future. The quest for a single marker or a combination is ongoing and several established, widely available biomarkers might have been overlooked in the field of heart failure. The authors review some of those biomarkers and speculate on the possible roles of combining two or more of them.

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Section: Natriuretic Peptidesmentioning

confidence: 99%

Biomarkers for Chronic Heart Failure

Lainščak

Anker

Haehling

et al. 2009

Herz

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“…Positive signals come from retrospective analyses, but a clear guidance for clinical practice is still lacking [10]. Both are associated with decision-making and can modify the hospital discharge priority or tailor therapeutic modalities to patients.…”

Section: Laboratory Biomarkersmentioning

confidence: 99%

Prognostische Faktoren bei chronischer Herzinsuffizienz. Eine Übersicht zu Biomarkern, metabolischen Faktoren, Symptomatik und Score-Systemen

Lainščak

Anker

2009

Herz

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Decision-making in the care for patients with chronic heart failure (CHF) has become increasingly difficult. The many available therapeutic strategies and novel treatment modalities with borderline or modest benefit call for careful risk stratification in patients with CHF. Rather than relying on highly sophisticated and expensive procedures, we may find routinely available parameters of clinical value. This review considers the importance and validity of serum biomarkers (like natriuretic peptides, uric acid, lipoproteins, and cytokines), metabolic changes (like insulin resistance or body mass index), patient measures of symptom status and exercise capacity, as well as prognostic scoring systems. There is limited evidence that the use of prognostic markers to make treatment decisions improves the outcome in CHF. Many studies still need to be done to this end.

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Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate

Heuvel

Curti

Vanoni

et al. 2004

Cellular and Molecular Life Sciences (CMLS)

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Glutamate synthase is a multicomponent iron-sulfur flavoprotein belonging to the class of N-terminal nucleophile amidotransferases. It catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate. In recent years the X-ray structures of the ferredoxin-dependent glutamate synthase and of the a subunit of the NADPH-dependent glutamate synthase have become available. Thanks to X-ray crystallography, it is now known that the ammonia reaction intermediate is transferred via an intramolecular tunnel from the amidotransferase domain to the synthase domain over a distance of about 32A. Although ammonia channeling is a recurrent theme for N-terminal nucleophile and triad-type amidotransferases, the molecular mechanisms of ammonia transfer and its control are different for each known amidotransferase. This review focuses on the intriguing mechanism of action and self-regulation of glutamate synthase with a special focus on the structural data.

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Clinical Status and B-Type Natriuretic Peptide Levels in Patients with Heart Failure at Hospital Discharge

Cited by 5 publications

References 26 publications

Biomarkers for Chronic Heart Failure

Biomarkers for Chronic Heart Failure

Prognostische Faktoren bei chronischer Herzinsuffizienz. Eine Übersicht zu Biomarkern, metabolischen Faktoren, Symptomatik und Score-Systemen

Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate

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