Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry

Bokemeyer, Bernd; Hardt, Judith Nora; Hüppe, D; Prenzler, Anne; Conrad, Stefan; Düffelmeyer, M.; Hartmann, Petra; Hoffstadt, M; Klugmann, Tobias; Schmidt, Carsten; Weismüller, Josef; Mittendorf, Thomas; Raspe, Heiner

doi:10.1016/j.crohns.2012.02.014

Cited by 90 publications

(67 citation statements)

References 27 publications

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“…Especially, relapses are associated with high health care costs and a decreased quality of life. [1][2][3] Up to 10% of IBD flares are reported to be the result of microbial pathogen invasion. 4 In the last decade, several studies have focused on the possible association between Clostridium difficile and IBD.…”

mentioning

confidence: 99%

Is Clostridium difficile Associated With Relapse of Inflammatory Bowel Disease? Results From a Retrospective and Prospective Cohort Study in the Netherlands

Masclee

Penders

Jonkers

et al. 2013

Inflammatory Bowel Diseases

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confidence: 99%

Is Clostridium difficile Associated With Relapse of Inflammatory Bowel Disease? Results From a Retrospective and Prospective Cohort Study in the Netherlands

Masclee

Penders

Jonkers

et al. 2013

Inflammatory Bowel Diseases

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“…5 Worryingly, nowadays this remains an issue, since a significant proportion of patients report lack of intimate relationships due to IBD and sexual problems seem to be common [20.6%]. 2,6 Despite the apparent impact of the impaired sexual function, the number of relevant studies is limited. Therefore, the aim of this study was to present the available data over the past 10 years concerning the evaluation of sexual function among males and females with IBD.…”

mentioning

confidence: 99%

“…2,3,4 Almost 40 years ago Gazzard et al reported a decreased sexual activity among patients with IBD. 5 Worryingly, nowadays this remains an issue, since a significant proportion of patients report lack of intimate relationships due to IBD and sexual problems seem to be common [20.6%].…”

mentioning

confidence: 99%

Inflammatory Bowel Disease and Sexual Function in Male and Female Patients: An Update on Evidence in the Past Ten Years

Mantzouranis

Fafliora

Glanztounis

et al. 2015

ECCOJC

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Background and Aims: Inflammatory bowel diseases [IBD] are a group of chronic, debilitating inflammatory intestinal conditions. The aim of this review was to assess the recent data regarding the impact of IBD in sexual function of male and female patients. Methods: A literature search was conducted on MEDLINE using, among others, the following search terms or their combinations: ulcerative colitis; Crohn's disease; sexual function; sexual health; relationship status; erectile dysfunction; surgery. All English-language studies published in the past 10 years which provided data evaluating the sexual function in IBD patients were included. Results: Fourteen studies were identified; six included IBD patients registered on a national database or presented in a clinical setting, whereas eight evaluated sexual function after a surgical intervention for IBD. The majority of the studies used the validated for general populations International Index for Erectile Function [IIEF] and the Female Sexual Function Index [FSFI] for the assessment of sexual function among males and females, respectively. An impaired sexual function has been reported in general cohorts of IBD patients; females seemed to experience worse sexual dysfunction than males. Furthermore, depression was a consistent negative predictive factor across studies. Surgery did not seem to affect sexual function in the majority of studies, except a prospective one which reported a significant improvement in male sexual function [IIEF, p < 0.05] but not female [FSFI, p = 0.6]. Conclusions: Sexual function among IBD patients may be impaired, thus more studies are needed in order to develop the appropriate instruments and proper and effective management strategies.

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“…Several studies have concluded that anxiety and depression are common in IBD patients, and their severity parallels the disease activity [167][168][169][170]. These psychological conditions may not simply be the consequences of the chronic illness.…”

Section: Stress and Mood Disordersmentioning

confidence: 99%

Pathogenesis of Ulcerative Colitis and Crohn’s Disease: Similarities, Differences and a Lot of Things We Do Not Know Yet

Molnár¹

2014

J Clin Cell Immunol

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The pathogenesis of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD) is complex, and our knowledge on the topic is constantly growing. The two disorders are distinct, yet overlap in their clinical manifestations and underlying causes. This review aims to provide a broad overview of the numerous pathogenetic factors that can lead to the development of IBD, focusing on novel findings and on the differences between UC and CD. Recent advances in genetics have identified new components in the pathogenesis, as an example, the importance of Th17 lymphocytes and the IL-17/IL-23 pathway have been highlighted in both diseases, apart from the previously known Th1-Th2 driven processes. Genetic background of increased permeability has been explored in UC, and the role of defective autophagy was recently described in CD. Genetic alterations can lead to an exaggerated immune response to the resident microbial flora. This microflora is altered in IBD patients, probably due to their reduced ability to stabilize its bacterial components and due to different environmental factors. An exhaustive exploration of environmental factors is particularly important, as they can be influential in many cases. The impact of smoking is the most established environmental factor, having deleterious effects in CD and protective in UC. Recent opinions on other factors, such as early appendectomy, diet, reduced vitamin D levels, the use of specific medications, breastfeeding, personal hygiene and psychological factors are also discussed. Epigenetics, a new field of research, links environmental factors to genetics. Understanding these factors is of great significance as changing lifestyles and improving life circumstances have started to increase the prevalence of IBD also in developing countries.

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Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry

Cited by 90 publications

References 27 publications

Is Clostridium difficile Associated With Relapse of Inflammatory Bowel Disease? Results From a Retrospective and Prospective Cohort Study in the Netherlands

Is Clostridium difficile Associated With Relapse of Inflammatory Bowel Disease? Results From a Retrospective and Prospective Cohort Study in the Netherlands

Inflammatory Bowel Disease and Sexual Function in Male and Female Patients: An Update on Evidence in the Past Ten Years

Pathogenesis of Ulcerative Colitis and Crohn’s Disease: Similarities, Differences and a Lot of Things We Do Not Know Yet

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