Clinical Studies of Induction Agents Xxiv: The Influence of Anaesthesia With Thiopentone and Propanidid on the Blood Sugar Level

Clarke, R.S.J.

doi:10.1093/bja/40.1.46

Cited by 17 publications

(6 citation statements)

References 6 publications

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“…In the present study the plasma cortisol was estimated on the day of operation before premedication. Our findings on the effect of anaesthesia without surgery accord with those of Oyama et al (1969) and Clarke, Johnston and Sheridan (1970). After 30 and 60 min of anaesthesia and surgery there were mean increases of 2.8 and 11.4 fig/ 100 ml which when compared with the increases recorded by Clarke, Johnston and Sheridan (1970) on a group of patients who had infra-abdominal surgery are very small.…”

Section: Discussionsupporting

confidence: 85%

“…Our findings on the effect of anaesthesia without surgery accord with those of Oyama et al (1969) and Clarke, Johnston and Sheridan (1970). After 30 and 60 min of anaesthesia and surgery there were mean increases of 2.8 and 11.4 fig/ 100 ml which when compared with the increases recorded by Clarke, Johnston and Sheridan (1970) on a group of patients who had infra-abdominal surgery are very small. Similar small mean increases of 3.0 and 6.7 /ig/100 ml were recorded by Oyama et al (1969) at 30 and 60 min during different types of surgical procedures.…”

Section: Discussionsupporting

confidence: 85%

“…There have been several studies on the effect of different anaesthetic agents and surgical procedures on blood sugar concentration and the various reports have been reviewed by Clarke (1973). However, a few observations on the results of the present study merit discussion.…”

Section: Discussionmentioning

confidence: 70%

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Metabolic Response to Anaesthesia and Upper Abdominal Surgery in Nigerians: Changes in Plasma Cortisol, Insulin and Blood Sugar

Magbagbeola¹,

Adadevoh²

1974

British Journal of Anaesthesia

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In 10 Nigerian patients undergoing upper abdominal surgery the plasma cortisol concentration was slightly decreased after premedication with pethidine and atropine, and during anaesthesia without surgery. There was a small increase during surgery. None of these changes was statistically significant. There was a significant increase in the postoperative period however. Premedication caused a slight increase in blood sugar which remained steady during anaesthesia. There was a significant increase after 30 and 60 rnin of surgery, with a peak value at 60 min after operation. There were no significant changes in the mean values of plasma insulin concentration throughout the period of study. In a recent review of the world literature on anaesthesia and carbohydrate metabolism, Clarke (1973) concluded that Europeans and Japanese show a significant hyperglycaemic response to trauma under all types of anaesthesia, though it is less marked than the response of Jamaicans or Indians. This conclusion was based on the studies by Keating (1958) on Jamaicans, Cullingford (1966) on Indians, Clarke (1968 and 1970) on Europeans, and Oyama and Takazawa (1971a). Earlier reports by Barnicot and Wolffson (1952); Monnet, Baylet, and Reynaud (1952); Stirling and Keating (1958); and Phillips and Cohen (1959) indicated that the adrenal glands in Africans are less active than those of Europeans. However, recent studies of basal plasma cortisol concentrations in East and West

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 85%

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Metabolic Response to Anaesthesia and Upper Abdominal Surgery in Nigerians: Changes in Plasma Cortisol, Insulin and Blood Sugar

Magbagbeola¹,

Adadevoh²

1974

British Journal of Anaesthesia

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“…Clarke (1968) and Allison et al, (1969) have suggested that the stress with anaesthesia and surgery lead to alteration in endocrine secretion of insulin antagonists such as growth hormone. Cortisol and catecholamine causing temporary diabetic state by gluconeogenesis and glycogenolysis as well as decrease in peripheral use of glucose (Desborough, 2000).…”

Section: Resultsmentioning

confidence: 99%

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Sharma¹,

Prasad²,

Kumar³

2017

Int.J.Curr.Microbiol.App.Sci

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“…On the other hand, it has been recognized for some time that general anesthesia may be associated with a rise in blood sugar. [16] Clarke et al . [17] focused on blood glucose levels in women having minor gynecological procedure under general anesthesia and found that with all agents, the blood sugar rose significantly, with a peak at 15 min.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic responses of exogenous epinephrine during mandibular third molar surgery

et al. 2012

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Background:The systemic effects attributable to the injection of dental local anesthetic solutions have been the subject of discussion for many years.Aim and Objective:The aim of the present study was to investigate the biochemical and hemodynamic effects of adrenaline in lignocaine local anesthetic solutions when used in clinical doses in patients undergoing third molar surgery under general anesthesia.Materials and Methods:Of the total 30 patients, 15 were given local anesthetic solution containing adrenaline and the other 15 were given the same without adrenaline. Hemodynamic and biochemical parameters were recorded at considerable intervals. The changes from the pre-local anesthetic (baseline) values with each treatment were compared by analysis of variance and Student's t-test. The changes within each treatment were compared by the paired t-test.Results and Conclusion:This study shows that exogenous adrenaline administration in clinical doses produces systemic effects even in conditions where the endogenous release of the catecholamines would be expected to be considerable.

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Clinical Studies of Induction Agents Xxiv: The Influence of Anaesthesia With Thiopentone and Propanidid on the Blood Sugar Level

Cited by 17 publications

References 6 publications

Metabolic Response to Anaesthesia and Upper Abdominal Surgery in Nigerians: Changes in Plasma Cortisol, Insulin and Blood Sugar

Metabolic Response to Anaesthesia and Upper Abdominal Surgery in Nigerians: Changes in Plasma Cortisol, Insulin and Blood Sugar

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Pharmacodynamic responses of exogenous epinephrine during mandibular third molar surgery

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