Clinical Studies on Polyunsaturated Fatty Acids and Antioxidants in African Children

Leichsenring, Michael; Bremer, H. J.; Ahmed, Hassan; Laryea, Maurice D.; Bello, AA; Lombeck, I.; Mayatepek, Ertan

doi:10.1007/978-3-0348-7432-8_40

Cited by 2 publications

(1 citation statement)

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“…In previous studies we have shown that the antioxidative capacity of children with kwashiorkor is seriously compromised. Erythrocyte glutathione and plasma tocopherol levels are insufficient, and significantly lower than in marasmus (7)(8)(9)19). Also, results from other studies indicate diminished antioxidative canacitv (20.…”

Section: Discussionmentioning

confidence: 92%

Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein–energy malnutrition

et al. 1995

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The fatty acid composition of plasma cholesterol esters, plasma phospholipids, erythrocyte phosphatidylcholine and erythrocyte phosphatidylethanolamine was investigated in severely malnourished Nigerian children with kwashiorkor (n = 12) and marasmus (n = 32). Normally nourished children from the same area (n = 23) served as controls. The malnourished children showed a significant reduction of highly polyunsaturated fatty acids in cholesterol esters, phospholipids and phosphatidylcholine. No differences between the groups were found in erythrocyte phosphatidylethanolamine. Children with kwashiorkor had lower levels of linoleic acid metabolites and docosahexaenoic acid than marasmic children. The results suggest that the kwashiorkor syndrome is associated with impaired desaturation and elongation of PUFA and/or increased lipid peroxidation.

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Section: Discussionmentioning

confidence: 92%