Clinical Studies with Traditional Chinese Medicine in the Past Decade and Future Research and Development

Jiang, Miao; Yang, Jing; Zhang, Chi; Liu, Baoyan; Chan, Kelvin; Cao, Hongxin; Lü, Aiping

doi:10.1055/s-0030-1250456

Cited by 98 publications

(54 citation statements)

References 109 publications

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“…Herbal products have long been used to prevent or treat diseases, including cancer (9)(10)(11)(12). Furthermore, certain anti-cancer therapeutic agents that are chemically produced originate from herbal products and their chemical characteristics are modified (7,(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

Woo

Kwon

et al. 2017

Biomedical Reports

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Abstract. Cancer remains a leading cause of mortality worldwide, therefore food products are being investigated for potential prevention or treatment strategies. The ingredient, barley grass extract (Hordeum vulgare L.; Bex) is used to prevent or ameliorate various types of disease. In cancer, Bex has been revealed to inhibit tumor growth. However, its effect on cancer cells is yet to be clearly defined. In the present study, the effect of Bex on cancer cell growth was investigated. Bex inhibited the viabilities of breast and prostate cancer cells according to the results of MTT assays. Accordingly, Bex caused apoptosis, which was confirmed by Annexin V staining and western blot analysis for poly (ADP-ribose) polymerase and caspases. Furthermore, Bex increased the intracellular levels of reactive oxygen species (ROS), and N-acetyl-L-cystein blocked Bex-induced apoptosis. Therefore, the study demonstrated that Bex causes apoptosis of breast and prostate cancer cells by increasing intracellular ROS levels. IntroductionCancer is one of the leading causes of mortality worldwide (1,2). Despite numerous cancer studies and the development of various anti-cancer therapeutic agents, cancer remains dangerous. Anti-cancer therapeutic agents are chemically or biologically produced, and their effects are well defined (3-7). However, treatments continue to be associated with adverse effects and the majority of patients have an aversion to them (8).Herbal products have long been used to prevent or treat diseases, including cancer (9-12). Furthermore, certain anti-cancer therapeutic agents that are chemically produced originate from herbal products and their chemical characteristics are modified (7,(12)(13)(14). Typically, patients prefer to take herbal products (15-18); herbal products have historically been used as traditional medicines, such as traditional Chinese and Korean medicines, Kampo medicines and Ayurvedic medicine (13,14,19). Certain herbal products were demonstrated to treat cancer and/or reduce the side effects of cancer treatment (13,(15)(16)(17)(19)(20)(21). Therefore, herbal products are considered to be promising for cancer prevention and treatment.Barley grass extract (Hordeum vulgare L.; Bex) has long been used as a food product. Its biological effects have also been addressed by various in vitro and in vivo studies, although evidence there is limited evidence of the efficacy of Bex against specific conditions (22). The effect of Bex on the immune system was revealed in in vitro and in vivo experimental sets (23-25). Accordingly, Bex inhibited atopic dermatitis in NC/Nga mice by altering the expression levels of cytokines (26). Similarly, Bex repressed lipopolysaccharide-induced inflammation (27). Furthermore, its effect in type 2 diabetes was revealed in a genetically engineered mouse model and patients (28,29). Therefore, the effects of Bex on particular diseases have been demonstrated at least in experimental systems. A previous study revealed that Bex caused apoptosis of leukemia and lymphoma cell lines...

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Section: Introductionmentioning

confidence: 99%

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

Woo

Kwon

et al. 2017

Biomedical Reports

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“…It has become an indisputable fact that the treatment of primary liver cancer in advanced stage is characterized by poor clinical efficacy and adverse outcome, and the therapeutic efficacy of the combination treatment of CTM and western medicine for this critical ill is to be further evaluated by the evidence-based medicine [7]. Currently, the treatment of CTM for the advanced primary liver cancer has rarely been reported [8].…”

Section: Introductionmentioning

confidence: 99%

Therapy Response of Chinese Herbal Medicine in Advanced Liver Cancer: A Retrospective Observational Clinical Trial

Lv¹,

Zhu²,

Wan³

et al. 2016

JPP

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Aiming at starting the ball rolling and contributing humble effort to promote CTM (Chinese traditional medicine), we performed the present study to assess the therapy response of Chinese herbal decoction compared to conventional therapy on critical ill patients of advanced liver cancer. A total of 6 patients (1 female and 5 males) with histologically confirmed liver cancer were included in this retrospective observational clinical trial. We administered Chinese medicine (Gan Decoction, mixed with a variety of effective herbal components) to help them to recover from poor condition. In the meantime, conventional treatment of surgical resection and artery catheterization chemotherapy was applied in cases compared. In 3 cases of CTM combined treatment, the tumor marker level decreased. Residual intrahepatic metastatic sites reduced according to ultrasonography/CT imaging, and the patients felt free from the complaint of abdominal discomfort. The quality of life has been improved, we managed to have prolonged the PFS (Progression-Free-Survival) and TTP (Time-to-Progression) from the onset to date. While in 3 cases with conventional treatment only of surgical resection and artery catheterization chemotherapy, we were not able to decrease the level of tumor marker, metastatic lesions increased according to ultrasonography/CT imaging, and the patient's condition worsen more. We failed in having prolonged the PFS and TTP in the compared cases of conventional treatment only. The retrospective clinical study showed no OS (overall survival) benefit for liver cancer patients treated with Gan Decoction, while the QOL (quality of life) evaluation seemed to predict survival better. Chinese herbs might be an additional choice with its better benefits and tolerability in the treatment of primary liver cancer.

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“…Although studies confirmed the efficacies of TCM (Jiang et al, 2010;Li and Peng, 2013), its pharmacological basis remains largely under investigation. Uncovering the relationships between the active ingredients and molecular targets is the principal and basic issue for transforming TCM into evidence-based medicine.…”

Section: Introductionmentioning

confidence: 99%

Prevention of secretory diarrhea by ethanol extract of <i>Bistortae rhizoma</i> through inhibition of chloride channel

B¹,

Jiang²,

Liu³

et al. 2015

Bangladesh J Pharmacol

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Inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and Ca 2+ -activated Cl -channel (CaCC) represents an attractive approach for the treatment of secretory diarrhea. The aim of the study is to investigate the molecular basis of the anti-diarrheal effect of traditional Chinese herbal antidi -arrheal medicine Bistortae rhizoma. Fluorescence quenching assay indicated that the 40% methanol /water fraction (D5) dose-dependently inhibited both CFTR and CaCC function in transfected Fischer rat thyroid (FRT) cells. Ex vivo studies indicated that D5 inhibited both forskolin (FSK)-activated CFTR current and CCh-induced CaCC current in rat colonic mucosa. In the mouse closed-loop model, intraluminal application of D5 (200 µg/mL) significantly reduced cholera toxin-stimulated fluid secretion. In the intestinal motility model, D5 significantly delayed intestinal peristalsis in mice. Our research suggests that CFTR and CaCC-mediated intestinal epithelial Cl -secretion inhibiting and gastrointestinal motility delaying may account for the antidiarrheal activity of B. rhizoma.

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Clinical Studies with Traditional Chinese Medicine in the Past Decade and Future Research and Development

Cited by 98 publications

References 109 publications

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production

Therapy Response of Chinese Herbal Medicine in Advanced Liver Cancer: A Retrospective Observational Clinical Trial

Prevention of secretory diarrhea by ethanol extract of <i>Bistortae rhizoma</i> through inhibition of chloride channel

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