Clinical Study Evaluating the Desensitizing Effect and Duration of Two Commercially Available Dentifrices

Hernandez, Francisco; Mohammed, Clive I.; Shannon, Ira L.; Volpe, A R; King, William

doi:10.1902/jop.1972.43.6.367

Cited by 36 publications

(13 citation statements)

References 2 publications

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“…The anti-caries effectiveness of commercially available dentifrices containing 0.76% sodium monofiuorophosphate has been well documented in many clinical investigations (Accepted Dental Therapeutics 1971/1972). Furthermore, several clinical investigations (Bolden et al 1968, Hazen et al 1968, Kanouse & Ash 1969, Hernandez et at. 1972 have indicated that this dentifrice is also effective in the treatment of hypersensitive Jeeth.…”

Section: Sodium Monofluorophosphalementioning

confidence: 99%

“…Therapies employed to relieve this condition have relied upon the astringent or coagulating effects of various agents, the occluding proper-ties of others, or the ability to render calcium less soluble (BHtzer 1967). Amongst the most common agents now being used, the literature contains references to the efficacy of strontium chloride (Cohen 1961,Skurnik 1963,Meffert& Hoskins 1964, Blitzer 1967, Shapiro et al 1970a, b, Carrasco 1971, Hernandez et al 1972, Uchida et ai. 1980, sodium monofluorophosphate (Bolden et al 1968, Hazen et al 1968, Kanouse & Ash 1969, Shapiro et al 1970b), sodium fluoride (Hoyt & Bibby 1943, Minkov et al 1975, sodium fluoride using iontophoretic techniques (Murthy et al 1973, Minkov et al 1975, Gangarosa 1981, calcium hydroxide (Levin et al 1973, Brannstrom et al 1976, Green et al 1977, calcium sucrose phosphate-calcium orthophosphate complex (Craig 1973), potassium nitrate (Hodosh 1974, Green et al 1977, Tarbet et al 1980, formaldehyde (Forrest 1963, Smith & Ash 1964, sodium citrate pluronic gel (Zinner et al 1977), stannous fluoride (Miller et al 1969, Zinner etal.…”

mentioning

confidence: 99%

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Dentine hypersensitivity ‐ A review

Addy

Dowell

1983

J Clinic Periodontology

144

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A large number of compounds have been employed in the management of dentine hypersensitivity. The symptomatic nature of the condition and its variability poses many problems to any evaluation of effect. Several semi-quantitative methods of response have been used; however, at this time it is uncertain what advantages they hold over the patients' subjective assessment of improvement. A review of the clinical studies reveals that a positive result for every agent tested to date may be found. Nevertheless considerable placebo responses have been obtained and equivocal results are occasionally reported. The fluorides and metal salts, particularly of strontium, have been most studied when used either in solution or delivered in toothpaste formulations. For these compounds the literature contains considerable information concerning the reaction with dental hard tissues which can be extrapolated into hypotheses for the modes of action in relieving dentine hypersensitivity. Moreover, some in vitro studies provide useful information concerning the effects of certain compounds on dentine, and are consistent with the clinical data. Unfortunately, contradictory findings and anomalies between clinical and in vitro effects still prevent the development of a sound clinical basis for the treatment of the condition. Moreover, there is a need to recognise those factors which predispose to dentine exposure, if the prevention of the occurrence or re-occurrence of hypersensitivity is to be achieved.

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Section: Sodium Monofluorophosphalementioning

confidence: 99%

mentioning

confidence: 99%

Dentine hypersensitivity ‐ A review

Addy

Dowell

1983

J Clinic Periodontology

144

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show abstract

“…A range of preparations designed to relieve this condition have relied upon the astringent or coagulating effects of some agents, the occluding properties of others, or the ability to render calcium less soluble (Blitzer, 1967). Amongst others, the literature contains reference to the efficacy of strontium chloride (Hernandez et a/., 1972;Uchida et al, 1980), sodium monofluorophosphate (Shapiro et ai, 1970), sodium fluoride (Minkov et al, 1975), stannous fluoride (Miller et al, 1969) and zinc chloride (Hunter, Barringer & Spooner, 1961). The compounds have in clinical trials shown variable effectiveness, depending upon the evaluation criteria used.…”

Section: Introductionmentioning

confidence: 99%

Dentine hypersensitivity: effect of interactions between metal salts, fluoride and chlorhexidine on the uptake by dentine

Addy

Dowell

1986

J of Oral Rehabilitation

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A large number of compounds may be applied to the teeth for preventive or therapeutic purposes, most notably in dentine hypersensitivity. The uptake of any one compound by tooth substances may clearly be affected by another to produce synergistic, additive or antagonistic effects. This study determined whether uptake interactions occurred between fluoride, chlorhexidine, strontium, tin and zinc. All compounds, in particular tin, showed considerable affinity for dentine. Fluoride reduced the uptake of zinc but not tin, strontium or chlorhexidine. Chlorhexidine increased the uptake of zinc, but not tin, strontium or fluoride. Zinc and tin decreased fluoride uptake but strontium had no such effect. Finally, chlorhexidine uptake was increased by zinc and tin but not by fluoride or strontium. Based on the theories proposed for the reaction of these various compounds with calcified tissues, explanations for the interactions can be made. The results appear relevant to some reported clinical effects of combinations of these compounds and indicate that such interactions may have advantageous or disadvantageous consequences depending on the basis for treatment.

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“…Untersuchungen zeigten gute Ergebnisse nach täglicher Anwendung strontiumchloridhaltiger Zahnpasten über einen längeren Zeitraum [19,39]. …”

Section: Niedermolekulare Ionische Verbindungenunclassified

Erste Erfahrungen mit HYPOSEN zur Therapie der Dentinhypersensibilität

Gernhardt¹,

Schaller²

2005

ZWR

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Die Therapie der Dentinhypersensibilität ist nach wie vor ein klinisch äußerst interessantes Thema. Der vorliegende Beitrag stellt erste klinische Erfahrungen mit dem neuen strontiumchloridhaltigen Desensibilisierungsmedikament HYPOSEN vor. Ferner werden erste Ergebnisse einer klinischen Untersuchung, die den Erfolg bei der Behandlung überempfindlicher Zahnflächen in einer prospektiven Untersuchung testete, vorgestellt. Diese Studie zeigt einen signifikant positiven Einfluss der Therapie mit HYPOSEN auf klinische Beschwerden der Patienten.

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Clinical Study Evaluating the Desensitizing Effect and Duration of Two Commercially Available Dentifrices

Cited by 36 publications

References 2 publications

Dentine hypersensitivity ‐ A review

Dentine hypersensitivity ‐ A review

Dentine hypersensitivity: effect of interactions between metal salts, fluoride and chlorhexidine on the uptake by dentine

Erste Erfahrungen mit HYPOSEN zur Therapie der Dentinhypersensibilität

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