Clinical Study of a New Antikeloid Agent

Bossé, Jean-Paul; Papillon, Joan; Frenette, Gilles; Dansereau, J.; Cadotte, M; Lorier, Jacques Le

doi:10.1097/00000637-197907000-00002

Cited by 7 publications

(8 citation statements)

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“…Moisturizing effect of aloe vera extract can reduce inflammatory response and itching (Davis and Maro, 1989;Heggers et al, 1996). Bosse et al (1979) reported that there was 72% improving from using Centella asiatica with surgery in scar management. After local application to a sutured wound of this herb significantly induces the breaking strength of the wound so it might reduce hardness of the scar.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Muangman¹,

Aramwit

Palapinyo³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The development of hypertrophic scars is an unsolved problem in the process of wound healing. The objective of this research was to study the efficacy of the combination of herbal extracts and a silicone derivative in a gel preparation (Cybele ® Scagel) on the treatment of deep second degree burns after complete epithelialization. Sixty-three patients were enrolled in this study. One wound area larger than 10 × 10 cm was selected from each patient to receive treatment with Cybele ® Scagel. Patients were observed for pigmentation, pliability, pain and itching for 0, 2, 4, 8, 12, 16, 20 and 24 weeks after treatment. Their data and wound characteristics were collected during each visit using the Vancouver scar scale. After 24 weeks, all scales (pigmentation, pliability, pain and itching) were significantly lower in the sites treated with Cybele ® Scagel compared with the previous time points (p< 0.05). However, vascularity and height scale were not significantly different (p> 0.05). One patient was excluded at week 2 because of moderate itching at the wound site, which could have interfered with the evaluation. The application of Cybele ® Scagel might have some beneficial effects for prevention of hypertrophic scar formation after partial thickness burn injuries.

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Section: Discussionmentioning

confidence: 99%

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Muangman¹,

Aramwit

Palapinyo³

et al. 2011

Afr. J. Pharm. Pharmacol.

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“…Negligible amounts of the proposed active metabolites, madecassic and asiatic acids, were detected in rat plasma, and, unexpectedly, we found a bidirectional interconversion between madecassoside and asiaticoside [13]. Both triterpenoid glycosides were mainly excreted via the hepatobiliary system, and were extensively biotransformed into their respective triterpenic acids, madecassic and asiatic acids, likely by normal flora in the gastrointestinal tract [14,15]. Interestingly, in relation to the pharmacokinetics of its respective single compounds, an increased exposure of the two triterpenoid glycosides present in ECa 233 was observed.…”

Section: Introductionmentioning

confidence: 58%

Comparison of the Pharmacokinetic Profiles of a Standardized Extract of Centella asiatica and A Mixture of Madecassoside and Asiaticoside in Rats

Khemawoot

Hengjumrut

Anukunwithaya

et al. 2018

PMIO

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Centella asiatica is a tropical plant commonly used as an herbal remedy in traditional medicines in many countries. In an attempt to establish an herbal extract with well-defined characteristics, a standardized extract of C. Asiatica, ECa 233, was developed. This extract contains at least 80% triterpenoid glycosides with the major constituents madecassoside and asiaticoside at a ratio of 1.5±0.5:1. In the present study, comparative pharmacokinetics of ECa 233 with its mixture of madecassoside and asiaticoside were conducted in rats. Following intravenous or oral administration of the test compounds, blood, tissues, urine, and feces were collected for the determination of madecassoside, asiaticoside, and their metabolite levels using liquid chromatography tandem mass spectrometry. Plasma levels of madecassoside and asiaticoside in the ECa 233-treated group were found to be higher than their respective counterparts in the mixture. Madecassoside and asiaticoside in both test formulae appeared to be widely distributed in several organs, and more than 50% of the administered doses were recovered as madecassic acid and asiatic acid in the feces within 24 to 48 h. The results clearly demonstrated the pharmacokinetic advantage of a standardized extract of C. Asiatica, ECa 233, compared with a mixture of madecassoside and asiaticoside at an equivalent amount. Other minor constituents that naturally exist in ECa 233 appeared to positively modulate the pharmacokinetics of its major constituents, resulting in relatively better pharmacokinetic profiles than those from a mixture of pure compounds.

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“…However, studies have examined gotu kola's ability to regulate fibrosis in patients with conditions such as progressive systemic sclerosis and keloid scars. 14,15 Laboratory studies clearly show the herb can regulate collagen synthesis. 16 The side-benefits of gotu kola are that it is stress-relieving, inflammation-modulating, and immune-modulating, making it a broad-acting, potentially very beneficial herb for patients with chronic prostatitis.…”

Section: "Leaky Prostate Syndrome"mentioning

confidence: 99%

Natural Approaches to Treating Chronic Prostatitis and Chronic Pelvic Pain Syndromes

Yarnell

Abascal

2005

Alternative and Complementary Therapies

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C hronic prostatitis and chronic pelvic pain affect a significant number of men in the western world. The various factors that appear to play a role in its pathogenesis, including breakdown in the urine-prostate barrier ("leaky prostate syndrome"), chronic inflammation, the role of infectious organisms, and autoimmune and other pathologic factors are considered.Various natural therapies to address these problems are discussed,

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Clinical Study of a New Antikeloid Agent

Cited by 7 publications

References 0 publications

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury

Comparison of the Pharmacokinetic Profiles of a Standardized Extract of Centella asiatica and A Mixture of Madecassoside and Asiaticoside in Rats

Natural Approaches to Treating Chronic Prostatitis and Chronic Pelvic Pain Syndromes

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