Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation

Katagiri, Wataru; Watanabe, Junna; Toyama, Naoto; Osugi, Masashi; Sakaguchi, Kohei; Hibi, Hideharu

doi:10.1097/id.0000000000000618

Cited by 69 publications

(52 citation statements)

References 29 publications

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“…The study revealed a significant increase in bone formation, with respect to bone volume in the individuals treated with BMSC‐CM. The positive effects observed during the study were attributed towards the presence of IGF‐1, TGF‐β1 and VEGF of the BMSC secretome (Katagiri et al, ). BMSC‐CM have also been used in combination with BMSCs for phase I/IIa clinical trials for the treatment of multiple sclerosis.…”

Section: Paracrine Action Of Conditioned Media In Clinical Applicationsmentioning

confidence: 99%

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

Gunawardena

Rahman

Abdullah

et al. 2019

J Tissue Eng Regen Med

117

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Recent studies suggest that the main driving force behind the therapeutic activity observed in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These biomolecules also trigger antiapoptotic events to prevent further degeneration of the diseased organ through paracrine signalling mechanisms. In comparison with the normal physiological conditions, an increased paracrine gradient is observed within the peripheral system of diseased organs that enhances the migration of tissue-specific MSCs towards the site of infection or injury to promote healing.Thus, upon administration of conditioned media derived from mesenchymal stem cell cultures (MSC-CM) could contribute in maintaining the increased paracrine factor gradient between the diseased organ and the stem cell niche in order to speed up the process of recovery. Based on the principle of the paracrine signalling mechanism, MSC-CM, also referred as the secretome of the MSCs, is a rich source of the paracrine factors and are being studied extensively for a wide range of regenerative therapies such as myocardial infarction, stroke, bone regeneration, hair growth, and wound healing. This article highlights the current technological applications and advances of MSC-CM with the aim to appraise its future potential as a regenerative therapeutic agent.

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Section: Paracrine Action Of Conditioned Media In Clinical Applicationsmentioning

confidence: 99%

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

Gunawardena

Rahman

Abdullah

et al. 2019

J Tissue Eng Regen Med

117

View full text Add to dashboard Cite

show abstract

“…This concept is based on observations that a very small fraction of implanted MSCs survives long enough in vivo to differentiate, suggesting that MSCs mainly exert their regenerative effects via paracrine mechanisms (Haumer et al., ). Following promising pre‐clinical results, one group has recently reported the clinical application of allogeneic MSCs conditioned medium, in combination with β‐TCP or COL sponge scaffolds, for bone regeneration in SA, RA and SP, in nine patients with favourable outcomes and no adverse events (Katagiri, Osugi, Kawai, & Hibi, ; Katagiri et al., ). The safety and efficacy of allogeneic MSCs secretome (lyophilised) as an “off‐the‐shelf” therapy for bone regeneration should be investigated in future clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Cell therapy for orofacial bone regeneration: A systematic review and meta‐analysis

Shanbhag

Suliman

Pandis

et al. 2019

J Clinic Periodontology

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Aim The objective of the present review was to answer the focused question: what is the effect of cell therapy in terms of orofacial bone regeneration compared to grafting with only biomaterial scaffolds and/or autogenous bone? Methods Electronic databases were searched for relevant controlled clinical and pre‐clinical (large‐animal) studies. Separate meta‐analyses of quantitative data regarding histological or radiographic new bone formation were performed. Results Forty‐seven eligible clinical and 57 pre‐clinical studies were included. Clinical studies were categorized based on the use of “minimally manipulated” whole tissues (e.g., bone marrow) or ex vivo expanded cells from “uncommitted” (bone marrow, adipose tissue) or “committed” sources (periosteum, bone). Based on limited and heterogeneous clinical evidence, implantation of cells (mostly whole bone marrow), in combination with biomaterial scaffolds results in bone regeneration which is (a) superior compared to implantation of scaffolds alone in sinus and horizontal ridge augmentation, and (b) comparable to autogenous bone in alveolar cleft repair. Conclusions Although current evidence points to the benefits of cell therapy in certain clinical indications, it is unclear whether the use of ex vivo expanded cells, either uncommitted or committed, is superior to whole tissue fractions in terms of bone regeneration. The relatively larger effect sizes in favour of cell therapy observed in pre‐clinical studies are diminished in clinical trials. Future controlled studies should include cost‐effectiveness analyses to guide clinical decision‐making.

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“…Secretome-based approaches using CM may present osteogenic potential advantages over living cells regarding manufacturing, storage, handling, product shelf life and their potential as a ready-to-go biological therapeutic agent [34][35][36][37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Role of Mesenchymal Stem Cell-Conditioned Medium (MSC-CM) in the Bone Regeneration: A Systematic Review from 2007-2018

Dilogo

Fiolin

2019

ARRB

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Background: The therapeutic value of mesenchymal stem cells (MSCs) in tissue engineering and regenerative medicine is attributable in part to paracrine pathways triggered by several secreted factors secreted into culture media. The secreted factor here is known as the conditioned medium (CM) or secretome. Objectives: This review is aimed to investigate and summarise the in-vitro, pre-clinical in-vivo studies regarding the role of CM-MSC in bone regeneration from 2007 until 2018 Data Sources: A systematic literature search on PubMed, MEDLINE, OVID, Scopus and Cochrane library was carried out by using search terms: Secretome, conditioned medium, mesenchymal stem cell, bone healing, osteogenic, osteogenesis. Methods: A total of 611 articles were reviewed. Ten articles were identified as relevant for this systematic literature review. Results: Three tables of studies were constructed for in vitro studies and in-vivo studies. Conclusion: All of the included in-vitro studies and in-vivo studies have shown a promoting effect of bone regeneration at various stages. Although there are no clinical studies regarding the use of CM-MSC in the human bone regeneration that have been conducted, transplantation of secretome has shown a promising result in the acceleration of bone healing process.

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Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation

Abstract: The secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) was used safely and has great osteogenic potential for regenerative medicine of bone.

Cited by 69 publications

References 29 publications

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

Cell therapy for orofacial bone regeneration: A systematic review and meta‐analysis

Role of Mesenchymal Stem Cell-Conditioned Medium (MSC-CM) in the Bone Regeneration: A Systematic Review from 2007-2018

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