Clinical Study of MEBO Combined with Jinhuang Powder for Diabetic Foot with Infection

Objective. To determine the role of Jinhuang Powder to prevent adverse effects of subcutaneous injection of enoxaparin sodium. Methods. The clinical data of 97 patients with cervical cancer who were treated with subcutaneous injection of enoxaparin through the lower margin of the deltoid muscle of the upper arm in Zhejiang Tumor Hospital from August 2020 to August 2021 were retrospectively analyzed. All patients were divided into the control group (n = 39) and the research group (n = 58) according to the different use time periods of Jinhuang Powder. The research group was treated with Jinhuang Powder and enoxaparin sodium at the same time. The control group started to use Jinhuang Powder after the adverse reactions occurred. The induration, subcutaneous bleeding events, and pain were statistically analyzed. Results. The incidence of induration (3.4% vs 15.4%, P = 0.036 ) and subcutaneous hemorrhage (37.9% vs 76.9%, P = 0.003 ) in the research group was significantly lower than that in the control group. The pain in the research group was lighter than that in the control group (grade 0–4 pain: 70% vs 28.2%, 19% vs 30.8%, 8.6% vs 23.1%, 1.7% vs 12.8%, 1.7% vs 5.1%, P = 0.001 ). Conclusion. Preventive use of Jinhuang Powder can significantly reduce the incidence of subcutaneous induration and subcutaneous bleeding and can effectively alleviate the local pain of injection. It is worthy of further study to clarify its role and mechanism.

show abstract

“…e liquid medicine is brought into the eye of the needle with the needle tip, irritating the skin and causing bleeding [7]. [8].…”

Section: How To Use Jinhuang Powder 8 G Of Jinhuang Powdermentioning

confidence: 99%

The Role of Jinhuang Powder to Prevent Adverse Effects of Subcutaneous Injection of Enoxaparin Sodium

Zhang

Wang

et al. 2022

Emergency Medicine International

View full text Add to dashboard Cite

show abstract

“…A total of 657 distinctive studies were found, of which 25 studies (between 1988 and 2022) satisfied the inclusion criteria and were comprised in the study. 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 The 25 studies included 1777 subjects with cancer‐related symptoms at the start of the study; 953 of them were provided with Chinese herbal medicines and 824 were control. All studies evaluated the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia.…”

Section: Resultsmentioning

confidence: 99%

“…This meta‐analysis study based on 25 studies included 1777 subjects with cancer‐related symptoms at the start of the study; 953 of them were provided with Chinese herbal medicines and 824 were control. 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 Chinese herbal medicines had significantly higher effectiveness in treating pressure ulcer wound, fatigue, and constipation compared to control in subjects with cancer‐related symptoms. However, Chinese herbal medicines had no significant effect on treating anorexia compared to control in subjects with cancer‐related symptoms.…”

Section: Discussionmentioning

confidence: 99%

The influence of Chinese herbal medicines on cancer‐related pressure ulcer wound, fatigue, constipation, and anorexia: A meta‐analysis

Liu²

2022

International Wound Journal

View full text Add to dashboard Cite

We performed a meta‐analysis to evaluate the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia. A systematic literature search up to March 2022 was done and 25 studies included 1777 subjects with cancer‐related symptoms at the start of the study; 953 of them were provided with Chinese herbal medicines and 824 were control. They were reporting relationships about the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) to assess the influence of Chinese herbal medicines on cancer‐related pressure ulcer wounds, fatigue, constipation, and anorexia using the dichotomous method with a random or fixed‐effect model. Chinese herbal medicines had significantly higher effectiveness in treating pressure ulcer wound (OR, 5.94; 95% CI, 3.94‐8.95, P < .001), fatigue (OR, 2.81; 95% CI, 1.78‐4.41, P < .001), and effectiveness on treating constipation (OR, 2.59; 95% CI, 1.57‐4.25, P < .001) compared to control in subjects with cancer‐related symptoms. However, Chinese herbal medicines had no significant effect on treating anorexia (OR, 1.69; 95% CI, 0.61‐4.66, P = .31) compared to control in subjects with cancer‐related symptoms. Chinese herbal medicines had significantly higher effectiveness in treating pressure ulcer wound, treating pressure ulcer wound, fatigue, and constipation compared to control in subjects with cancer‐related symptoms. However, Chinese herbal medicines had no significant effect on the effectiveness of treating anorexia compared to control in subjects with cancer‐related symptoms. Further studies are required to validate these findings.

show abstract

Section: To the Editormentioning

confidence: 99%

“…This is a comment on “This is a comment on “Clinical Study of moist exposed burn ointment (MEBO) Combined with Jinhuang powder for Diabetic Foot with Infection”[ 1 ]. We were pleased that read the research article by Hong-Bo Zhan, et al [ 1 ]. Their work highlights that the use of Jinhuang powder as supplement combined with MEBO as an effective and safe therapy for diabetic foot.…”

Section: To the Editormentioning

confidence: 99%

More studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot

Yan

et al. 2022

WJD

View full text Add to dashboard Cite

Diabetes mellitus is a common global public health problem that can cause serious illness and premature death. Diabetic foot ulcer, one of the complications of diabetes, is a major cause of morbidity and mortality and is associated with many other devastating complications. Previous study found that a group of traditional Chinese medicine (TCM) can be used for treating diabetic foot ulcers. More and more attention is being paid to the use of Chinese medicine to heal diabetic feet. Under the guidance of relevant theories of traditional Chinese medicine, more studies are needed to reveal the key active components and related signal pathways of TCM in the treatment of diabetic foot ulcer. One clinical study explored the treatment of diabetic foot with infection combined moist exposed burn ointment with Jinhuang powder. However, large-scale multi-center, double blind, randomized, placebo-controlled clinical trials and animal studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot.

show abstract

Clinical Study of MEBO Combined with Jinhuang Powder for Diabetic Foot with Infection

Cited by 9 publications

References 12 publications

The Role of Jinhuang Powder to Prevent Adverse Effects of Subcutaneous Injection of Enoxaparin Sodium

The Role of Jinhuang Powder to Prevent Adverse Effects of Subcutaneous Injection of Enoxaparin Sodium

The influence of Chinese herbal medicines on cancer‐related pressure ulcer wound, fatigue, constipation, and anorexia: A meta‐analysis

More studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot

Contact Info

Product

Resources

About