Clinical study of the radioprotective effects of amifostine (YM-08310, WR-2721) on chronic radiation injury

Takahashi, Iku; Nagai, Teruo; Miyaishi, Kazuo; Maehara, Yasunobu; Niibe, Hideo

doi:10.1016/0360-3016(86)90388-3

Cited by 59 publications

(18 citation statements)

References 2 publications

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“…Morphological and physiological studies have identified the renal tubule system as the site of maximum radiation damage [3,6,10,11,14,28,[31][32][33]. According to the results of our study, tubular toxicity induced by 6-Gy irradiation was seen over a period of 6 months.…”

Section: Discussionmentioning

confidence: 54%

“…The protective effect of amifostine against ionizing radiation has already been shown on salivary glands, bone marrow and lungs using scintigraphic methods [2,4,28,30]. However, to the best of our knowledge, there is no published data in the literature presenting a protective effect of amifostine on renal parenchymal tissue against ionizing radiation via static or dynamic renal scintigraphy.…”

Section: Discussionmentioning

confidence: 96%

“…The substance selectively protects normal cells from radiation and antineoplastic drug toxicity by scavenging free radicals, donating hydrogen ions to free radicals, depleting oxygen, and by binding to active derivatives of antineoplastic agents [6,13]. The important nephroprotective effect of amifostine has been reported in the literature [10,12,28,29,31,33].…”

Section: Discussionmentioning

confidence: 99%

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Amifostine Use in Radiation-Induced Kidney Damage

et al. 2008

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Amifostine Use in Radiation-Induced Kidney Damage

et al. 2008

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“…Considerable interest has recently been expressed in the use of phosphorylthioate drugs as adjuvants to radiotherapy (Kligerman et al, 1980(Kligerman et al, , 1984Takahasi et al, 1986). This interest is based upon an early observation by Yuhas and Storer, (1969) that WR-2721 differentially protects normal as compared to tumour cells.…”

mentioning

confidence: 99%

The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells

Sigdestad¹,

Treacy²,

Knapp³

et al. 1987

Br J Cancer

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Summary Radiation induced DNA double strand breaks are believed to be important lesions involved in processes related to cell killing, induction of chromosome aberrations and carcinogenesis. This paper reports the effects of the radioprotector 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation-induced DNA damage and repair in V79 cells using the neutral elution method performed at pH 7.2 or pH 9.6. WR-1065 (4mM) was added to the culture medium either 30 minutes prior to and during irradiation with Cobalt-60 gamma rays (for dose response experiments) or during the repair times tested (for DNA rejoining experiments). The results indicate that WR-1065 is an effective protector against the formation of radiationinduced double-strand breaks in DNA as measured using a neutral elution technique at either pH. The protector reduced the strand scission factors by 1.44 and 1.77 in experiments run at pH 9.6 and pH 7.2, respectively.The kinetics of DNA double-strand rejoining were dependent upon the pH at which the neutral elution procedure was performed. Unlike the results obtained with alkaline elution, rejoining of DNA breaks was unaffected by the presence of WR-1065 at either pH.

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“…Histologische Untersuchungen am Kaninchen bestäti-gen dies, eine Lipomatose der Speicheldrüse tritt unter Amifostinschutz nicht auf [4]. Strnad et al [24] [1,6,9,19,20] konnten ebenfalls zeigen, dass Amifostin unter den Bedingungen einer Radiochemotherapie zu einer verminderten Mukositis und Xerostomie führt.…”

Section: Radioprotektive Wirkung Von Amifostinunclassified