Clinical Study of Ticrynafen

Nemati, Massoud

doi:10.1001/jama.1977.03270340038016

Cited by 41 publications

(5 citation statements)

References 2 publications

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“…Pulse rate was not affected by treatment. These results are similar to those reported by others studying the comparative antihypertensive effects of HCTZ vs. TCNF [9,21],…”

Section: Discussionsupporting

confidence: 92%

“…The use of TCNF, however, resulted in a significant decrease ( -2.5 mg/dl) in the serum uric acid, which was further decreased during P therapy. These results are similar to the reports of others comparing the effects of HCTZ vs. TCNF on serum uric acid [9,17,21,23],…”

Section: Comparative Effects On Biochemical Parameterssupporting

confidence: 92%

“…Although SUN was signi ficantly increased following TCNF, the mean SUN re mained within normal limits for our laboratory. These findings are similar to those previously reported on the comparative effects of HCTZ vs. TCNF on SUN, plasma creatinine, creatinine clearance, and PAH clearance [9,21].…”

Section: Comparative Effects On Renal Functionsupporting

confidence: 91%

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Comparative Effects of Ticrynafen and Hydrochlorothiazide on Blood Pressure, Renal Function, Serum Uric Acid and Electrolytes, and Body Fluid Spaces in Hypertensive Man

Bauer¹,

Brooks²

1979

Nephron

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25 hypertensive subjects underwent a double-blind, randomized study to compare the effects of ticrynafen (TCNF) with hydrochlorothiazide (HCTZ) on blood pressure (BP), renal function, serum uric acid (UA) and electrolytes, and body fluid spaces. BP was similarly lowered by TCNF and HCTZ. Neither TCNF nor HCTZ had a significant effect on true or regular creatinine, inulin, or PAH clearances. TCNF lowered UA, whereas HCTZ elevated UA. Both produced similar electrolyte disturbances. Neither TCNF nor HCTZ, according to our methods, had a significant effect on plasma volume, extracellular fluid, or total body water. The primary advantage of TCNF compared with HCTZ is its profound hypouricemic effect.

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“…Pulse rate was not affected by treatment. These results are similar to those reported by others studying the comparative antihypertensive effects of HCTZ vs. TCNF [9,21],…”

Section: Discussionsupporting

confidence: 92%

Section: Comparative Effects On Biochemical Parameterssupporting

confidence: 92%

See 1 more Smart Citation

Comparative Effects of Ticrynafen and Hydrochlorothiazide on Blood Pressure, Renal Function, Serum Uric Acid and Electrolytes, and Body Fluid Spaces in Hypertensive Man

Bauer¹,

Brooks²

1979

Nephron

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“…Ticrynafen is a diuretic-uricosuric drug which is also effective as an antihypertensive. 9 Most diuretics currently available are associated with hyperuricemia as a side effect of their use which is thought to be related to contraction of extracellular fluid volume and to competition with uric Ticrynafen. a uricosuric diuretic 459 acid by diuretics for a common secretory site.…”

Section: Discussionmentioning

confidence: 99%

Ticrynafen, a uricosuric antihypertensive diuretic

Stote

Dubb

Familiar

et al. 1978

Clin Pharma and Therapeutics

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Ticrynafen, a diuretic-uricosuric also effective as an antihypertensive, was compared in single doses with several other diuretics. Over an 8-hr period, a 250- mg dose exerted natriuretic activity comparable to that of 25 mg of chlorthalidone and 50 mg of ethacrynic acid; a 500-mg dose was comparable to 50 mg chlorthalidone and 50 mg hydrochlorothiazide. Ticrynafen combined with furosemide had an additive effect, whereas a combination with hydrochlorothiazide was not additive. In both doses ticrynafen was a uricosuric and this effect was maintained when given with furosemide and hydrochlorothiazide, both of which individually were slightly antiuricosuric. Ticrynafen may be useful in patients requiring a diuretic in whom it is desirable to avoid hyperuricemia.

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“…All currently availablediuretics frequently cause hyperuricemia and have the potential to precipitate an acute gouty ar thritis attack [2], Tierynafen [2,3-dichloro-4-(2 thienylcarbonyl)-phenoxy-acetic acid] is a new orally active diuretic agent with the unique property of having a pronounced uricosuric activity [3,4].…”

Section: Introductionmentioning

confidence: 99%

Renal Function during Therapy in Patients with Congestive Cardiac Failure

Smith

Clements

1979

Nephron

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14 patients with congestive heart failure requiring diuretic therapy were randomly assigned to treatment with ticrynafen (TCRN) 250 mg or hydrochlorothiazide (HCTZ) 50 mg once or twice daily. Both diuretics were effective and comparable in effecting a significant weight loss and increase in urinary sodium. The major difference between the two compounds was the marked fall in serum uric acid concentration and the increase in uric acid clearance occurring with ticrynafen. HCTZ caused an increase in serum uric acid and a fall in uric acid clearance. It is concluded that ticrynafen is a useful diuretic in the treatment of congestive heart failure and has the advantage of lowering serum uric acid rather than producing hyperuricemia.

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Clinical Study of Ticrynafen

Cited by 41 publications

References 2 publications

Comparative Effects of Ticrynafen and Hydrochlorothiazide on Blood Pressure, Renal Function, Serum Uric Acid and Electrolytes, and Body Fluid Spaces in Hypertensive Man

Comparative Effects of Ticrynafen and Hydrochlorothiazide on Blood Pressure, Renal Function, Serum Uric Acid and Electrolytes, and Body Fluid Spaces in Hypertensive Man

Ticrynafen, a uricosuric antihypertensive diuretic

Renal Function during Therapy in Patients with Congestive Cardiac Failure

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