Clinical study of Tongdu Shujin decoction in the treatment of ankylosing spondylitis with cold-dampness obstruction type: Study protocol for a randomized controlled trial

Wang, Zihua; Du, Mingrui; Li, Jigao; Shi, Dongliang; Wang, Hejun; Li, Huan; Guo, Hongtao

doi:10.1097/md.0000000000032852

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Oleh karena itu, usia bukan hanya sekadar angka, tetapi juga mencerminkan perjalanan biologis yang kompleks dengan dampak pada risiko penyakit. Tekanan darah, sebagai indikator vital dari kerja jantung dan kondisi pembuluh darah, juga berubah seiring bertambahnya usia (Griban et al, 2021;Mozolev et al, 2020;Wang et al, 2023). Beberapa studi menunjukkan bahwa tekanan darah cenderung meningkat seiring bertambahnya usia (Cruz-Aranda, 2019;Ishida et al, 2018).…”

Section: Pendahuluanunclassified

Pengaruh Usia terhadap Tingkat Tekanan Darah, serta Potensi Gangguan Kardiovaskular

Ina Ferawati,

Setiana

2023

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Cardiovascular disorders remain a major cause of global morbidity and mortality. The main aim of this study was to identify patterns of association between age and blood pressure and analyze their potential implications for the risk of cardiovascular disorders. The focus of blood pressure analysis is on systolic blood pressure (TDS). The research method involved collecting data on age, blood pressure, and disease history from 42 respondents in Hamlet VI Sonosewu, Kasihan, Bantul. All statistical analyses were performed using Ms. Excel. Statistical analysis is used to describe the pattern of relationships between these variables. The results of the correlation test showed that there is a relationship between age and blood pressure in the sample or population analyzed, which is confirmed by the ANOVA test (p-value: 0.002) and t-analysis test (p-value: 0.002), which produces a p-value < alpha or significance value (0.050). The potential for cardiovascular disorders is known from the results of the chi-square test, the Pearson chi-square statistical value (0,732)< the critical chi-square value (3,840). Based on these results, it can be concluded that in the context of this study. However, age cannot be the main factor determining blood pressure levels and is used as the only risk factor for cardiovascular disorders. Factors such as disease history and lifestyle can be considered as other factors that influence blood pressure levels and the risk of cardiovascular disorders. Blood pressure monitoring and appropriate preventive measures are essential, especially in the elderly age group

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Section: Pendahuluanunclassified

Pengaruh Usia terhadap Tingkat Tekanan Darah, serta Potensi Gangguan Kardiovaskular

Ina Ferawati,

Setiana

2023

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Evaluation of the efficacy of Tongdu Shujin Decoction combined with Adalimumab in the treatment of ankylosing spondylitis: A study protocol for a randomized controlled trial

Liu

Wang

et al. 2023

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Introduction Ankylosing spondylitis (AS) is a chronic inflammatory disease that typically affects the axial skeleton and entheses, and can lead to severe physical and psychological damage to patients. However, the current therapies have limitations.Methods and analysis Eighty-patients with AS will be recruited from the Rheumatology Department of the First Affiliated Hospital of the Henan University of Chinese Medicine. The participants will be randomly divided into the treatment and control groups at a 1:1 ratio. Subsequently, all subjects in the treatment group will receive 40 mg adalimumab administered subcutaneously every two weeks for 12 weeks, while patients in the control group will receive an extra dose of Tongdu Shujin Decoction (TDSJ) each day. The primary outcome will be determined by the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS) from baseline to 12 weeks. The secondary outcomes include changes of serum inflammatory cytokines, interleukin-6 (IL-6), interleukin-17 (IL-17), Tumor necrosis factor alpha (TNF-α), changes of anxious depression-related scales, Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9) as well as changes of McGill Pain Questionnaire (MPQ) and Fatigue Severity Scale (FSS) in patients from baseline to 12 weeks.Ethics and dissemination The ethics committee of the First Affiliated Hospital of Henan University of Chinese Medicine has approved the study on April 27, 2023 (2023HL-116-02). The Chinese national authorities issued approval on 15 May 2023. The outcome of the study will be disseminated via peer-reviewed publications and at congresses.Trial registration number Chinese Clinical Trial Registry. ChiCTR2300071418. Registered on 15th May 2023. https://www.chictr.org.cn/showproj.html?proj=196506

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Clinical study of Tongdu Shujin decoction in the treatment of ankylosing spondylitis with cold-dampness obstruction type: Study protocol for a randomized controlled trial

Cited by 2 publications

References 24 publications

Pengaruh Usia terhadap Tingkat Tekanan Darah, serta Potensi Gangguan Kardiovaskular

Pengaruh Usia terhadap Tingkat Tekanan Darah, serta Potensi Gangguan Kardiovaskular

Evaluation of the efficacy of Tongdu Shujin Decoction combined with Adalimumab in the treatment of ankylosing spondylitis: A study protocol for a randomized controlled trial

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