Clinical Study on 12-hydroxystearic Acid Organogel Ingestion

Hughes, N.E.; Rush, James W. E.; Marangoni, Alejandro G.

doi:10.1016/b978-0-9830791-1-8.50017-6

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…However, no oleogels have thus far been incorporated into commercial food products. Additionally, existing organogelators are either extremely expensive, unsuitable for use in foods, or possess a major flaw, such as the resulting oleogel having extreme shear sensitivity thus making their addition in food systems very challenging, if not impossible (Bot & Flö ter, 2011;Co & Marangoni, 2012;Hughes, Rush, & Marangoni, 2011). In this light, the discovery of EC as an organogelator was a step forward, as it is commercially available, inexpensive relative to many highly purified organogelators, and is also considered food grade or near-food grade, depending on the country or organization in question (Zetzl & Marangoni, 2014).…”

Section: Introductionmentioning

confidence: 99%

Microstructure of ethylcellulose oleogels and its relationship to mechanical properties

et al. 2014

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confidence: 99%

Microstructure of ethylcellulose oleogels and its relationship to mechanical properties

et al. 2014

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Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

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