Clinical Study on Safety of Cantharidin Sodium and Shenmai Injection Combined with Chemotherapy in Treating Patients with Breast Cancer Postoperatively

Wang, Lin; Huang, Xin-En; Cao, Jie

doi:10.7314/apjcp.2014.15.14.5597

Cited by 25 publications

(23 citation statements)

References 17 publications

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“…SMI had no significant impact on the ADR and PTX concentrations in the heart, liver and other tissues (Figure 3). In accordance with our results, SMI seems to be generally safe for clinical use [4,6,8,18] . Many studies have found that the synergistic effects of SMI or its main components, ginseng saponins, with chemotherapeutic agents were due to the influence on multiple cancer signaling pathways, such as NF-κB, JNK, MAPK, p53, among others [19,20] .…”

Section: Discussionsupporting

confidence: 92%

“…Currently, SMI is a famous Chinese patent-protected injection that has been widely applied in clinical practice for treating shock with qi and yin deficiency, coronary heart disease, viral myocarditis and tumors [4] . Various pharmacodynamic studies have demonstrated that SMI is effective in cancer interventions as an adjunct agent to chemotherapy [4,8,16] . Shenmai was found to be effective in treating cancer-related fatigue and the side effects induced by chemotherapy or radiotherapy [16] , which can be explained by the synergistic effect of Shenmai for qi and yin.…”

Section: Discussionmentioning

confidence: 99%

“…Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution eral malignancy types, including lung cancer [6] , liver cancer [7] , breast cancer [8] and gastric cancer [9] . However, most studies have focused on improving the immune function of cancer patients and decreasing the side effects of chemotherapy.…”

Section: Original Articlementioning

confidence: 99%

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Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

et al. 2016

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Shenmai injection (SMI) is a Chinese patent-protected injection, which was mainly made of Red Ginseng and Radix Ophiopogonis and widely used for treating coronary heart disease and tumors by boosting Qi and nourishing Yin. In this study we examined whether SMI could produce direct synergetic effects on the cytoxicity of adriamycin (ADR) and paclitaxel (PTX) in colorectal cancers in vivo and in vitro, and explored the underlying pharmacokinetic mechanisms. BALB/c nude mice with LoVo colon cancer xenografts were intraperitoneally injected with ADR (2 mg·kg -1 ·3d -1 ) or PTX (7.5 mg·kg -1 ·3d -1 ) with or without SMI (0.01 mL·g -1 ·d -1 ) for 13 d. Co-administration of SMI significantly enhanced the chemotherapeutic efficacy of ADR and PTX, whereas administration of SMI alone at the given dosage did not produce visible anti-cancer effects, The chemosensitizing action of SMI was associated with increased concentrations of ADR and PTX in the plasma and tumors. In Caco-2 and LoVo cells in vitro, co-treatment with SMI (2 μL/mL) significantly enhanced the cytotoxicity of ADR and PTX, and resulted in some favorable pharmacokinetic changes in the subcellular distribution of ADR and PTX. In addition, SMI-induced intracellular accumulation of ADR was closely correlated with the increased expression levels of P-glycoprotein in 4 colon cancer cell lines (r 2 =+0.8558). SMI enhances the anti-cancer effects of ADR and PTX in colon cancers in vivo and in vitro by improving the subcellular distributions of ADR and PTX.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

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Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

et al. 2016

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“…A clinical trial reported that cantharidin sodium, a semi-synthetic derivative of cantharidin, and Shenmai injection combined with chemotherapy in postoperative breast cancer patients significantly reduced the incidence of side effects (eg. leukopenia and gastrointestinal reactions) [26]. Norcantharidin, a demethylated analogue of cantharidin, has been suggested to induce cell apoptosis in human oral cancer cells via a mitochondria-mediated pathway [27].…”

Section: Introductionmentioning

confidence: 99%

Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways

Lee

Chen

et al. 2016

PLoS ONE

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Oral cancer is a subtype of head and neck cancer which represents 2.65% of all human malignancies. Most of oral cancer is histopathologically diagnosed as oral squamous cell carcinoma (OSCC). OSCC is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. How to prevention and treatment of OSCC is important and imperative. Here, we investigated the therapeutic effect and molecular mechanism of cantharidin, an active compound isolated from blister beetles, on OSCC in vitro. Results showed that cantharidin significantly decreased cell viability in human tongue squamous carcinoma-derived SAS, CAL-27, and SCC-4 cell lines. The further mechanistic studies were carried out in SAS cells. Cantharidin also significantly increased apoptosis-related signals, including caspase-9, caspase-7 and caspase-3 proteins. Besides, cantharidin decreased mitochondrial transmembrane potential (MMP) and induced cytochrome c and apoptosis inducing factor (AIF) release. Cantharidin also increased Bax, Bid, and Bak protein expressions and decreased Bcl-2 protein expression. Cantharidin could also increase the endoplasmic reticulum (ER) stress signals, including the expressions of phosphorylated eIF-2α and CHOP, but not Grp78 and Grp94. Furthermore, cantharidin reduced pro-caspase-12 protein expression. In signals of mitogen-activated protein kinases, cantharidin increased the phosphorylation of JNK, but not ERK and p38. Transfection of shRNA-JNK to OSCC cells effectively reversed the cantharidin-induced cell apoptotic signals, including the mitochondrial and ER stress-related signaling molecules. Taken together, these findings suggest that cantharidin induces apoptosis in OSCC cells via the JNK-regulated mitochondria and ER stress-related signaling pathways.

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“…Breast cancer remains a significant problem for women as it is one of the most common cause of tumor-related death world-wide as well as in China (Deng et al, 2013;Engin et al, 2013;Fouz et al, 2013;Liu et al, 2013;Sedighi et al, 2013;Zhu et al, 2013;Wang et al, 2014). When irinotecan is used for treating patients with MBC, several studies should be mentioned.…”

Section: Discussionmentioning

confidence: 99%

Irinotecan as a Palliative Therapy for Metastatic Breast Cancer Patients after Previous Chemotherapy

Lan¹,

Li²,

Lin³

2015

Asian Pacific Journal of Cancer Prevention

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Background: This analysis was conducted to evaluate the efficacy and safety of irinotecan based chemotherapy for treatment of patients with metastatic breast cancer (MBC) who experienced disease progression after one to three chemotherapy regimens, including at least one anthracycline-or taxane-based. Methods: Clinical studies were identified using a predefined search strategy. Pooled response rates (RR) to treatment were calculated. Results: As irinotecan based regimens, 5 clinical studies which including 217 patients with refractory MBC were considered eligible for inclusion, with irinotecan, cisplatin, capecitabine, or TS-1. Systemic analysis suggested that, in all patients, pooled RR was 48.8% (106/217) with irinotecan based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related deaths occurred. Conclusion: This systemic analysis suggests that irinotecan based regimens are beneficial and safe for treating patients with MBC after other chemotherapy.

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Clinical Study on Safety of Cantharidin Sodium and Shenmai Injection Combined with Chemotherapy in Treating Patients with Breast Cancer Postoperatively

Cited by 25 publications

References 17 publications

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution

Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways

Irinotecan as a Palliative Therapy for Metastatic Breast Cancer Patients after Previous Chemotherapy

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