Clinical study on the effect of decoction of Pavetta indica Linn. in treatment of Purishaja Krimi with special reference to Enterobius vermicularis infestation

Abstract

Pavetta indica Linn. (Family: Rubiaceae; Sanskrit name: Papata) is 2-5 m tall, shrub or small tree with opposite branches and grows in the Asia - Pacific region including Sri Lanka. Purishaja Krimi is one of the worm infestations described in Ayurveda. Enterobius vermicularis is among the most common of worms affecting children and adults. E. vermicularis is considered as one type of Purishaja Krimi. Sri Lankan traditional and ayurvedic physicians use P. indica to treat different ailments including Purishaja Krimi (E. vermicularis) infestations successfully. Since no scientific studies have been undertaken to study these effects so far, the present clinical study was carried out to evaluate the effect of P. indica in treatment of E. vermicularis infestation. Fifty patients between age of 5 and 12 years (Group A and B) and 50 patients between 13 and 65 years (Group C and D) with symptoms of E. vermicularis infestations such as itching in the anal region, impaired appetite, abdominal pain, eructation, diarrhea or constipation and presence of ova in stools were selected. Two decoction of the trail drug with different concentration was prepared. Group A and Group B were treated with 60 ml of decoction 1 and 60 ml of placebo respectively, twice daily for 14 days. Group C and Group D were treated with 120 ml of decoction 2 and 120 ml of placebo respectively, twice daily for 14 days. Groups A and C showed complete or partial reduction of symptoms, that is; itching in the anal region, impaired appetite, abdominal pain, eructation, diarrhea and also ova of E. vermicularis were absent in stools after treatment with P. indica. Decoction of P. indica can be recommended as an effective treatment for Purishaja Krimi (E. vermicularis infestation).

Evaluation of The In-Vitro Anthelmintic Activity of Leucas zeylanica Extracts on Earthworms

“…In Malaysia, leaves are used to cure wounds and taken as a sedative while traditional and Ayurvedic physicians in Sri Lanka employ L. zeylanica in the treatment of worm infections successfully. However, the effect it has as an anthelmintic has still not been scientifically proven (Ediriweera, 2014).…”

“…To counteract the limitation of the chemical drugs present on the market, a new approach is expected to be employed where natural medicinal plants are used as a treatment for this parasitic infection. On that account, the research was conducted to study the anthelminthic activity of L. zeylanica at different extraction solvents and concentrations in eluting worms based on the traditional Ayurvedic practice of this plant (Ediriweera, 2014). The success in proving its efficacy as an alternative treatment would be a stepping stone towards advancement in the development of a novel herbal medicinal plantbased product in the medical industry for helminthiasis.…”

Development of herbal skin care formulations from the hydro-alcoholic extract of Leucas zeylanica (L.) W.T.Aiton

“…Besides, the leaves of the plant are consumed as a vegetable [2]. The extracts prepared from L. zeylanica exhibited hepatoprotective effects [3] and were found to be highly effective against Enterobius vermicularis infections in adults [4]. Furthermore, the lipophilic extracts have displayed potent anti-inflammatory activities by inhibiting the two enzymes; 5-lipoxygenase and microsomal prostaglandin E 2 synthase-1 involved in the synthesis of pro-inflammatory eicosanoids.…”

Phytochemical and Potential Pharmacological Properties of Pavetta indica Linn

“…It is also reported that Sri Lankan traditional and ayurvedic specialists use Pavetta indica Linn to relieve different ailments, including Purishaja Krimi (E. vermicularis) infestations successfully. [6].…”