Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Gillet, Jean L; Jj, Guex; Allaert, F A; Avouac, Bernard; Léger, Philippe; Blaise, S.; Marchand, Angélique; Maillard, H.; Simon, M.; Amor, Cyrine Ben; Pasqualini, Marion

doi:10.1177/0268355519833523

Cited by 5 publications

(16 citation statements)

References 31 publications

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“…25,26 The European studies were conducted in the UK, 16,21 Germany, 22 Poland, 17 Italy, 18 and France. 20 One study was conducted in three countries (France, Germany, and the UK). 19 The majority of the included studies were clinical trials.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, seven studies compared different types of compression to determine which provides the best results. [16][17][18][19][20][21]25 Three of these articles also determined the cost and effectiveness of the different therapies. 16,18,21 The most common compression therapies were two-layer (elastic and inelastic) and four-layer compression therapies.…”

Section: Resultsmentioning

confidence: 99%

“…Seven articles compared different types of compression therapy (Tables 3 and 4). [16][17][18][19][20][21]25 Although the majority of them compared two types of therapy, 16,[18][19][20]25 two articles compared multiple types. 17,21 In addition, four of the articles also assessed the cost of the different therapies.…”

Section: • Evolution Of Vus By Type Of Compression Therapymentioning

confidence: 99%

“…17,21 In addition, four of the articles also assessed the cost of the different therapies. 16,18,20,21…”

Section: • Evolution Of Vus By Type Of Compression Therapymentioning

confidence: 99%

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Influence of Nutrition Status and Compression Therapy on Venous Ulcer Healing: A Systematic Review

García-Rodríguez

Rodríguez-Parrado

Seijo-Bestilleiro

et al. 2023

Adv Skin Wound Care

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OBJECTIVETo review the literature to determine whether compression therapies and nutrition status influence venous ulcer healing.DATA SOURCEA systematized bibliographic review was carried out by searching PubMed, Scopus, and Cochrane databases for studies published between 2015 and 2020, using descriptors in Spanish and English.STUDY SELECTIONAfter establishing the research question and applying the filters based on inclusion and exclusion criteria, 114 articles were found. After screening, 11 articles were selected for the review: 8 were identified in the literature search, and 3 were added from the bibliographic references of other studies.DATA EXTRACTIONThe authors developed a data extraction sheet that recorded the following variables: author, country, year of publication, level of evidence, research design, therapy type, initial ulcer size, active ulcer history, pain, healed wounds, wound reduction, therapy tolerance, nutrition assessment method, body mass index, and nutrition disorders.DATA SYNTHESISFour studies analyzed the relationship between nutrition status and venous ulcer healing, finding that these patients tend to have a high body mass index; a deficit of nutrients such as vitamin A, D, or zinc; and an excess of lipids and carbohydrates. Seven studies compared different types of compression to determine which provided the best results, with two- and four-layer therapy being the most commonly used. Variables such as small wound size and recent onset were associated with better prognosis.CONCLUSIONSIn terms of nutrition, the parameters analyzed are very limited. Although several studies show that two-layer therapy produces the greatest ulcer healing, there is not enough information to recommend one type of therapy over the other. Therefore, more clinical trials are needed to study broader nutrition parameters and compare the types of therapy under matched conditions to determine their influence on ulcer healing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: • Evolution Of Vus By Type Of Compression Therapymentioning

confidence: 99%

“…17,21 In addition, four of the articles also assessed the cost of the different therapies. 16,18,20,21…”

Section: • Evolution Of Vus By Type Of Compression Therapymentioning

confidence: 99%

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Influence of Nutrition Status and Compression Therapy on Venous Ulcer Healing: A Systematic Review

García-Rodríguez

Rodríguez-Parrado

Seijo-Bestilleiro

et al. 2023

Adv Skin Wound Care

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“…In the analysis (N = 88/95.6%), a complete healing rate of 48.9% and 24.4% was reported in the BIFLEX Kit versus PROFORE groups, respectively (ie, a superiority of 24.5%; P = 0.02). The authors concluded that the BIFLEX Kit represents a reasonable alternative therapy in the management of VLUs 25…”

Section: Results Of Scoping Review Of Clevdalmentioning

confidence: 99%

Compression for Lower Extremity Venous Disease and Lymphedema (CLEVDAL)

Ratliff

Yates

McNichol

et al. 2022

Journal of Wound, Ostomy &Amp; Continence Nursing

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The Wound, Ostomy and Continence Nurses (WOCN) Society charged a task force with updating the venous leg ulcer (VLU) algorithm to include the addition of lymphedema with the new title of “Compression for Lower Extremity Venous Disease and Lymphedema (CLEVDAL).” As part of the process, the task force was charged to develop consensus-based statements to serve as clinical guidance related to CLEVDAL. The 3-member task force assisted by a moderator completed a scoping literature review to identify recommendations supported by research to qualify as evidence-based and to identify areas where guidance is needed to provide CLEVDAL. Based on the findings of the scoping review, the WOCN Society convened a panel of experts to develop consensus statements to direct care for those with lower extremity venous disease and lymphedema. These consensus statements underwent a second round of content validation with a different panel of clinicians with expertise in venous disease and lymphedema management. This article reports on the scoping review and subsequent evidence-based statements, along with the generation and validation of consensus-based statements to assist clinical decision-making in the CLEVDAL algorithm.

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Compression bandages or stockings versus no compression for treating venous leg ulcers

Shi

Dumville

Cullum

et al. 2021

Cochrane Database of Systematic Reviews

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Background Leg ulcers are open skin wounds on the lower leg that can last weeks, months or even years. Most leg ulcers are the result of venous diseases. First‐line treatment options often include the use of compression bandages or stockings. Objectives To assess the effects of using compression bandages or stockings, compared with no compression, on the healing of venous leg ulcers in any setting and population. Search methods In June 2020 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE (including In‐Process & Other Non‐Indexed Citations), Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta‐analyses and health technology reports to identify additional studies. There were no restrictions by language, date of publication or study setting. Selection criteria We included randomised controlled trials that compared any types of compression bandages or stockings with no compression in participants with venous leg ulcers in any setting. Data collection and analysis At least two review authors independently assessed studies using predetermined inclusion criteria. We carried out data extraction, and risk‐of‐bias assessment using the Cochrane risk‐of‐bias tool. We assessed the certainty of the evidence according to GRADE methodology. Main results We included 14 studies (1391 participants) in the review. Most studies were small (median study sample size: 51 participants). Participants were recruited from acute‐care settings, outpatient settings and community settings, and a large proportion (65.9%; 917/1391) of participants had a confirmed history or clinical evidence of chronic venous disease, a confirmed cause of chronic venous insufficiency, or an ankle pressure/brachial pressure ratio of greater than 0.8 or 0.9. The average age of participants ranged from 58.0 to 76.5 years (median: 70.1 years). The average duration of their leg ulcers ranged from 9.0 weeks to 31.6 months (median: 22.0 months), and a large proportion of participants (64.8%; 901/1391) had ulcers with an area between 5 and 20 cm 2 . Studies had a median follow‐up of 12 weeks. Compression bandages or stockings applied included short‐stretch bandage, four‐layer compression bandage, and Unna's boot (a type of inelastic gauze bandage impregnated with zinc oxide), and comparator groups used included 'usual care', pharmacological treatment, a variety of dressings, and a variety of treatments where some participants received compression (but it was not the norm). Of the 14 included studies, 10 (71.4%) presented findings which we consider to be at high overall risk of bias. Primary outcomes There is moderat...

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Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial

Cited by 5 publications

References 31 publications

Influence of Nutrition Status and Compression Therapy on Venous Ulcer Healing: A Systematic Review

Influence of Nutrition Status and Compression Therapy on Venous Ulcer Healing: A Systematic Review

Compression for Lower Extremity Venous Disease and Lymphedema (CLEVDAL)

Compression bandages or stockings versus no compression for treating venous leg ulcers

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