Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia

Lin, Chieh‐Hsin; Huang, Chieh-Liang; Chang, Yue‐Cune; Chen, Po‐Wei; Lin, Chun-Yuan; Tsai, Guochuan E.; Lane, Hsien‐Yuan

doi:10.1016/j.schres.2013.02.009

Cited by 178 publications

(125 citation statements)

References 51 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Negative psychotic symptoms are considered reflective of the absence or reduction of normal brain function and contribute significantly to long-term morbidity and poor functional outcomes (Foussias et al, 2014). The neurodegenerative process present in schizophrenia may contribute to psychopathology development (especially negative symptoms) and the decline of cognition and poor social functioning (Lin et al, 2013;Szulc et al, 2012). Our study's findings imply that this neurodegenerative mechanism may also exist for meth users with psychotic experiences.…”

Section: Clinical Psychopathology and Cognitionmentioning

confidence: 65%

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Chen

Lin

Chen

et al. 2015

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Section: Clinical Psychopathology and Cognitionmentioning

confidence: 65%

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Chen

Lin

Chen

et al. 2015

Drug and Alcohol Dependence

View full text Add to dashboard Cite

“…Concerning cognitive function, previous studies have shown the importance of speed of processing in functional outcome 15,46,47,64. Lin et al reported that all cognitive domains of the MCCB were significantly correlated with the QLS score and among the cognitive domains, speed of processing was most strongly correlated with the QLS score 46. Lystad et al found that the MCCB speed of processing, along with attention, was most strongly related to and predictive of occupational functioning evaluated by the Work Behavior Inventory 47.…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, since the MCCB was developed, several studies have also reported the relationship between cognitive function measured by it and functional outcome 42–52. However, among those studies, few evaluated social function using the QLS 46,49…”

Section: Introductionmentioning

confidence: 99%

Relationship between social and cognitive functions in people with schizophrenia

Tominaga

Tomotake

Takeda

et al. 2018

NDT

View full text Add to dashboard Cite

PurposeThe purpose of the present study was to examine clinical factors related to social function in people with schizophrenia.Patients and methodsThe participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale.ResultsNeither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score.ConclusionThese results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.

show abstract

“…As described in the previous sections, both negative symptoms and impaired social cognition exert a deleterious impact on functional outcomes. The emerging evidence suggests that social cognition drives negative symptoms which, in turn, may play an indirect role, mediating the relationship between social cognition with functional outcomes [9,110,111]. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction with functional outcomes in schizophrenia [9,79,98].…”

Section: The Interplay Of Negative Symptoms With Deficits In Social Cmentioning

confidence: 99%

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Madeira¹,

Caldeira²,

Bajouco³

et al. 2016

IJCNMH

View full text Add to dashboard Cite

Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

show abstract

Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia

Cited by 178 publications

References 51 publications

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Relationship between social and cognitive functions in people with schizophrenia

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Contact Info

Product

Resources

About