Clinical Syndromes Associated with Ovarian Neoplasms: A Comprehensive Review<sup />

Shanbhogue, Alampady Krishna Prasad; Shanbhogue, Divya Krishna Prasad; Prasad, Srinivasa R.; Surabhi, Venkateswar R.; Fasih, Najla; Menias, Christine O.

doi:10.1148/rg.304095745

Cited by 98 publications

(74 citation statements)

References 59 publications

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“…The proportion of ovarian fibroma of all ovarian tumors is about 4% [6,7]. Fifteen to 40% of the ovarian fibromas are accompanied by isolated ascites and approximately 1% of the ovarian fibromas are associated with Meigs' syndrome [2,7,8]. Fibromas have a low malignant potential, and they are almost always benign.…”

Section: Discussionmentioning

confidence: 99%

A Case of Meigs’ Syndrome: The 18F-FDG PET/CT Findings

Lee

Kim

Yoo

et al. 2011

Nucl Med Mol Imaging

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Section: Discussionmentioning

confidence: 99%

A Case of Meigs’ Syndrome: The 18F-FDG PET/CT Findings

Lee

Kim

Yoo

et al. 2011

Nucl Med Mol Imaging

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“…[8] Nongestational choriocarcinoma are vascular solid tumors, commonly occurring in children and young adults and may manifest with isosexual precocity (approximately 50% of cases). [8] But these tumors present with elevated levels of total and β-hCG, which was absent in the present case of SST.…”

Section: Discussionmentioning

confidence: 99%

“…[8] Similarly, mature teratomas occur in young females and constitute about 50% of ovarian tumors in children. Virilization and hyper-estrogenism due to mature cystic teratomas have been reported, but predominantly in the postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing stromal tumor of the ovary presenting as precocious puberty: Unusual presentation of the rare neoplasm

Chaurasia¹,

Afroz²,

Maheshwari³

et al. 2014

Int J Med Public Health

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Sclerosing stromal tumor of the ovary presenting as precocious puberty: Unusual presentation of the rare neoplasm Sclerosing stromal tumor (SST) is a rare sex cord stromal neoplasm of the ovary. Precocious puberty resulting from this tumor is extremely rare. We report a case of SST of the ovary in a 7-year-old Indian girl, who presented with the complaints of excessive development of breasts, early menarche, growth of pubic hairs, accelerated growth and abdominal distension. On clinical examination, a large rightsided abdomino-pelvic mass was palpable. Magnetic resonance imaging revealed a large, heterogeneous, solid and cystic tumor in the right adenexal region, suggestive of an ovarian neoplasm. Hormonal profi le showed markedly elevated estradiol and low follicle stimulating hormone levels. Clinical diagnosis of precocious puberty with right-sided ovarian mass was thus concluded. Right-sided salpingo-oophorectomy was then performed. Histopathology showed features consistent with SST of the ovary. Postoperatively, signs and symptoms of precocity gradually regressed and her serum estradiol level came down to normal. Key words: Precocious, puberty, sclerosing stromal tumorCase Report INTRODUCTIONSclerosing stromal tumor (SST) is a rare benign sex cord stromal neoplasm of the ovary, which usually occurs in the second and third decades of life.[1] Patients with this tumor often present with the complaints of pelvic mass, pain, abdominal distention, and menstrual irregularities. Anovulation, virilization and infertility may be present in these patients because SST is associated occasionally with estrogen and rarely androgen secretion.[2] Precocious puberty resulting from this tumor is extremely rare. [3,4] This case is being reported due to unique and unusual presentation of rare SST of the ovary. To the best of our knowledge, this is the fi rst reported case of SST resulting in precocious puberty from India. CASE REPORTA 7-year-old Indian girl was presented by her mother to Gynecology Outpatient Department with the complaints of excessive development of her breasts for the last 1 year. She had attained menarche 8 months back. Her mother noticed growth of pubic hairs, accelerated body growth and abdominal distension for the last 4 months. Family history, antenatal, perinatal and developmental history was unremarkable. History of local trauma, sexual abuse, drug intake and any other systemic illness were absent. On clinical examination, a right-sided, large abdomino-pelvic mass was palpable. The mass was fi rm in consistency, immobile, measuring about 8 cm × 5 cm × 3 cm with well demarcated margins. Pelvic magnetic resonance imaging revealed a large, well-defi ned, heterogeneous solid and cystic mass measuring 8.5 cm × 5.5 cm × 4 cm in the right adenexal region [ Figure 1a]. Right ovary was not separately defi nable from the mass. The left ovary appeared normal. Patient's height was 127 cm and weight was 27 kg. She was Tanner stage IV for breast development and Tanner stage III for pubic hair. There were no signs of...

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“…kistadenom veya karsinom görülür. Herhangi bir tipe uymayan kitlelerde özellikle teratomlarda göz önünde bulundurulmalıdır [26]. Over tümörleri ile birlikte klinik sendromlar: En sık hormon salgılayan over tü-mörü seks kord stromal tümörlerdir.…”

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“…Bunlarda, I 131 Thyroid sintigrafisinde overde tutulum tanısaldır. Deği-şik paraneoplastik sendromlar epiteliyal over kanserlerinde görülebilir [26].…”

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Over Tümörlerinde Görüntüleme

Pekindil¹

2015

Trd Sem

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Over tümörleri patolojik olarak epitelial (seröz, müsinöz, endometrioid, clear cell, Brenner), germ hücreli (Teratom, disgerminom, endodermal sinüs tümörü, embriyoner hücreli karsinom, koriokarsinom), seks-kord stromal tümörler (Granülosa, fibrotekoma, sklerozan stromal tümör, Sertoli-Leydig hücreli tümör, steroid hücre ve diğer) ve metastatik tümörler olmak üzere 4 ana grupta irdelenebilir. Over kitlelerinin değerlendirilmesinde ultrasonografi (US), bilgisayarlı tomografi (BT) ve manyetik rezonans görüntüleme (MRG) kullanılmakta olup, burada tanısal etkinlikleri ve bulguları anlatılacaktır.Yaklaşım: Kadın pelvisinde bir kitle tespit edildiğinde 3 soruya cevap verilmesi gerekir: 1. Gerçekten kitle mi? yalancı ya da normal görüntü mü? En bilineni US'de rektum gazının teratom zannedilmesi, ya da gaz zannedilerek atlanmasıdır. Fonksiyonel over kistleri de patoloji zannedilebilir. 2. Kitle adneksiyal mi değil mi? Overlerin ayrı-intakt görülmesi over dışı kitle lehine olmakla birlikte, büyük kitlelerde özellikle postmenopoz küçük overin görülmesi sorun olabilir. Ovarial venin seyrinin bulunarak pelvik kitleye girdiğinin gösterilmesi de kitlenin over kaynaklı olduğunu belirlemede yardımcı (pedikül işareti) olabilir (Resim 1) [1,2]. Ayrıca subseröz-saplı myomlar, T2 A hipointens fibrom gibi solid over kitleleri ile karışabilece-ğinden ayrımda ara yüz damar işaretinin MRG ve Doppler US bakıda gösterilmesi myom lehinedir (Resim 2). 3. Adneksiyel ise malign ya da benign mi? Önce US sonra da gerekirse MRG ile değerlendirilir. Malign ise BT ya da MRG ile evrelemeye ilişkin sorulara yanıt aranır.Ultrasonografi: Pratikte adneksiyel kitle şüpheli olgulara öncelikle pelvik US yapılır. Transvajinal US'nin sınırlı görüş alanı ve derinlik gibi dezavantajları nedeniyle, adneksiyel kitlenin iç yapısını ve küçük kitleleri daha iyi saptamak gibi avantajlarına rağmen, pelvik US'ye tercih edilip edilmeyeceği konusu net değildir. Transvajinal US ile adneksiyel kitlenin duvar, septa ve iç yapısı ile ekojenitesine dayanan skorlama sistemi ile benign-malign over kitle ayrımında duyarlılık %100, özgüllük %83 olarak belirlenmiştir [3]. US ile morfolojik analiz yaparak over tümörlerinde maligniteyi belirlemede %85-97 duyarlılık, %56-95 öz-

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Clinical Syndromes Associated with Ovarian Neoplasms: A Comprehensive Review

Cited by 98 publications

References 59 publications

A Case of Meigs’ Syndrome: The 18F-FDG PET/CT Findings

A Case of Meigs’ Syndrome: The 18F-FDG PET/CT Findings

Sclerosing stromal tumor of the ovary presenting as precocious puberty: Unusual presentation of the rare neoplasm

Over Tümörlerinde Görüntüleme

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