Clinical systematic observation of Kangxin capsule curing vascular dementia of senile kidney deficiency and blood stagnation type

Liu, Xifei; Du, Jinyan; Cai, Jing; Liu, Xifeng; Xu, Gelin; Lin, Ang; Teng, Quincy

doi:10.1016/j.jep.2007.03.019

Cited by 18 publications

(22 citation statements)

References 4 publications

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“…Acupuncture has long been known to have a therapeutic effect on neurological diseases, including chronic pain, stroke as well as dementia [11]. It has been proved that acupuncture as an alternative therapy could enhance hippocampal LTP and improve memory-deficit symptoms [12].…”

Section: Introductionmentioning

confidence: 99%

Hippocampal cAMP/PKA/CREB is required for neuroprotective effect of acupuncture

Shi

Yang

et al. 2015

Physiology & Behavior

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Section: Introductionmentioning

confidence: 99%

Hippocampal cAMP/PKA/CREB is required for neuroprotective effect of acupuncture

Shi

Yang

et al. 2015

Physiology & Behavior

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“…Two herbs are included in BHD, namely Epimedium (Epimedium Davidii Franch, Yin Yang Huo) and Salvia Miltrorrhiza (Salvia Miltiorrhiza Bunge, Dan Shen). BHD has the efficacy of nourishing kidney and activating blood (Bu Shen Huo Xue), which is simplified from an impactful formula based on the Traditional Chinese Medicine theory that has been previously confirmed to have good efficacy in treating cognitive impairment, ischemic cerebral stroke and VaD (11). Although the formula has been proved to be effective in the clinical treatment of VaD, whether the simplified decoction BHD may improve cognitive deficits and the associated mechanism underlying its effects remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

et al. 2014

Molecular Medicine Reports

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Abstract. Cerebral hypoperfusion is a common feature of vascular dementia and has recently been recognized to contribute to the progression of cognitive decline. The present study aimed to investigate the effects of Bushen Huoxue decoction (BHD), a two-herb Chinese Medicine, on cognitive impairment in a rat model of cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). The results demonstrated that BHD significantly attenuated learning and spatial memory deficits in the Morris water maze test in a dose-dependent manner. Transmission electron microscopy observation revealed that the reduction of synapse density in hippocampal CA1 and cortex parietal isolated from rats with 2VO was partially restored by BHD treatment. In addition, the expression levels of a number of antioxidants, including superoxide dismutase, catalase (CAT), glutathine and glutathione peroxidase-1 (GPx-1) increased, whereas malondialdehyde decreased in the hippocampi of rats with 2VO following BHD treatment. Polymerase chain reaction and western blot analysis further confirmed that the GPx-1 and CAT expression increased in the BHD treatment group. In conclusion the results suggested that BHD has therapeutic potential to treat vascular dementia, which may be associated with synapse density and anti-oxidant activities in the hippocampus.

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“…According to Traditional Chinese Medicine (TCM), vascular dementia is considered as a result of insufficiency of kidney-yin and yin-blood [7]. It is believed that yin tonification or a therapeutic treatment that nourishes and replenishes yin of the body when it is deficient or weak can improve yin deficiency condition.…”

Section: Introductionmentioning

confidence: 99%

Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

Kaewkaen

Tong-Un

Wattanathorn

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Nowadays, the preventive strategy of vascular dementia, one of the challenge problems of elderly, has received attention due to the limitation of therapeutic efficacy. In this study, we aimed to determine the protective effect and possible mechanism of action of mulberry fruit extract on memory impairment and brain damage in animal model of vascular dementia. Male Wistar rats, weighing 300–350 g, were orally given mulberry extract at doses of 2, 10 and 50 mg/kg at a period of 7 days before and 21 days after the occlusion of right middle cerebral artery (Rt.MCAO). It was found that rats subjected to mulberry fruits plus Rt.MCAO showed the enhanced memory, the increased densities of neuron, cholinergic neuron, Bcl-2-immunopositive neuron together with the decreased oxidative stress in hippocampus. Taken all data together, the cognitive enhancing effect of mulberry fruit extract observed in this study might be partly associated with the increased cholinergic function and its neuroprotective effect in turn occurs partly via the decreased oxidative stress and apoptosis. Therefore, mulberry fruit is the potential natural cognitive enhancer and neuroprotectant. However, further researches are essential to elucidate the possible active ingredient.

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Clinical systematic observation of Kangxin capsule curing vascular dementia of senile kidney deficiency and blood stagnation type

Cited by 18 publications

References 4 publications

Hippocampal cAMP/PKA/CREB is required for neuroprotective effect of acupuncture

Hippocampal cAMP/PKA/CREB is required for neuroprotective effect of acupuncture

Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

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