Clinical traits of patients with major depressive disorder with comorbid borderline personality disorder based on propensity score matching

Tong, Ping; Bo, Ping; Shi, Yuanhong; Dong, Lei; Sun, Ting; Gao, Xia; Yang, Yang

doi:10.1002/da.23122

Cited by 3 publications

(1 citation statement)

References 33 publications

(40 reference statements)

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“…We used the 24-item Hamilton Rating Scale for Depression (HAMD) (Williams, 1988) and the 14-item Hamilton Rating Scale for Anxiety (HAMA) (Thompson, 2015) to assess the severity of depression and anxiety symptoms. Notably, we used the Chinese versions of the HAMD and HAMA, which have been documented to show great reliability and validity (Zheng et al, 1988) and have been widely applied in the Chinese population (Guo et al, 2015; Lai et al, 2021; Shen et al, 2020; Tong et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

Zhao

Zhu

et al. 2022

Psychol. Med.

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Background Vitamin D is engaged in various neural processes, with low vitamin D linked to depression and cognitive dysfunction. There are gender differences in depression and vitamin D level. However, the relationship between depression, gender, vitamin D, cognition, and brain function has yet to be determined. Methods One hundred and twenty-two patients with major depressive disorder (MDD) and 119 healthy controls underwent resting-state functional MRI and fractional amplitude of low-frequency fluctuations (fALFF) was calculated to assess brain function. Serum concentration of vitamin D (SCVD) and cognition (i.e. prospective memory and sustained attention) were also measured. Results We found a significant group-by-gender interaction effect on SCVD whereby MDD patients showed a reduction in SCVD relative to controls in females but not males. Concurrently, there was a female-specific association of SCVD with cognition and MDD-related fALFF alterations in widespread brain regions. Remarkably, MDD- and SCVD-related fALFF changes mediated the relation between SCVD and cognition in females. Conclusion Apart from providing insights into the neural mechanisms by which low vitamin D contributes to cognitive impairment in MDD in a gender-dependent manner, these findings might have clinical implications for assignment of female patients with MDD and cognitive dysfunction to adjuvant vitamin D supplementation therapy, which may ultimately advance a precision approach to personalized antidepressant choice.

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Section: Methodsmentioning

confidence: 99%

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

Zhao

Zhu

et al. 2022

Psychol. Med.

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The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial

Zhao,

Zhu,

Shen

et al. 2024

Psychol. Med.

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Background Growing evidence points to the pivotal role of vitamin D in the pathophysiology and treatment of major depressive disorder (MDD). However, there is a paucity of longitudinal research investigating the effects of vitamin D supplementation on the brain of MDD patients. Methods We conducted a double-blind randomized controlled trial in 46 MDD patients, who were randomly allocated into either VD (antidepressant medication + vitamin D supplementation) or NVD (antidepressant medication + placebos) groups. Data from diffusion tensor imaging, resting-state functional MRI, serum vitamin D concentration, and clinical symptoms were obtained at baseline and after an average of 7 months of intervention. Results Both VD and NVD groups showed significant improvement in depression and anxiety symptoms but with no significant differences between the two groups. However, a greater increase in serum vitamin D concentration was found to be associated with greater improvement in depression and anxiety symptoms in VD group. More importantly, neuroimaging data demonstrated disrupted white matter integrity of right inferior fronto-occipital fasciculus along with decreased functional connectivity between right frontoparietal and medial visual networks after intervention in NVD group, but no changes in VD group. Conclusions These findings suggest that vitamin D supplementation as adjunctive therapy to antidepressants may not only contribute to improvement in clinical symptoms but also help preserve brain structural and functional connectivity in MDD patients.

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Understanding chronic suicidality in borderline personality disorder through comparison with depressive disorder: a systematic review

Watt-McMahon

Mildred

King

et al. 2023

Clinical Psychologist

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Clinical traits of patients with major depressive disorder with comorbid borderline personality disorder based on propensity score matching

Cited by 3 publications

References 33 publications

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial

Understanding chronic suicidality in borderline personality disorder through comparison with depressive disorder: a systematic review

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