Clinical Translation of Molecular Imaging Probes

The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection

“…The general process of translating new nuclear medicine technologies has been explored in numerous reviews (81,82) and in the context of dedicated workshops, such as that organized by the National Institute of Biomedical Imaging and Bioengineering (National Institutes of Health) (83). The basic approach involves the approval of both government and institutional regulatory bodies, toxicology studies as required, radiochemical optimization, and first-in-humans studies usually initiated for dosimetry evaluation.…”