Clinical trial for the treatment of infertility due to poor oocyte quality

Zhang, Junyi; Zukin, V.; Alexandrova, Stoyana; Mazur, P.; Mykytenko, Dmytro; Liu, Hui; Dyachenko, Lada

doi:10.1186/isrctn13358803

Cited by 1 publication

(2 citation statements)

References 25 publications

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“…This is the antithesis of how scientific progress should be promoted and, thus, it was seriously criticized [ 26 , 60 ]. Recently, private fertility clinics have taken advantage of this status of legal void of MRTs in Europe, and two clinical trials have begun, one in Ukraine (led by Dr Zhang, [ 62 ]) and another one in Greece [ 63 ]. Both trials have reported child births during 2019 and more are expected in the near future.…”

Section: Resultsmentioning

confidence: 99%

“…Both trials have reported child births during 2019 and more are expected in the near future. The lack of a therapeutic aim is the most alarming point, since these two trials are being employed to improve the fertility in elderly women with failure in several in vitro fertilization cycles [ 62 , 63 ]. However, there is not enough scientific evidence supporting the role of mitochondrion in infertility [ 23 ] of uncertain etiology.…”

Section: Resultsmentioning

confidence: 99%

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Mitochondrial DNA Replacement Techniques to Prevent Human Mitochondrial Diseases

Sendra

García-Mares

Herrero

et al. 2021

IJMS

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Background: Mitochondrial DNA (mtDNA) diseases are a group of maternally inherited genetic disorders caused by a lack of energy production. Currently, mtDNA diseases have a poor prognosis and no known cure. The chance to have unaffected offspring with a genetic link is important for the affected families, and mitochondrial replacement techniques (MRTs) allow them to do so. MRTs consist of transferring the nuclear DNA from an oocyte with pathogenic mtDNA to an enucleated donor oocyte without pathogenic mtDNA. This paper aims to determine the efficacy, associated risks, and main ethical and legal issues related to MRTs. Methods: A bibliographic review was performed on the MEDLINE and Web of Science databases, along with searches for related clinical trials and news. Results: A total of 48 publications were included for review. Five MRT procedures were identified and their efficacy was compared. Three main risks associated with MRTs were discussed, and the ethical views and legal position of MRTs were reviewed. Conclusions: MRTs are an effective approach to minimizing the risk of transmitting mtDNA diseases, but they do not remove it entirely. Global legal regulation of MRTs is required.

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