Clinical Trial of a Feline Pheromone Analogue for Feline Urine Marking.

Ogata, Niwako; Takeuchi, Yukari

doi:10.1292/jvms.63.157

Cited by 35 publications

(40 citation statements)

References 7 publications

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“…The home environment of the feline participants varied both within and between studies. All cats were studied in their home environment, this was usually the household although, Ogata and Takeuchi [5] reported that two cats from their study population spent a proportion of time in a cage. In all reports the cats were managed either as indoor only cats or indoor cats with some degree of outdoor access.…”

Section: Types Of Participantsmentioning

confidence: 99%

“…The tendency to offer behavioural advice differed between studies. Frank et al [2]; Landsberg and Wilson [33]; Mills and Mills [6]; Ogata and Takeuchi [5] stated that no specific behavioural advice was offered whereas, Hart et al [21]; King et al [19]; Pryor et al [18] advised owners to employ basic environmental management such as ensuring urine marks were cleaned with an appropriate enzyme based cleaner and keeping litter boxes clean.…”

Section: Types Of Participantsmentioning

confidence: 99%

“…Four studies were included in the analysis that evaluated the use of the synthetic feline facial pheromone F3 over a four week treatment period [2,5,6,32]. Heterogeneity was not evidenced between studies (Cochran Q test P.0.10).…”

Section: Primary Outcome: Analysis By Intervention Type: Synthetic Fementioning

confidence: 99%

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The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

Ellis¹,

Redgate

Zinchenko

et al. 2015

Applied Animal Behaviour Science

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Feline urine spraying inside the home is a common problem behaviour that owners seek advice for from veterinarians. Individual trials relating to a variety of interventions produce variable results, and to date, no consensus on the value of different treatments has emerged. This study therefore aimed to meta-analyse, current data from appropriate published clinical trials that evaluate treatments for feline urine spraying. Inclusion and exclusion criteria for study selection were predefined and methodological quality was assessed by two independent reviewers. Ten studies in nine publications that either evaluated pharmacotherapy or pheromonatherapy (the use of a synthetic analogue of the F3 facial fraction in the cat) were suitable for analysis. There was a significant (P,0.001) association between the use of any intervention and the number of cats that ceased or reduced urine spraying by at least 90%. Analysis by intervention type indicated that fluoxetine, clomipramine and pheromonatherapy may each assist in managing urine spraying beyond a placebo based intervention. This is the first time meta-analytical techniques have been used and reported to evaluate the efficacy of interventions used in veterinary behavioural medicine, and it has established confidence in the value of both conventional treatments (pharmacotherapy) and a more recently developed treatment modality (pheromonatherapy) as an adjunct to the management of this problem. It is suggested that future research into treatment efficacy for this problem uses the benchmark standard of randomised, controlled trials lasting for at least 8 weeks, with the outcome criteria of cessation of feline urine spraying or reduction by at least 90%.

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Section: Types Of Participantsmentioning

confidence: 99%

Section: Types Of Participantsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

Ellis¹,

Redgate

Zinchenko

et al. 2015

Applied Animal Behaviour Science

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“…Medications such as amitriptyline and buspirone have variable success rates and may have undesirable side effects such as sedation or hepatotoxicity (Lindell, Erb, & Houpt, 1997;Overall, 1992). Feliway TM , a derivative of Feline Facial Pheromone (Ceva Animal Health, Lenexa, KS), has been shown to reduce urine marking, aggression, and fear in domestic cats when administered in spray and diffuser forms (Gunn-Moore & Cameron, 2004;Mills & Mills, 2001;Ogata & Takeuchi, 2001). However, these studies have had variable success rates and sprays require daily reapplication (GunnMoore & Cameron, 2004;Mills, Redgate, & Landsberg, 2011).…”

Section: Introductionmentioning

confidence: 99%

Maternal-Neonatal Pheromone/Interomone Added to Cat Litter Improves Litter Box Use and Reduces Aggression in Pair-Housed Cats

McGlone

García

Thompson³

et al. 2018

Journal of Applied Animal Welfare Science

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Introducing a new cat into a household with one or more resident cats can be a significant source of stress for the cats involved. These studies sought to determine if rabbit maternal-neonatal pheromone (2-methyl-2-butenal [2M2B]) in litter impacted cat social behaviors and litter box use. Study 1 determined that cats preferred to eliminate in litter containing 2M2B; other semiochemicals tested did not change litter box use. Cats prone to aggression were identified in an intermediate pilot study, and eight pairs of these cats were selected for Study 2. In Study 2, cat pairs were provided litter containing either vehicle or 2M2B for 24 hours. Cats experiencing control litter displayed more aggression during the first 6 hours (p < .01) and spent more time using the litter box 12 hours and 18 hours after pairing compared with cats experiencing litter with 2M2B (p = .02). These results suggest 2M2B-infused cat litter may act as an interomone in cats housed domestically to prevent initial occurrences of aggression and may improve cat welfare in multicat households.

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“…1e3 Although most cat owners believe their cats get on well with people, human directed aggression is a common problem. 4e6 Scientific reports suggest that aggression towards either people or among cats accounts for between 12 and 47% of the total behavioural problems reported by owners, 7e11 although the concept of aggression in cats is often not well defined, for example, some authors (eg, Overall 12 ) consider urine spraying to be a passive form of aggression and the finding that the response to certain treatments for urine spraying is affected by overt physical aggression, 13 may support this idea. However, in common parlance aggression is often taken to include elements of threat and acts resulting in harm.…”

mentioning

confidence: 99%

Human directed aggression in Brazilian domestic cats: Owner reported prevalence, contexts and risk factors

Ramos

Mills

2009

Journal of Feline Medicine and Surgery

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Aggression by cats towards humans is a serious behavioural, welfare and public health problem, although owners may believe it is an inevitable part of cat ownership. There has been little scientific investigation of the risk factors associated with this problem. One hundred and seven owners in the Sao Paulo region of Brazil, took part in a survey aimed at investigating the perceived prevalence of the problem, defining the most common contexts of human directed aggression and identifying associated potential risk factors. Human directed aggression occurred in 49.5% of cats and was most commonly associated with situations involving petting and play, followed by protection of a resource, when startled, when observing an unfamiliar animal and least commonly when unfamiliar people were present. Pedigree status, neuter status, a history of early trauma, sensitivity to being stroked, the absence of other cats in the home, relationship with other animals, level of background activity at home, access to the outside and tendency to be alone (meaning tendency to staying far from the family members) were all associated with an increased risk in one or more context. However, sex, age, age when acquired, source of pet, attachment to a specific household member, type of domestic accommodation, relationship with another cat if present and contact with other animals did not appear to increase the risk. The results suggest sensitivity to being stroked and background levels of stress in the home are the most pervasive risk factors, and future research should aim to investigate these factors further. These data are of relevance when advising owners about the risk and development of this problem.

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Clinical Trial of a Feline Pheromone Analogue for Feline Urine Marking.

Cited by 35 publications

References 7 publications

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

Maternal-Neonatal Pheromone/Interomone Added to Cat Litter Improves Litter Box Use and Reduces Aggression in Pair-Housed Cats

Human directed aggression in Brazilian domestic cats: Owner reported prevalence, contexts and risk factors

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