Clinical Trial of Chronic Implantation of Suprachoroidal-Transretinal Stimulation System for Retinal Prosthesis

doi:10.18494/sam.2012.822

Cited by 1 publication

(1 citation statement)

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“…Retinal neuroprostheses aim to provide artificial vision to those suffering from profound vision loss and blindness due to inherited photoreceptor dystrophies such as retinitis pigmentosa [1] by electrically stimulating the residual retinal network to elicit visual percepts. While numerous clinical trials have shown that visual percepts can be elicited [2][3][4][5], and partial visual function such as object detection, localisation, or navigation can be restored by activating neurons in the retina [6][7][8][9][10][11][12][13][14][15][16][17], most patients have little benefit in terms of visual quality [18].Though there are potentially multiple factors including limited 7 Author to whom any correspondence should be addressed. spatial [19,20] and temporal resolution [21,22] which could be attributed to this suboptimal performance, it is argued that the indiscriminate activation of functionally-different retinal ganglion cells (RGCs) plays an important role in limiting the vision.…”

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confidence: 99%

Neural activity of functionally different retinal ganglion cells can be robustly modulated by high-rate electrical pulse trains

et al. 2020

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Objective. This study focused on characterising the response of four major functionally-different retinal ganglion cells (RGCs) to a high frequency stimulus (HFS) paradigm. Approach. We used in vitro patch clamp experiments to assess the viability of evoking a differential response between different RGC types—OFF-Sustained, OFF-Transient, ON-Sustained and ON-Transient—under a wide range of HFS and stimulation amplitude combinations. Main results. Of the four types, we found that the OFF-Sustained, OFF-Transient and ON-Transient RGCs could be differentially activated at various frequency and amplitude combinations, in particular, OFF-Sustained cells can be differentially targeted between 20–100 µA at all frequencies, OFF-Transient cells between 150–240 µA at 1 kHz and ON-Transient between 180–240 µA and 4–6 kHz. We further found that this differential activation held true when the stimulus duration was reduced from 300 ms to 50 ms. Finally, we found that the cell spiking response was not primarily dependent on total charge contained in the pulse train or current amplitude alone, but a combination of amplitude and frequency. Significance. These results indicate that HFS may be a promising method to target functionally-distinct neural pathways in the retina in an effort to improve the vision quality with retinal prostheses.

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