Clinical Trial of Induction of Labor versus Expectant Management in Twin Pregnancy

Suzuki, Shunji; Otsubo, Yasuo; Sawa, Rintaro; Yoneyama, Yoshio; Araki, Tsutomu

doi:10.1159/000010207

Cited by 69 publications

(50 citation statements)

References 12 publications

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“…Primary studies,15 16 29 39 62 systematic reviews,13 and guideline bodies9 63 have been limited in their interpretation of evidence on the timing of delivery in twin pregnancies because of paucity of data and inadequate methods. Firstly, they compared the risks of stillbirth in twin pregnancies at various gestational weeks with those at, or near, term, without considering the inherent longitudinal design with women repeatedly observed during the pregnancy 64.…”

Section: Discussionmentioning

confidence: 99%

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

Cheong-See

Schuit

Arroyo-Manzano

et al. 2016

BMJ

194

150

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Objective To determine the risks of stillbirth and neonatal complications by gestational age in uncomplicated monochorionic and dichorionic twin pregnancies.Design Systematic review and meta-analysis.Data sources Medline, Embase, and Cochrane databases (until December 2015). Review methods Databases were searched without language restrictions for studies of women with uncomplicated twin pregnancies that reported rates of stillbirth and neonatal outcomes at various gestational ages. Pregnancies with unclear chorionicity, monoamnionicity, and twin to twin transfusion syndrome were excluded. Meta-analyses of observational studies and cohorts nested within randomised studies were undertaken. Prospective risk of stillbirth was computed for each study at a given week of gestation and compared with the risk of neonatal death among deliveries in the same week. Gestational age specific differences in risk were estimated for stillbirths and neonatal deaths in monochorionic and dichorionic twin pregnancies after 34 weeks’ gestation.Results 32 studies (29 685 dichorionic, 5486 monochorionic pregnancies) were included. In dichorionic twin pregnancies beyond 34 weeks (15 studies, 17 830 pregnancies), the prospective weekly risk of stillbirths from expectant management and the risk of neonatal death from delivery were balanced at 37 weeks’ gestation (risk difference 1.2/1000, 95% confidence interval −1.3 to 3.6; I2=0%). Delay in delivery by a week (to 38 weeks) led to an additional 8.8 perinatal deaths per 1000 pregnancies (95% confidence interval 3.6 to 14.0/1000; I2=0%) compared with the previous week. In monochorionic pregnancies beyond 34 weeks (13 studies, 2149 pregnancies), there was a trend towards an increase in stillbirths compared with neonatal deaths after 36 weeks, with an additional 2.5 per 1000 perinatal deaths, which was not significant (−12.4 to 17.4/1000; I2=0%). The rates of neonatal morbidity showed a consistent reduction with increasing gestational age in monochorionic and dichorionic pregnancies, and admission to the neonatal intensive care unit was the commonest neonatal complication. The actual risk of stillbirth near term might be higher than reported estimates because of the policy of planned delivery in twin pregnancies.Conclusions To minimise perinatal deaths, in uncomplicated dichorionic twin pregnancies delivery should be considered at 37 weeks’ gestation; in monochorionic pregnancies delivery should be considered at 36 weeks.Systematic review registration PROSPERO CRD42014007538.

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Section: Discussionmentioning

confidence: 99%

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

Cheong-See

Schuit

Arroyo-Manzano

et al. 2016

BMJ

194

150

View full text Add to dashboard Cite

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“…Induction has also been carried out for medical reasons such as diabetes mellitus and hypertensive disorders [9][10][11][12][13][14]. In our context, induction may follow the request made by the woman, her husband or family.…”

Section: R E Mbu Et Al / Open Journal Of Obstetrics and Gynecologymentioning

confidence: 99%

“…In our daily practice, the decision to induce twin gestations has not been accepted by many and a review of the relevant literature does not give us sufficient data to support those who are for or those who are against. Up to date, studies on the subject have mitigating conclusions [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. However induction in highly selected cases of twin gestations may not be specifically disadvantageous to mothers nor their fetuses.…”

Section: R E Mbu Et Al / Open Journal Of Obstetrics and Gynecologymentioning

confidence: 99%

Twin gestation: Is induction of labor possible in highly selected cases?

Mbu¹,

Fouedjio²,

Fouelifack³

et al. 2012

OJOG

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Induction of labor has been in practice for several decades but the decision to induce labor in multifetal gestations has not been accepted by many practitioners in contemporary obstetrics. The aim of this study was to compare maternal and fetal outcomes among women with uncomplicated twin gestations who were induced at term and those who were not. It was a cross-sectional analytic study that lasted ten years, (1 st January 2000 to 31 st December 2009 inclusive) at the maternity of the central hospital, Yaounde, Cameroon. 158 women were enrolled, 79 were induced and 79 went into labor spontaneously. Maternal and fetal outcomes, duration of labor, the prevalence of caesarean section were compared in the two groups. The average age of the women in the groups was 26, 75 ± 3.65 years (range 15 -41 years). For those who were induced, indication was premature rupture of membranes in 44 (56%) of cases. The characteristics of induced and none induced women were similar, except for the number of antenatal consultations (P ≤ 0.001). There was a significant difference in the duration of labor in the two groups (6 hrs versus 9, 75 hrs; P ≤ 0.001). The overall rate of vaginal delivery in the two groups was 87, 97% (n = 139), 88.87% in the group that was induced versus 86.07% in the group that labor was spontaneous (OR 1, 22; 95% IC 0, 51-2, 92; P ≤ 0.90). With respect to primary outcomes, there were no statistically significant differences between the group that labor was induced and that which labor was spontaneous. The prevalence of caesarean delivery was similar in the two groups (10%, 12% vs 13%, 92%; OR 0%, 7%; 95% IC 0, 27-1, 85; P ≤ 0.50). The main indications for caesarean section were acute fetal distress and failed induction. The first and fifth minute APGAR scores less than 7 in the first twins delivered in the two groups were similar. The 312 children delivered in both arms did not show any complications at birth. However, there were 3 neonatal deaths (1 vs 2). There were no cases of uterine rupture or maternal deaths among the 156 women. Induction of labor may be proposed to women with uncomplicated term twin gestations with specific indications. Induction in these highly selected cases does not impute any additional risks but close monitoring of labor is very necessary.

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“…Datos poblacionales muestran un aumento de la morbimortalidad perinatal que comienza a las 38-39 semanas, por lo que resultaría prudente considerar la interrupción del embarazo antes de esta edad gestacional (81). Los revisores de la Cochrane Library analizaron la evidencia para sustentar la interrupción de los embarazos gemelares desde las 37 semanas de gestación y concluyeron que el estudio disponible es demasiado pequeño para detectar las mediciones de resultados de interés, consecuentemente hay datos insuficientes para apoyar la práctica de interrupción electiva desde las 37 semanas en adelante en un embarazo gemelar sin complicaciones (82,83). Sin embargo, en la práctica clínica habitual se tiende a interrumpir electivamente los embarazos gemelares no complicados entre las 37 y 38 semanas.…”

Section: Momento De Interrupción Y Manejo Intrapartounclassified

Pautas De Manejo Clínico De Embarazos Gemelares

Becker

2009

Rev. chil. obstet. ginecol.

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RESUMENEl embarazo gemelar conlleva un elevado riesgo de morbilidad y mortalidad perinatal. Teniendo el control prenatal una reconocida utilidad en disminuir la morbimortalidad perinatal, decidimos elaborar pautas de manejo clínico, basadas en evidencia, que orienten el seguimiento prenatal de embarazos gemelares. Realizamos una revisión de las publicaciones recientes, guías clínicas y textos clásicos de obstetricia obteniendo la información necesaria. Presentamos un listado de las recomendaciones y la calidad de evidencia que las sustenta, respecto de seis ítems: a. Reproducción asistida; b. Diagnóstico de embarazo gemelar; c. Manejo general del embarazo gemelar; d. Parto prematuro; e. Complicaciones específicas de embarazos gemelares; y f. Momento de interrupción y manejo del trabajo de parto. PALABRAS CLAVE: Embarazo múltiple, embarazo gemelar, guías clínicas SUMMARYMultiple pregnancy has high risk of perinatal morbidity and mortality. Since antenatal care has been demonstrated as a useful tool in reducing perinatal risk, we decided to elaborate evidence based clinical guidelines, to facilitate antenatal care of women carrying multiple pregnancies. We reviewed recent publications, clinical guidelines and text books to obtain necessary information. Here we present a list of recommendations, and the quality of supporting evidence, about six items: a. Assisted reproduction; b. Diagnosis of multiple pregnancy; c. General care of multiple pregnancy; d. Preterm Labor; e. Specific complications of multiple pregnancy; f. Timing of delivery and labor management. KEY WORDS: Multiple pregnancy, twin pregnancy, guidelines INTRODUCCIÓNLa incidencia de embarazos múltiples ha aumentado dramáticamente en las últimas décadas en los países desarrollados, desde 1 por 100 nacidos vivos a 1 por 70 nacidos vivos, con un aumento de un 40% en la tasa de embarazos gemelares y un aumento de 3 a 4 veces en embarazos múlti-ples de alto orden. Este aumento en el número de embarazos múltiples es atribuible en mayor parte a la utilización de técnicas de reproducción asistida, pero también se explica por un aumento en la edad materna, ya que existe asociación entre la edad materna y la tasa de gestaciones múltiples concebidas espontáneamente (1).El embarazo múltiple es un embarazo de alto riesgo fetal, pues tiene, entre otros problemas, mayor incidencia de prematurez, restricción del crecimiento fetal, malformaciones congénitas y muerte fetal in útero comparado con las gestaciones úni-cas. Existen además, complicaciones propias del embarazo gemelar como: crecimiento discordante, muerte in útero de alguno de los gemelos, síndrome de transfusión feto-fetal, gemelos monoamnióticos

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Clinical Trial of Induction of Labor versus Expectant Management in Twin Pregnancy

Cited by 69 publications

References 12 publications

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis

Twin gestation: Is induction of labor possible in highly selected cases?

Pautas De Manejo Clínico De Embarazos Gemelares

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