Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee

Dixon, A. St. J.; Jacoby, R K; Berry, H; Hamilton, E. B. D.

doi:10.1185/03007998809114237

Cited by 143 publications

(49 citation statements)

References 17 publications

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“…Sodium hyaluronate has been widely used for patients with various joint disorders. 24,25 However, injection of sodium hyaluronate into the TMJ cavity as well as drug administration and physiotherapy after pumping manipulation treatment may have biased the study results.…”

Section: Discussionmentioning

confidence: 99%

An image-guided technique for puncture of the superior temporomandibular joint cavity: clinical comparison with the conventional puncture technique

Matsumoto

Bjørnland

Kai

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. The objective of this study was to compare an image-guided puncture technique (IGPT) with conventional puncture technique (CPT) with respect to accuracy of needle entry, maximal mouth opening, and pain in pumping manipulation treatment of internal derangement of the temporomandibular joint (TMJ). Study design. The subjects comprised 178 patients with internal derangement of the TMJ with closed lock. Treatment was provided using CPT in 102 cases and IGPT in 76 cases. Three variables, number of repunctures, maximal mouth opening distance, and pain threshold according to a visual analogue scale, were measured and compared between IGPT and CPT groups. Results. Access to the superior joint cavity was achieved without correcting the puncture point in 97% of patients who underwent IGPT and 82% of patients in the CPT group. Significant differences were seen in 1-week maximal mouth opening and pain threshold between IGPT and CPT groups (P Ͻ .05 each) and resetting of the puncture point was significantly less frequent using IGPT compared with CPT (P Ͻ .05).

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Section: Discussionmentioning

confidence: 99%

An image-guided technique for puncture of the superior temporomandibular joint cavity: clinical comparison with the conventional puncture technique

Matsumoto

Bjørnland

Kai

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…12,16,28,30,31,37 Sixteen trials reported that the outcome observer was blinded to the intervention. 12,16,18,20,22,23,[26][27][28][29][30][31][32][33]35,37 Two trials did not present any usable quantitative information. 30,35 Therefore, only 22 trials were included in the analysis of at least 1 of the predefined efficacy end points (Fig.…”

Section: Trial Qualitymentioning

confidence: 99%

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis

Arrich

Piribauer²,

Mad³

et al. 2005

Canadian Medical Association Journal

281

182

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Review SynthèseO steoarthritis affects about 10% of the population over 55 years of age. Of those, one-quarter are severely disabled.1 The condition is characterized by degeneration of the articular cartilage and subsequent subchondral bone changes. The underlying mechanisms remain unknown, but the glycosaminoglycan-proteoglycan matrix may play a major role. 2 Hyaluronic acid, a glycosaminoglycan, is widely used for the treatment of osteoarthritis of the knee. A survey of 2 general practices in the United Kingdom showed that about 15% of patients with osteoarthritis received intraarticular treatment with glucosamine sulfates. 3 The costs of such treatment are significant. At present, 1 syringe of hyaluronic acid costs at least Can$130 (US$110). The treatment of knee osteoarthritis is covered by the US Medicare program but not by provincial formularies in Canada. In Austria (which has 8 million inhabitants) more than 10 million euros (approximately US$12 million or Can$15 million) is spent by social insurance programs annually for hyaluronic acid preparations (excluding the cost of application).Hyaluronic acid has beneficial effects in vitro. 4 Because of its viscoelastic quality, it may replace synovial fluid. Furthermore, it may reduce the perception of pain. Beneficial molecular and cellular effects have also been reported. 2,4Hyaluronic acid is frequently applied by intra-articular injection, but the evidence concerning its clinical relevance is conflicting. The European League against Rheumatism (EULAR) recommends the intra-articular application of hyaluronic acid as "category 2" evidence (at least 1 controlled study without randomization). 5 The American College of Rheumatology recommends intra-articular hyaluron therapy for patients with no response to nonpharmacologic therapy and simple analgesics. 6 In contrast, other specialists have concluded that "hyaluronate sodium is not efficacious" in the treatment of osteoarthritis. 7 The first state-of-the-art systematic review and meta-analysis was published recently, 8 and its authors concluded "that intra-articular hyaluronic acid, at best, has a small effect."We performed a systematic review and meta-analysis of Abstract Background: Osteoarthritis of the knee affects up to 10% of the elderly population. The condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a systematic review and meta-analysis of randomized controlled trials to assess the effectiveness of this treatment. Methods: We searched MEDLINE, EMBASE, CINAHL, BIOSISand the Cochrane Controlled Trial Register from inception until April 2004 using a combination of search terms for knee osteoarthritis and hyaluronic acid and a filter for randomized controlled trials. We extracted data on pain at rest, pain during or immediately after movement, joint function and adverse events. Results: Twenty-two trials that reported usable quantitative information on any of the predefined end points were identified and included in the systematic review. Even though pain at res...

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“…Many randomized controlled studies have demonstrated a longer-term effect in pain control with HA injections compared with corticosteroids [31] and placebo [32,33]. Hyaluronic acid has approximately a 1% incidence of side effects per injection.…”

Section: Discussionmentioning

confidence: 99%

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Hussain¹,

Rather²,

Qayoom³

2014

J Trauma Treat

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Clinical trial of intra-articular injection of sodium hyaluronate in patients with osteoarthritis of the knee

Cited by 143 publications

References 17 publications

An image-guided technique for puncture of the superior temporomandibular joint cavity: clinical comparison with the conventional puncture technique

An image-guided technique for puncture of the superior temporomandibular joint cavity: clinical comparison with the conventional puncture technique

Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

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