Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients

Zanforlini, Bruno Micael; Ceolin, Chiara; Trevisan, Caterina; Alessi, Agnese; Seccia, Daniele Michele; Noale, Marianna; Maggi, Stefania; Guarnieri, Gabriella; Vianello, Andrea; Sergi, Giuseppe

doi:10.1007/s40520-021-01921-z

Cited by 21 publications

(11 citation statements)

References 31 publications

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“…As shown in Figure 1 , among 2501 records initially screened, 31 were retrieved as full-texts: of them, 17 papers [ 17 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ] were included in the systematic review with 15 contributing to the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Veronese

Pizzol²,

Smith

et al. 2022

Nutrients

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23rd November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present. In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.

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Section: Resultsmentioning

confidence: 99%

“… Forrest plot of the effect of magnesium versus placebo on serum C-reactive protein [ 17 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 38 , 39 ]. …”

Section: Figurementioning

confidence: 99%

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Veronese

Pizzol²,

Smith

et al. 2022

Nutrients

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“…However, significant between-group differences only appeared in bodily pain. Concerning the relationship between quality of life and supplement intake, the current literature is ambiguous and depends on the active principle analyzed [ 73 , 74 , 75 , 76 ]. In this regard, RT is a major predictor for improving the quality of life in older adults [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Microfiltered Seawater Intake and Variable Resistance Training on Strength, Bone Health, Body Composition, and Quality of Life in Older Women: A 32-Week Randomized, Double-Blinded, Placebo-Controlled Trial

Juesas

Gargallo

Gené-Morales

et al. 2023

IJERPH

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The aim was to explore the effects of a 32-week resistance training (RT) intervention with elastic bands with or without microfiltered seawater (SW) supplementation on isokinetic strength, bone mineral density (BMD), body composition, and subjective quality of life in postmenopausal women. Ninety-three untrained women (age: 70.00 ± 6.26 years; body mass index: 22.05 ± 3.20 kg/m2; body fat: 37.77 ± 6.38%; 6.66 ± 1.01 s up-and-go test) voluntarily participated in this randomized, double-blinded, controlled trial. Participants were allocated into four groups (RT+SW, RT+PLA, CON+SW, and CON+PLA). The RT intervention (twice weekly) consisted of different exercises for the whole body performed at submaximal intensities with elastic bands. Both control groups were not involved in any exercise program. A two-way mixed analysis of variance of repeated measures revealed significant improvements in almost all the variables in both intervention groups (p < 0.05). However, significant differences with controls were encountered in isokinetic strength, body fat percentage, and bodily pain. Although the group with SW supplementation obtained greater effect sizes, non-significant differences between both RT groups were observed. In conclusion, the determinant factor of the adaptations seems to be RT rather than SW.

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“…In a study by Zanforlini et al, treating COPD patients with oral magnesium had shown an anti-inflammatory role. Still, it does not substantially improve lung function, physical activity, and quality of life in COPD patients [ 33 ]. A recent systematic review and meta-analysis study by Jahangir et al has studied that intravenous magnesium was associated with favorable deviation of FEV1 and peak expiratory flow rate (PEFR).…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Serum Magnesium Level and Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Makwana¹,

Patel²,

Sonagara³

2022

Cureus

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IntroductionAlthough chronic obstructive pulmonary disease (COPD) is preventable and treatable, it is a major public health problem. The mortality risks are higher in patients with exacerbations. Magnesium (Mg) is crucial in numerous physiological processes, including membrane stabilization. However, incomplete information is available regarding the effect of magnesium on the frequency of acute exacerbation of COPD. ObjectivesTo determine the serum magnesium level in COPD patients and its correlation with acute exacerbation of COPD. Materials and methodsThis cross-sectional study included 100 patients diagnosed with acute exacerbation of COPD. The serum magnesium level was measured in all patients with acute exacerbation of COPD at admission. Serum Mg level <1.7 mg/dl was considered hypomagnesemia. The correlation between serum magnesium level and duration of hospital stay and patient outcome was studied. ResultsIn the present study, hypomagnesemia was reported in 57% of patients with acute exacerbation of COPD. The duration of hospital stay (more than seven days) among hypomagnesemia (80.7%) patients was significantly higher than that of the normomagnesemia patients (55.8%). Mortality in patients with hypomagnesemia was higher than in patients with normomagnesemia, although not statistically significant. ConclusionHypomagnesaemia is a common finding in acute exacerbation of COPD. The level of magnesium found is related to the length of hospital stay, but it is not related to mortality among patients with acute exacerbation of COPD. Further studies with larger sample sizes and extended follow-up periods are required to validate the results.

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Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients

Cited by 21 publications

References 31 publications

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Effects of Microfiltered Seawater Intake and Variable Resistance Training on Strength, Bone Health, Body Composition, and Quality of Life in Older Women: A 32-Week Randomized, Double-Blinded, Placebo-Controlled Trial

Correlation Between Serum Magnesium Level and Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease (COPD)

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