Clinical Trials and Novel/Emerging Treatment

Mizrahi, Jonathan; Abdel-Wahab, Reham; Javle, Milind

doi:10.1007/978-3-030-22258-1_13

Cited by 1 publication

(1 citation statement)

References 138 publications

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“…3 Nevertheless, some researchers have recently reported on ICC patients unfit for surgery who were treated with percutaneous thermal ablation, initially radiofrequency and later microwaves. [4][5][6][7][8][9][10] According to the literature, survival of patients with small (<3 cm) tumors was better than that of patients with larger tumors. In 2017, Shindoh 11 reviewed published studies on ablative therapies of ICC, which at that time were limited in number and with small numbers of treated patients.…”

Section: Introductionmentioning

confidence: 99%

Intrahepatic Cholangiocarcinoma and Thermal Ablation: Long-term Results of An Italian Retrospective Multicenter Study

Giorgio¹,

Gatti²,

Montesarchio³

et al. 2019

Journal of Clinical and Translational Hepatology

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Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma (ICC), percutaneous thermal ablation can be an alternative treatment for patients unfit for surgery. Our aim was to compare long-term results of percutaneous sonographically-guided radiofrequency ablation (RFA) with highpowered microwave ablation (MWSA) in treatment of ICC. Methods: Results of 71 ICC patients with 98 nodules treated with RFA (36 patients) or MWSA (35 patients) between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively reviewed. Cumulative overall survival curves were calculated with the Kaplan-Meyer method and differences with the log-rank test. Eleven possible factors affecting survival were analyzed. Results: Overall survival of the entire series was 88%, 65%, 45% and 34% at 12, 36, 60 and 80 months, respectively. Patients treated with MWSA survived longer than patients treated with RFA (p < 0.005). The MWSA group with ICC nodules #3 cm or nodules up to 4 cm survived longer than the RFA group (p < 0.0005). In patients with nodules >4 cm, no significant difference was found. Disease-free survival and progression-free survival were better in the MWSA group compared to the RFA group (p < 0.005). Diameter of nodules and MWSA were independent factors predicting a better survival. No major complications were observed. Conclusions: MWSA is superior to RFA in treating ICC unfit for surgery, achieving better long-term survival in small (#3 cm) ICC nodules as well as nodules up to 4 cm of neoplastic tumors and should replace RFA. Citation of this article: GiorgioA, Gatti P, Montesarchio L, Santoro B, Dell'Olio A, Crucinio N, et al. Intrahepatic cholangiocarcinoma and thermal ablation: long-term results of an Italian retrospective multicenter study.

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