Clinical trials in cancer

Green, J A

doi:10.1038/bjc.2011.137

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…As one major way of combating cancer cells is by killing them, one of the approaches to restrain tumor growth is by activating the apoptotic machinery in the tumor cells [21] . The changes in cellular morphology (e.g., membrane distortion, blebbing), condensation and fragmentation of DNA are two significant characteristic features of apoptosis [22] . Nucleosomal fragmentation was evident through microscopic study of cellular morphology and DAPI staining of the cells.…”

Section: Discussionmentioning

confidence: 99%

Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase–mediated signaling via reactive oxygen species elevation

Ghosh

Bishayee

Paul

et al. 2013

Journal of Integrative Medicine

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Section: Discussionmentioning

confidence: 99%

Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase–mediated signaling via reactive oxygen species elevation

Ghosh

Bishayee

Paul

et al. 2013

Journal of Integrative Medicine

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“…Chemotherapy to treat cancer was introduced more than 50 years ago, and has generally shown considerable efficiency for the treatment of testicular cancer and certain leukaemias, but in general its success rate against breast, colon, lung and cervical cancers has been less than spectacular. Ideally, chemotherapeutic drugs should specifically target neoplastic cells only and should reduce tumour burden by inducing cytotoxic and/or cytostatic effects, with minimal collateral damage to neighbouring normal cells .…”

Section: Introductionmentioning

confidence: 99%

Quercetin induces cytochrome‐c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug‐DNA interaction

et al. 2013

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“…The initiation of cellular morphology change and DNA fragmentation are two major hallmarks of cancer (Green, 2011). The apoptotic cells' chromosome gets condensed and fragmented.…”

Section: Discussionmentioning

confidence: 99%

“…When a drug induces DNA fragmentation, it can have a potent anti-cancer role as well. The changes in cellular morphology (membrane distortion, blebbing) also are the major hallmark of apoptosis (Green, 2011). So, the drug which can induce DNA fragmentation, and cell blebbing, could be considered one with an anti-cancer potential and that can be used to combat cancer.…”

Section: Introductionmentioning

confidence: 99%

Homeopathic mother tincture of Conium initiates reactive oxygen species mediated DNA damage and makes HeLa cells prone to apoptosis

Bishayee¹,

Mukherjee²,

Paul³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Adverse side-effects and lack of scientific validation of some chemotherapeutic agents prevent the use of many traditional medicines claimed to have anti-cancer effects. Ethanolic extract of Conium maculatum has long been used in traditional and alternative systems of medicine including homeopathy for the treatment of glandular enlargements, cancerous tumours or hard lumps of testicles, prostate, ovaries, breasts and/ or uterus, particularly in the breast. However, if and how it acts still remains scientifically unknown. This study aims to test if Conium extract (CE), used as mother tincture of Conium in homeopathy, has demonstrable anti-cancer potentials without having much cytotoxicity in normal cells. Cytotoxicity of the drug was tested by conducting MTT assay on both normal (peripheral blood mononuclear cells) and HeLa cells. We also evaluated DNA fragmentation and DNA damage by DAPI and diphenylamine assay. The LDH activity assay was done to evaluate the percentages of apoptosis and necrosis. ROS accumulation also was evaluated to pin-point the actual events of apoptosis. Administration of drug clearly demonstrated its anti-cancer potentials as evidenced by the DNA damage analysis. The ROS activity also increased in case of the CE treated cells. LDH data revealed that the mode of cell death was mainly apoptotic and not necrotic. CE appears to induce apoptosis of cancer cells through ROS mediated pathway, and has negligible cytotoxicity against normal cells.

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Clinical trials in cancer

Cited by 10 publications

References 3 publications

Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase–mediated signaling via reactive oxygen species elevation

Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase–mediated signaling via reactive oxygen species elevation

Quercetin induces cytochrome‐c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug‐DNA interaction

Homeopathic mother tincture of Conium initiates reactive oxygen species mediated DNA damage and makes HeLa cells prone to apoptosis

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