Clinical trials of resveratrol efficacy and safety

Ćućuz, Veljko; Cvejić, Jelena; Gojkovic-Bukarica, Ljiljana

doi:10.2298/vsp201126006c

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Results from several clinical trials indicate that resveratrol may have cardioprotective effects, increasing antioxidant capacity, having a positive impact on circulatory function and anti-diabetic effects in humans [ 237 ]. Some of those reports have examined kidney function, but no significant results have been found [ 238 , 239 , 240 ].…”

Section: Sirtuins and Renal Oxidative Stressmentioning

confidence: 99%

Sirtuins and Renal Oxidative Stress

2021

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Renal failure is a major health problem that is increasing worldwide. To improve clinical outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk factor for the development and progression of kidney disease. Cells develop an imbalance of oxidants and antioxidants as they age, resulting in oxidative stress and the development of kidney damage. Calorie restriction (CR) is recognized as a dietary approach that promotes longevity, reduces oxidative stress, and delays the onset of age-related diseases. Sirtuins, a type of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, are considered to be anti-aging molecules, and CR induces their expression. The sirtuin family consists of seven enzymes (Sirt1–7) that are involved in processes and functions related to antioxidant and oxidative stress, such as DNA damage repair and metabolism through histone and protein deacetylation. In fact, a role for sirtuins in the regulation of antioxidants and redox substances has been suggested. Therefore, the activation of sirtuins in the kidney may represent a novel therapeutic strategy to enhancing resistance to many causative factors in kidney disease through the reduction of oxidative stress. In this review, we discuss the relationship between sirtuins and oxidative stress in renal disease.

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Section: Sirtuins and Renal Oxidative Stressmentioning

confidence: 99%

Sirtuins and Renal Oxidative Stress

2021

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“…A variety of techniques have been used to enhance the pharmacokinetic properties and then positive benefits of RSV. [29][30][31] Co-administration with bioenhancer is one such approach to improve oral bioavailability. Several herbal substances, such as PIP, quercetin, naringin, curcumin, and glycyrrhizin, have been shown to enhance the drug's pharmacokinetic parameters.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol

Salian,

Noushida,

Jaswanth Gowda

et al. 2023

Int J. Pharm. Investigation

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Background: Resveratrol (3,4,5-trihydroxystilbene), a polyphenol derived from plant sources, despite its cardioprotective properties, has limited therapeutic impact due to its low in vivo bioavailability and rapid metabolism, which are major barriers to its effectiveness. Piperine, a nitrogenous substance, has well-established bioenhancer activity and cardioprotective potential. The objective of the study was to investigate the cardioprotective potential of resveratrol and piperine on isoproterenol-induced myocardial infarction in rats, both alone and in combination and to assess the oral bioavailability of resveratrol when co-administered with piperine. Materials and Methods: Resveratrol, piperine, and their combinations (20 mg/kg, oral) were administered to rats as pre-treatments for 28 days. Myocardial infarction was induced by giving isoproterenol (85 mg/kg) subcutaneously. Pharmacokinetic parameters were analyzed by UFLC using rat plasma. The chromatographic separation was achieved on Eclipse plus C 18 Column (25 cm x 5 cm x 4.6µ) with L1 packing using mobile phase containing mixer of milli Q water and methanol (30:70% v/v) at a flow rate of 1 mL/min. Results: The treatment group exhibited a considerable (p<0.001) improvement in heart rate, biomarker, antioxidant, and histological changes compared to the isoproterenol group, confirming the effectiveness of resveratrol. A significant improvement in pharmacokinetic parameters of resveratrol was observed in plasma samples of animals treated with a combination, as compared to those treated with resveratrol alone. Conclusion: The combination of resveratrol and piperine significantly reduced the risk of myocardial infarction induced by isoproterenol when compared to the group that received resveratrol alone. This effect can be attributed to the cardioprotective potential of resveratrol and piperine, as well as piperine's ability to enhance the oral bioavailability of resveratrol.

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