Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management

Smith, Amanda; Miles, Victoria N.; D, Holmes; Chen, Xin; W, Lei

doi:10.3390/medicines8100058

Cited by 12 publications

(11 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…KiOil ® is a patented combination of arnica, devil’s claw, green tea, and liposomes created by Medifarmagen SRL a Spin-off of Catanzaro’s University. These substances showed anti-inflammatory and analgesic properties, as described before [ 28 , 30 , 31 , 32 , 34 ].…”

Section: Methodsmentioning

confidence: 56%

“…It may reduce nitric oxide (NO) and Tumor Necrosis Factor α (TNF α) synthesis in macrophages and increase the production of antinflammatory cytokine interleukin-10 (IL-10). Anti-oedemic action was also documented [ 28 ]. Widrig et al documented in 204 patients with hand osteoarthritis that topical arnica had a comparable effect to topical ibuprofen in relieving symptoms [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…The active components in arnica may reduce nitric oxide (NO) and TNF α synthesis in macrophages and increase the production of anti-inflammatory cytokine interleukin-10 (IL-10). Anti-oedemic action was also documented [ 28 ]. Menghini et al reported that devil’s claw ( Harpagophytum procumbens) was more effective than placebo in reducing lower back pain and inflammation [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

et al. 2022

View full text Add to dashboard Cite

High-intensity, low-frequency magnetic fields (MFs) have been widely used in the treatment of diseases and in drug delivery, even though they could induce structural changes in pharmacological molecules. Morphological changes in ketoprofen and KiOil were investigated through Fourier-transform infrared spectroscopy (FT-IR). Unsupervised principal component analysis was carried out for data clustering. Clinical validation on 22 patients with lower back pain was managed using diamagnetic therapy plus topical ketoprofen or KiOil. The Numerical Rating Scale (NRS) and Short-Form Health Survey 36 (SF-36) were used to evaluate clinical and functional response. Ketoprofen showed clear clustering among samples exposed to MF (4000–650 cm−1), and in the narrow frequency band (1675–1475 cm−1), results evidenced structural changes which involved other excipients than ketoprofen. KiOil has evidenced structural modifications in the subcomponents of the formulation. Clinical treatment with ketoprofen showed an average NRS of 7.77 ± 2.25 before and an average NRS of 2.45 ± 2.38 after MF treatment. There was a statistically significant reduction in NRS (p = 0.003) and in SF-36 (p < 0.005). Patients treated with KiOil showed an average NRS of 7.59 ± 2.49 before treatment and an average NRS of 1.90 ± 2.26 after treatment (p < 0.005). SF-36 showed statistical significance for all items except limitations due to emotional problems. A high-intensity pulsed magnetic field is an adjunct to topical treatment in patients with localized pain, and the effect of MF does not evidence significant effects on the molecules.

show abstract

Section: Methodsmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In einzelnen Studien war die lokale Arnikazubereitung so wirksam wir Ibuprofen oder Diclofenac. Wirksamkeitsmitbestimmend ist der Entzündungshemmer Helenalin [18].…”

Section: Topische Anwendung Von Pflanzenzubereitungenunclassified

Naturheilkundliche Therapien bei Mikro- und Makrotraumen durch Sport

Vlachojannis¹,

Chrubasik‐Hausmann²

2022

Erfahrungsheilkunde

View full text Add to dashboard Cite

ZusammenfassungMikro- und Makrotraumen durch Sport gehen mit Muskelschädigung, Entzündungsreaktionen und oxidativem Stress einher. Diverse Metaanalysen evaluieren das Nutzen-Risiko-Profil von naturheilkundlichen Therapien zur verletzungsvorbeugenden Wirkung bzw. zur Beschleunigung der Regenerationsprozesse: Um Muskelkater und Müdigkeit vorzubeugen, waren Massagen wirksamer als Kompressionsverbände. Heiss-/Kaltwassertherapie inklusive Fango und Cryotherapie. Elektrostimulation, Dehnübungen und gezielte Gymnastik waren wenig wirksam.Massage und Kälteanwendungen hemmten die Entzündungsreaktionen mehr als die anderen Maßnahmen. Studien mit Laser- und Vibrationstherapie waren in der Metaanalyse nicht berücksichtigt und auch nicht die Studien zur Akupunkturbehandlung. Zu keiner der bei Mikro- und Makrotraumen durch Sport eingesetzten Therapien ist die Wirksamkeit überzeugend belegt. Konfirmatorische Studien sind dringend notwendig, damit die Methoden als Zusatz zur bedarfsangepassten, ausgewogenen Ernährung in der Sportmedizin empfohlen werden können.

show abstract

“…It has a higher rate in anterior teeth 85% than in molars that have 45% plaque reduction and periodontal pockets reduction [4] . The purpose of root planning is to remove infected cementum, in addition to endotoxins on the root surface, the need for smoothing is still emphasized by the considerable reduction of microorganisms as well as calculus [5] . In non-surgical periodontal treatment antiseptic agents such as chlorhexidine are used, however, it has been observed to have cytotoxicity and prevent fibroblast proliferation, causing adverse effects at the time of use [6] .…”

Section: Introductionmentioning

confidence: 99%

Use of alternative antiseptics in dentistry: Literature review

Ávila,

Enríquez,

Cantú

et al. 2023

Int. J. Appl. Dent. Sci.

View full text Add to dashboard Cite

Antiseptic agents are used as an adjunctive tool in periodontal therapy, to prevent infection, better plaque removal, as well as preoperative cleaning of the surgical site, and postoperative use. Chlorhexidine is considered a good antiseptic agent, but it has several important adverse health effects if not used correctly by the patient. The objectives of this review are: a) To understand the different antiseptics that exist, b) To determine the adverse effects of chlorhexidine, c) To compare the effects of antiseptics in different studies.

show abstract

Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management

Cited by 12 publications

References 56 publications

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

FT-IR Analysis of Structural Changes in Ketoprofen Lysine Salt and KiOil Caused by a Pulsed Magnetic Field

Naturheilkundliche Therapien bei Mikro- und Makrotraumen durch Sport

Use of alternative antiseptics in dentistry: Literature review

Contact Info

Product

Resources

About