Clinical Trials Trends of 2023 Year and Visionary to the Future

Abstract

Introduction: The importance of studying historical changes in the development of human activity is substantiated by the need to systematize such changes and the possibility of predicting them. Historical changes are extended in time and do not have clear boundaries, requiring greater involvement in their study and the prerequisites for their appearance. Clinical research is more than just the practical application of medical changes and discoveries. They make changes in medical practice but are subject to change. Changes in the clinical research industry are tendentious and develop gradually, requiring study and forecasting. According to the generally accepted temporal gradation of the forecast, there is an operational forecast of up to one month, a short-term forecast of up to one year, a medium-term forecast of up to five years, a long-term forecast of up to 20 years and a long-term forecast over long-term, and a short-term forecast is common in the clinical research industry. We analyzed publications in open sources from 1930 to 2023 by keywords in the Russian-language literature trends in the clinical trial industry and the English-language literature trends in the clinical trial industry. Discussion and Conclusion: Trends in the development of clinical trials until the end of 2023 can be divided into two groups, those related to changes in the conduct of clinical trials and changes in the products of clinical trials in nosologies. If in the first group, the trends remain similar to 2022, the ongoing digitalization of operations, the shift of centralized research towards decentralization, and the shift in protocol design towards patient-centricity, then in the second group, the number of expected drugs has decreased, and there is a shift of drugs towards biologics and gene therapy drugs.