Clinical trials with cephacetrile in the treatment of secondary respiratory infections in childhood pertussis

Treatment of Human Brucellosis with Rifampin plus Minocycline

“…The last issue regards the use of tetracycline in children under 8 years of age, but doxycycline is recommended by the American Academy of Pediatrics for the treatment of Rocky Mountain spotted fever at any age 21 . However, no patients complained of teeth discoloration at the end of follow-up, and it is not mentioned in the works of other authors who used minocycline in children 11,22 , suggesting the possibility of using this antibiotic for a short period among pediatric patients.…”

“…Minocycline also chelates calcium less than other tetracyclines and so it is theoretically less likely to cause tooth staining (due to the deposition of tetracycline/orthophosphate complexes) 10 . Half of each dose of rifampin was administered by means of parenteral route in 15 minutes, the other half in 2 hours, in order to achieve higher blood levels for a longer period afterward, approaching the kinetic profiles and improving the theoretical synergistic effect of rifampin and minocycline -each antibiotic acts on protein synthesis with a different mechanism (rifampin inhibits the mRNA synthetase, tetracyclines block the 30S subunit of the ribosome) 11 .…”