2019
DOI: 10.1038/s41419-019-1769-9
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Clinical update on head and neck cancer: molecular biology and ongoing challenges

Abstract: Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies, surgery and radiotherapy represent the primary treatment options for most patients. But these treatments are associated with significant morbidity and a reduction in quality of life. Resistance to both radiotherapy and the only available targeted therapy, and subsequent relapse are common. Research has therefore focussed on identifying bi… Show more

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Cited by 403 publications
(452 citation statements)
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References 216 publications
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“…As expected, outcomes and survival curves differ according to stage (Supplementary Figure 2). Tumor volume data as determined by delineation on RT planning CT images were available for 166 patients with a median volume of 23.2 cm 3 . Not all patients finished chemotherapy, but 126 patients (63%) received a cumulative dose of and above 200 mg/m 2 body surface area.…”
Section: Role Of Clinical Factors and Patient Characteristics In Chemmentioning
confidence: 99%
See 1 more Smart Citation
“…As expected, outcomes and survival curves differ according to stage (Supplementary Figure 2). Tumor volume data as determined by delineation on RT planning CT images were available for 166 patients with a median volume of 23.2 cm 3 . Not all patients finished chemotherapy, but 126 patients (63%) received a cumulative dose of and above 200 mg/m 2 body surface area.…”
Section: Role Of Clinical Factors and Patient Characteristics In Chemmentioning
confidence: 99%
“…Cure and locoregional failure rates of around 50 and 25%, respectively, facilitate the evaluation of biological determinants of radiation response. Using biological characteristics of the tumors, outcome association studies revealed many potential determinants of prognosis and treatment response in HNSCC (3)(4)(5)(6)(7). This study evaluates complementarity and hierarchy of radiation response determining "HNSCC biology.…”
Section: Introductionmentioning
confidence: 99%
“…The heterogeneous nature of HNSCC calls for various treatment approaches [35]. Recent developments towards understanding the HNSCC disease have led to identify various targets and to develop the corresponding targeted therapies [36]. EGFR-targeted therapies, such as antisense gene therapy, monoclonal antibodies, and tyrosine kinase inhibitors, were first approved for HNSCC treatment [11,14].…”
Section: Discussionmentioning
confidence: 99%
“…As a strong correlation between PGRMC1 expression and tumor progression has been confirmed, it has become a novel and promising target of the therapeutic intervention for cancer treatments. Head and neck squamous cell carcinoma (HNSC) is one of the most common types of human cancer, with an annual incidence of more than 500,000 cases worldwide (Leemans et al, 2018;Alsahafi et al, 2019). Despite surgery, radiation, and chemotherapy, approximately half of all patients will die of the disease (Bratman et al, 2016).…”
Section: Introductionmentioning
confidence: 99%