ObjectivesLow‐profile cystostomy tubes provide an alternative to conventional cystostomy tubes with external tubing. Previously, these have been placed surgically involving coeliotomy, cystotomy and cystopexy, or have been used as replacement tubes in existing stoma sites. The purpose of this study is to describe a technique for, and the outcomes of, single‐step, non‐surgical low‐profile cystostomy tube placement.Materials and MethodsAll cases that had single‐step, non‐surgical placement of low‐profile cystotomy tube attempted at the authors' institutions were included in this study. Data, including success rates, outcomes and complications, were extracted from the medical records.ResultsTen client‐owned dogs were inclided. Single‐step, non‐surgical placement was successful in eight out of 10 dogs, with placement being unsuccessful in two thus necessitating coeliotomy. The median duration that low‐profile cystostomy tubes were in place was 7.0 months (range 4 days to 38 months). Seven of the eight dogs required replacement of their cystostomy tube. Mean time until first tube replacement was 103 days (range 13 to 363 days).Clinical SignificanceSingle‐step, non‐surgical placement of a low‐profile cystostomy tube is a viable alternative to surgical placement. Lack of cystopexy does not appear to result in complications. Conversion to coeliotomy might be required if tube placement is not successful with this technique. Complications seen with non‐surgical tube placement such as inadvertent tube removal were similar to those previously reported for surgically placed tubes.