Clinical use of 10% soybean oil emulsion

McNiff, Barbara Lenard

doi:10.1093/ajhp/34.10.1080

Cited by 7 publications

(3 citation statements)

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“…In 1972, FDA approved the first intravenous fat emulsion, Intralipid®, which was composed of egg phospholipids, soy bean oil, and glycerin. Intralipid® is used to deliver essential fatty acids through intravenous injection for the patients who are unable to absorb those nutrients through diet[27]. The success of clinical application of this emulsion has paved the road for encapsulating and dissolving hydrophobic compounds into the internal oil core of emulsions for treating other diseases and disorders[28].…”

Section: Biocompatible and Biodegradable Nanoparticlesmentioning

confidence: 99%

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Wang

Nie

et al. 2014

The Journal of Nutritional Biochemistry

427

245

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Nanotechnology is an innovative approach that has potential applications in nutraceutical research. Phytochemicals have promising potential for maintaining and promoting health, as well as preventing and potentially treating some diseases. However, the generally low solubility, stability, bioavailability and target specificity, together with the side-effects seen when used at high levels, have limited their application. Indeed, nanoparticles can increase solubility and stability of phytochemicals, enhance their absorption, protect them from premature degradation in the body, and prolong their circulation time. Moreover, these nanoparticles exhibit high differential uptake efficiency in the target cells (or tissue) over normal cells (or tissue)through preventing them from prematurely interacting with the biological environment, enhanced permeation and retention effect in disease tissues, and improving their cellular uptake, resulting in decreased toxicity, In this review we outline the commonly used biocompatible and biodegradable nanoparticles including liposomes, emulsions, solid lipid nanoparticles, nanostructured lipid carriers, micelles and poly (lactic-co-glycolic acid) (PLGA) nanoparticles. We then summarize studies that have used these nanoparticles as carriers for EGCG, quercetin, resveratrol and curcuminadministration to enhance their aqueous solubility, stability, bioavailability, target specificity, and bioactivities.

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Section: Biocompatible and Biodegradable Nanoparticlesmentioning

confidence: 99%

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Wang

Nie

et al. 2014

The Journal of Nutritional Biochemistry

427

245

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“…This research project did not include hearts from hibernating AGS or other hibernating mammals which may have added further important findings to this study. Instead of studying the specific effects of individual lipids, we used Intralipid™, a water soluble fat emulsion approved for human use as a part of total parenteral nutrition (McNiff 1977), made of soy bean oil, egg phospholipids and glycerin and consisting of a multitude of different lipids (Morris et al 1998). The fact that only functional parameters were found to be improved in AGS with and without Intralipid™, but not infarct size, points more towards improved stunning rather than reduced infarction following myocardial IR.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we used Langendorff-perfused isolated hearts from summer-active AGS and BN rats to test the hypotheses that a) non-hibernating AGS are better protected against normothermic myocardial IR injury than the best-protected rat strain, the BN rat (Baker et al 2000); and b) that administration of lipids through perfusion with Intralipid™, a Food and Drug Administration-approved lipid emulsion routinely used for total parenteral nutrition (McNiff 1977), differentially improves resistance against IR injury in AGS more than in BN rat hearts.…”

Section: Introductionmentioning

confidence: 99%

Lipid emulsion enhances cardiac performance after ischemia–reperfusion in isolated hearts from summer-active arctic ground squirrels

et al. 2017

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Hibernating mammals, like the arctic ground squirrel (AGS), exhibit robust resistance to myocardial ischemia/reperfusion (IR) injury. Regulated preference for lipid over glucose to fuel metabolism may play an important role. We tested whether providing lipid in an emulsion protects hearts from summer-active AGS better than hearts from Brown Norway (BN) rats against normothermic IR injury. Langendorff-prepared AGS and BN rat hearts were perfused with Krebs solution containing 7.5 mM glucose with or without 1% Intralipid™. After stabilization and cardioplegia, hearts underwent 45 minutes global ischemia and 60 minutes reperfusion. Coronary flow, isovolumetric left ventricular pressure and mitochondrial redox state were measured continuously; infarct size was measured at the end of the experiment. Glucose-only AGS hearts functioned significantly better on reperfusion than BN rat hearts. Intralipid™ administration resulted in additional functional improvement in AGS compared to glucose only and BN rat hearts. Infarct size was not different among groups. Even under non-hibernating conditions, AGS hearts performed better after IR than the best-protected rat strain. This, however, appears to strongly depend on metabolic fuel: Intralipid™ led to a significant improvement in return of function in AGS, but not in BN rat hearts, suggesting that year-round endogenous mechanisms are involved in myocardial lipid utilization that contributes to improved cardiac performance, independent of the metabolic rate decrease during hibernation. Comparative lipid analysis revealed four candidates as possible cardioprotective lipid groups. The improved function in Intralipid™-perfused AGS hearts also challenges the current paradigm that increased glucose and decreased lipid metabolism are favorable during myocardial IR.

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Nanocarrier-Based Antimicrobial Phytochemicals

Fahimirad

Hatami

2019

Advances in Phytonanotechnology

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Clinical use of 10% soybean oil emulsion

Cited by 7 publications

References 0 publications

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Lipid emulsion enhances cardiac performance after ischemia–reperfusion in isolated hearts from summer-active arctic ground squirrels

Nanocarrier-Based Antimicrobial Phytochemicals

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