Clinical Use of Carotid Intima-Media Thickness: Review of the Literature

Hurst, R. Todd; Ng, Daniel W.C.; Kendall, Christopher; Khandheria, Bijoy K.

doi:10.1016/j.echo.2007.02.028

Cited by 103 publications

(67 citation statements)

References 69 publications

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“…It is a simple, reliable, and non-invasive method, widely used in clinical trials for detecting asymptomatic atherosclerosis. 21 The presence of plaques and increased intima-media thickness in the carotid arteries is a strong predictor for cardiovascular events in general population. 22 CA-IMT is increased in patients with renal failure and may help in predicting patients that are at a higher risk for future cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Mutluay¹,

Konca²,

Erten³

et al. 2010

Renal Failure

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Objective: Uremia is associated with accelerated atherosclerosis and increased cardiovascular mortality in patients with end-stage renal disease (ESRD). Cardiac injury markers, such as myoglobin, creatine kinase-MB (CK-MB), or troponins, frequently used to recognize acute coronary events, may be falsely elevated in this patient group. In this study, our aim was to (i) test serum levels of myoglobin, CK-MB, and troponin I (cTnI) in ESRD patients without coronary artery disease (CAD) and compare the results with healthy controls and (ii) to investigate the association between these markers and carotid artery intima-media thickness (CA-IMT), high-sensitive C-reactive protein (hs-CRP), and serum uric acid (SUA) levels in ESRD patients. Materials and methods: Fifty-two ESRD patients (25 hemodialysis and 27 peritoneal dialysis) and 17 healthy controls were included in the study. Serum levels of myoglobin, CK-MB, and cTnI were measured and ultrasonographic CA-IMT was determined in all participants. SUA and hs-CRP levels were only measured in the ESRD group. Results: Serum myoglobin, CK-MB levels, and the mean CA-IMT were significantly higher in ESRD group (p < 0.01), whereas cTnI levels were not different compared to healthy controls (p = 0.70). There was also a positive correlation between CA-IMT and cTnI levels (p = 0.003, r = 0.35) and CA-IMT and hs-CRP (p = 0.03, r = 0.30) or SUA levels (p = 0.003, r = 0.43). Conclusion: cTnI may serve as a more sensitive marker in detecting cardiovascular events in patients with renal failure. Besides the traditional risk factors of atherosclerosis, cTnI, hs-CRP, and SUA may have a predictive role in recognizing premature atherosclerosis in ESRD patients.

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Section: Introductionmentioning

confidence: 99%

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Mutluay¹,

Konca²,

Erten³

et al. 2010

Renal Failure

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“…While the study did determine CV risk by routinely used CV risk score calculators, it used subclinical atherosclerosis defined by CIMT > 0.9 mm and/or presence of frank carotid plaques. Although CIMT is a reliable marker of atherosclerosis 17 that may predict future CV events 18 , the investigators had no data that directly addressed CV events in their participants. Further, there is limited data on how CIMT precisely correlates with risk of CV events.…”

Section: Rheumatologymentioning

confidence: 99%

Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis: How Far Are We from the Truth?

Belur

Mehta

2018

J Rheumatol

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“…16 B-mode sonography of the carotid intima-media thickness has also recently become a noted characteristic for assessment of cardiovascular risk. 44,45 Stateof-the-art 3D sonographic systems can now also provide measurement of the total plaque volume and area [46][47][48] and lumen wall volume 41 ; preliminary (ex vivo) research has validated the ability of sonography to identify different carotid plaque components. 50 Rundek et al 51 have recently reported an association between the maximum carotid plaque thickness and the risk of cerebrovascular events.…”

Section: Sonographymentioning

confidence: 99%

Vascular Wall Imaging of Vulnerable Atherosclerotic Carotid Plaques: Current State of the Art and Potential Future of Endovascular Optical Coherence Tomography

Standish

Spears

Marotta

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY:As stroke is one of the leading causes of death and long-term morbidity worldwide, the research community has studied cardiac embolic sources, as well as vessel wall pathologies. For the latter, attention has been focused on defining morphologic tissue features associated with catastrophic events stemming from the carotid artery. Multiple noninvasive imaging modalities are currently being used to image and classify carotid atherosclerotic plaques, such as MR imaging, CT, and sonography, in an effort to provide clinically relevant predictive metrics for use in patient risk stratification and to define appropriate treatment options. This article compares and contrasts these existing clinical imaging modalities along with discussion of a new endovascular technique originally developed for cardiology, OCT, with which 3D comprehensive high-resolution images of the arterial wall can be acquired.ABBREVIATIONS: AHA ϭ American Heart Association; CE ϭ contrast-enhanced; CI ϭ confidence interval; HR ϭ hazard ratio; MDCTA ϭ multidetector row CT angiography; MRDTI ϭ MR direct thrombus imaging; OCT ϭ optical coherence tomography; TOF ϭ time-of-flight

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Clinical Use of Carotid Intima-Media Thickness: Review of the Literature

Cited by 103 publications

References 69 publications

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis: How Far Are We from the Truth?

Vascular Wall Imaging of Vulnerable Atherosclerotic Carotid Plaques: Current State of the Art and Potential Future of Endovascular Optical Coherence Tomography

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