Clinical use of fresh-frozen plasma in neonatal intensive care unit

Altuntaş, Nilgün; Yenicesu, İdil; Beken, Serdar; Kulalı, Ferit; Belen, Fatma Burcu; Hırfanoğlu, İbrahim Murat; Önal, Esra; Türkyılmaz, Canan; Ergenekon, Ebru; Koç, Esin; Atalay, Yıldız

doi:10.1016/j.transci.2012.05.007

Cited by 15 publications

(19 citation statements)

References 19 publications

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“…In addition, both reported a significant proportion of use noncompliant with published recommendations. Altuntas et al 12 reported a lower rate of 2%; however, the usage outside of guidelines was high.…”

Section: Discussionmentioning

confidence: 95%

Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study

Motta

Vecchio

Perrone

et al. 2014

Arch Dis Child Fetal Neonatal Ed

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Section: Discussionmentioning

confidence: 95%

Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study

Motta

Vecchio

Perrone

et al. 2014

Arch Dis Child Fetal Neonatal Ed

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“…The problems of small sample size is common to all previous reports of coagulation tests in preterm neonates . To lessen this problem, we attempted (Table ) to estimate the relevant reference intervals using data from the present plus previous studies and to propose tentative recommendations for management of preterm neonates. In doing this we endeavored to incorporate the published recommendations from the Poralla and Bartmann group from Germany, and the Venkatesh and Stanworth groups from Great Britan .…”

Section: Discussionmentioning

confidence: 99%

Reference intervals for common coagulation tests of preterm infants (CME)

et al. 2013

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“…Among these 94 patients, the median number of FFP transfusions per neonate was 1 (IQR: 1-7). Coagulation testing was performed in 399 out of 2577 patients (15.5%), with a median number of coagulation tests per neonate of 1 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). As presented in Figure 1, both the percentage of neonates receiving plasma transfusions and the percentage of neonates in which coagulation was determined decreased over the three epochs (p < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the reduction in coagulation testing may partly explain the reduction in FFP administration over the epochs. Several studies likewise reported that abnormal coagulation was the most commonly used indication for FFP in the NICU [4,10,11,29], while some studies reported otherwise [3,30].…”

Section: Discussionmentioning

confidence: 99%

“…Since these guidelines are mainly based on expert opinion and extrapolate findings from studies in adults, international consensus on the use of FFP is lacking, with wide variation in the use of FFP transfusion among Neonatal Intensive Care Units (NICUs). Reports on the proportion of neonates receiving FFP during admission to the NICU vary from 2 to 11% [3,10,11]. Not much is known on the variation of the use of FFP between neonatal centers or per indication, nor on the variation throughout the years.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center Experience

Houben

Heeger

Stanworth

et al. 2020

JCM

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The aim of this study was to evaluate changes in the use of fresh-frozen plasma (FFP) transfusions and the use of clotting tests in preterm neonates in our center over the past two decades. In this retrospective cohort analysis, we included all consecutive neonates with a gestational age at birth between 24 + 0 and 31 + 6 weeks admitted to our neonatal intensive care unit (NICU) between 2004 and 2019. We divided all included neonates into three consecutive time epochs according to date of birth: January 2004 to April 2009, May 2009 to August 2014 and September 2014 to December 2019. The main outcomes were the use of FFP transfusion, coagulation testing and the indications for FFP transfusion. The percentage of preterm neonates receiving FFP transfusion decreased from 5.7% (47/824) to 3.7% (30/901) to 2.0% (17/852) from the first epoch to the last epoch (p < 0.001). Additionally, the rate of neonates undergoing coagulation testing decreased from 24.3% (200/824) to 14.5% (131/901) to 8% (68/852) over the epochs (p < 0.001). Most FFP transfusions were prescribed prophylactically based on prolongation of activated partial thromboplastin time (aPTT) or prothrombin time (PT) (56%). In conclusion, both the use of FFP transfusions and the use of coagulation tests decreased significantly over the years. The majority of the FFP transfusions were administrated prophylactically for abnormal coagulation tests.

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Clinical use of fresh-frozen plasma in neonatal intensive care unit

Cited by 15 publications

References 19 publications

Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study

Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study

Reference intervals for common coagulation tests of preterm infants (CME)

Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center Experience

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